Donghyeon Kim

Jinhyuk Lee, Wonjin Yoon, Sungdong Kim et al.

Biomedical text mining is becoming increasingly important as the number of biomedical documents rapidly grows. With the progress in natural language processing (NLP), extracting valuable information from biomedical literature has gained popularity among researchers, and deep learning has boosted the development of effective biomedical text mining models. However, directly applying the advancements in NLP to biomedical text mining often yields unsatisfactory results due to a word distribution shift from general domain corpora to biomedical corpora. In this article, we investigate how the recently introduced pre-trained language model BERT can be adapted for biomedical corpora. We introduce BioBERT (Bidirectional Encoder Representations from Transformers for Biomedical Text Mining), which is a domain-specific language representation model pre-trained on large-scale biomedical corpora. With almost the same architecture across tasks, BioBERT largely outperforms BERT and previous state-of-the-art models in a variety of biomedical text mining tasks when pre-trained on biomedical corpora. While BERT obtains performance comparable to that of previous state-of-the-art models, BioBERT significantly outperforms them on the following three representative biomedical text mining tasks: biomedical named entity recognition (0.62% F1 score improvement), biomedical relation extraction (2.80% F1 score improvement) and biomedical question answering (12.24% MRR improvement). Our analysis results show that pre-training BERT on biomedical corpora helps it to understand complex biomedical texts. We make the pre-trained weights of BioBERT freely available at https://github.com/naver/biobert-pretrained, and the source code for fine-tuning BioBERT available at https://github.com/dmis-lab/biobert.

Mujeen Sung, Minbyul Jeong, Yonghwa Choi et al.

In biomedical natural language processing, named entity recognition (NER) and named entity normalization (NEN) are key tasks that enable the automatic extraction of biomedical entities (e.g. diseases and drugs) from the ever-growing biomedical literature. In this article, we present BERN2 (Advanced Biomedical Entity Recognition and Normalization), a tool that improves the previous neural network-based NER tool by employing a multi-task NER model and neural network-based NEN models to achieve much faster and more accurate inference. We hope that our tool can help annotate large-scale biomedical texts for various tasks such as biomedical knowledge graph construction.

Minbyul Jeong, Mujeen Sung, Gangwoo Kim et al.

Biomedical question answering (QA) is a challenging task due to the scarcity of data and the requirement of domain expertise. Pre-trained language models have been used to address these issues. Recently, learning relationships between sentence pairs has been proved to improve performance in general QA. In this paper, we focus on applying BioBERT to transfer the knowledge of natural language inference (NLI) to biomedical QA. We observe that BioBERT trained on the NLI dataset obtains better performance on Yes/No (+5.59%), Factoid (+0.53%), List type (+13.58%) questions compared to performance obtained in a previous challenge (BioASQ 7B Phase B). We present a sequential transfer learning method that significantly performed well in the 8th BioASQ Challenge (Phase B). In sequential transfer learning, the order in which tasks are fine-tuned is important. We measure an unanswerable rate of the extractive QA setting when the formats of factoid and list type questions are converted to the format of the Stanford Question Answering Dataset (SQuAD).

Wonjin Yoon, Jinhyuk Lee, Donghyeon Kim et al.

The recent success of question answering systems is largely attributed to pre-trained language models. However, as language models are mostly pre-trained on general domain corpora such as Wikipedia, they often have difficulty in understanding biomedical questions. In this paper, we investigate the performance of BioBERT, a pre-trained biomedical language model, in answering biomedical questions including factoid, list, and yes/no type questions. BioBERT uses almost the same structure across various question types and achieved the best performance in the 7th BioASQ Challenge (Task 7b, Phase B). BioBERT pre-trained on SQuAD or SQuAD 2.0 easily outperformed previous state-of-the-art models. BioBERT obtains the best performance when it uses the appropriate pre-/post-processing strategies for questions, passages, and answers.