Hongbo Liu

Jiansheng Fang, Jingwen Wang, Anwei Li et al.

In the management of lung nodules, we are desirable to predict nodule evolution in terms of its diameter variation on Computed Tomography (CT) scans and then provide a follow-up recommendation according to the predicted result of the growing trend of the nodule. In order to improve the performance of growth trend prediction for lung nodules, it is vital to compare the changes of the same nodule in consecutive CT scans. Motivated by this, we screened out 4,666 subjects with more than two consecutive CT scans from the National Lung Screening Trial (NLST) dataset to organize a temporal dataset called NLSTt. In specific, we first detect and pair regions of interest (ROIs) covering the same nodule based on registered CT scans. After that, we predict the texture category and diameter size of the nodules through models. Last, we annotate the evolution class of each nodule according to its changes in diameter. Based on the built NLSTt dataset, we propose a siamese encoder to simultaneously exploit the discriminative features of 3D ROIs detected from consecutive CT scans. Then we novelly design a spatial-temporal mixer (STM) to leverage the interval changes of the same nodule in sequential 3D ROIs and capture spatial dependencies of nodule regions and the current 3D ROI. According to the clinical diagnosis routine, we employ hierarchical loss to pay more attention to growing nodules. The extensive experiments on our organized dataset demonstrate the advantage of our proposed method. We also conduct experiments on an in-house dataset to evaluate the clinical utility of our method by comparing it against skilled clinicians.

Jiansheng Fang, Anwei Li, Pu-Yun OuYang et al.

Radiation encephalopathy (REP) is the most common complication for nasopharyngeal carcinoma (NPC) radiotherapy. It is highly desirable to assist clinicians in optimizing the NPC radiotherapy regimen to reduce radiotherapy-induced temporal lobe injury (RTLI) according to the probability of REP onset. To the best of our knowledge, it is the first exploration of predicting radiotherapy-induced REP by jointly exploiting image and non-image data in NPC radiotherapy regimen. We cast REP prediction as a survival analysis task and evaluate the predictive accuracy in terms of the concordance index (CI). We design a deep multimodal survival network (MSN) with two feature extractors to learn discriminative features from multimodal data. One feature extractor imposes feature selection on non-image data, and the other learns visual features from images. Because the priorly balanced CI (BCI) loss function directly maximizing the CI is sensitive to uneven sampling per batch. Hence, we propose a novel weighted CI (WCI) loss function to leverage all REP samples effectively by assigning their different weights with a dual average operation. We further introduce a temperature hyper-parameter for our WCI to sharpen the risk difference of sample pairs to help model convergence. We extensively evaluate our WCI on a private dataset to demonstrate its favourability against its counterparts. The experimental results also show multimodal data of NPC radiotherapy can bring more gains for REP risk prediction.

Dian Zheng, Manyuan Zhang, Hongyu Li et al.

Unified multimodal models for image generation and understanding represent a significant step toward AGI and have attracted widespread attention from researchers. The main challenge of this task lies in the difficulty in establishing an optimal training paradigm due to inherent conflicting targets in understanding and generation tasks. To alleviate these conflicts and pursue higher performance, many researchers adopt varying degrees of model decoupling (e.g., Double image encoders, MOE/MOT architecture, or frozen MLLM). However, excessive model decoupling can lead to the loss of interleave generation ability, undermining the original intent of unified models. In this work, we aim to explore how to mitigate task conflicts without resorting to model decoupling. Firstly, we analyze why decoupling alleviates conflicts by studying the cross-modal attention behavior of models. We observe that model decoupling essentially drives models toward task-specific multimodal interaction patterns, as seen in Qwen-VL and HunyuanImage, and that the more thorough the decoupling, the more consistent the behavior becomes. Motivated by this observation, we propose Attention Interaction Alignment (AIA) loss, which explicitly learns Task-Specific multimodal interaction patterns during training. To demonstrate the generalizability of our AIA loss, we apply it to Emu3 and Janus-Pro during SFT and post-training stage respectively. Without bells and whistles, AIA not only refines cross-modal attention patterns, but also boosts both generation and understanding performance.

Hongbo Liu

Contrastive Language-Image Pre-training (CLIP) has attracted a surge of attention for its superior zero-shot performance and excellent transferability to downstream tasks. However, training such large-scale models usually requires substantial computation and storage, which poses barriers for general users with consumer-level computers. Motivated by this observation, in this paper we investigate how to achieve competitive performance on only one Nvidia RTX3090 GPU and with one terabyte for storing dataset. On one hand, we simplify the transformer block structure and combine Weight Inheritance with multi-stage Knowledge Distillation (WIKD), thereby reducing the parameters and improving the inference speed during training along with deployment. On the other hand, confronted with the convergence challenge posed by small dataset, we generate synthetic captions for each sample as data augmentation, and devise a novel Pair Matching (PM) loss to fully exploit the distinguishment among positive and negative image-text pairs. Extensive experiments demonstrate that our model can achieve a new state-of-the-art datascale-parameter-accuracy tradeoff, which could further popularize the CLIP model in the related research community.