Mingyu Li

Meiqi Sun, Mingyu Li, Junxiong Zhu

Generative AI is widely used to create commercial posters. However, rapid advances in generation have outpaced automated quality assessment. Existing models emphasize generic esthetics or low level distortions and lack the functional criteria required for e-commerce design. It is especially challenging for Chinese content, where complex characters often produce subtle but critical textual artifacts that are overlooked by existing methods. To address this, we introduce E-comIQ-ZH, a framework for evaluating Chinese e-commerce posters. We build the first dataset E-comIQ-18k to feature multi dimensional scores and expert calibrated Chain of Thought (CoT) rationales. Using this dataset, we train E-comIQ-M, a specialized evaluation model that aligns with human expert judgment. Our framework enables E-comIQ-Bench, the first automated and scalable benchmark for the generation of Chinese e-commerce posters. Extensive experiments show our E-comIQ-M aligns more closely with expert standards and enables scalable automated assessment of e-commerce posters. All datasets, models, and evaluation tools will be released to support future research in this area.Code will be available at https://github.com/4mm7/E-comIQ-ZH.

Yuan Wang, Mingyu Li, Haibo Chen

Computer-use agents (CUAs) powered by large language models (LLMs) have emerged as a promising approach to automating computer tasks, yet they struggle with graphical user interfaces (GUIs). GUIs, designed for humans, force LLMs to decompose high-level goals into lengthy, error-prone sequences of fine-grained actions, resulting in low success rates and an excessive number of LLM calls. We propose Goal-Oriented Interface (GOI), a novel abstraction that transforms existing GUIs into three declarative primitives: access, state, and observation, which are better suited for LLMs. Our key idea is policy-mechanism separation: LLMs focus on high-level semantic planning (policy) while GOI handles low-level navigation and interaction (mechanism). GOI does not require modifying the application source code or relying on application programming interfaces (APIs). We evaluate GOI with Microsoft Office Suite (Word, PowerPoint, Excel) on Windows. Compared to a leading GUI-based agent baseline, GOI improves task success rates by 67% and reduces interaction steps by 43.5%. Notably, GOI completes over 61% of successful tasks with a single LLM call.

Jigang Fan, Chunhao Zhu, Xiaobing Lan et al.

Neurotensin receptor 1 (NTSR1), a member of the Class A G protein-coupled receptor superfamily, plays an important role in modulating dopaminergic neuronal activity and eliciting opioid-independent analgesia. Recent studies suggest that promoting \{beta}-arrestin-biased signaling in NTSR1 may diminish drugs of abuse, such as psychostimulants, thereby offering a potential avenue for treating human addiction-related disorders. In this study, we utilized a novel computational and experimental approach that combined nudged elastic band-based molecular dynamics simulations, Markov state models, temporal communication network analysis, site-directed mutagenesis, and conformational biosensors, to explore the intricate mechanisms underlying NTSR1 activation and biased signaling. Our study reveals a dynamic stepwise transition mechanism and activated transmission network associated with NTSR1 activation. It also yields valuable insights into the complex interplay between the unique polar network, non-conserved ion locks, and aromatic clusters in NTSR1 signaling. Moreover, we identified a cryptic allosteric site located in the intracellular region of the receptor that exists in an intermediate state within the activation pathway. Collectively, these findings contribute to a more profound understanding of NTSR1 activation and biased signaling at the atomic level, thereby providing a potential strategy for the development of NTSR1 allosteric modulators in the realm of G protein-coupled receptor biology, biophysics, and medicine.