Chen Wang

Yuying Li, Gaoyang Liu, Chen Wang et al.

Retrieval-Augmented Generation (RAG) is a state-of-the-art technique that mitigates issues such as hallucinations and knowledge staleness in Large Language Models (LLMs) by retrieving relevant knowledge from an external database to assist in content generation. Existing research has demonstrated potential privacy risks associated with the LLMs of RAG. However, the privacy risks posed by the integration of an external database, which often contains sensitive data such as medical records or personal identities, have remained largely unexplored. In this paper, we aim to bridge this gap by focusing on membership privacy of RAG's external database, with the aim of determining whether a given sample is part of the RAG's database. Our basic idea is that if a sample is in the external database, it will exhibit a high degree of semantic similarity to the text generated by the RAG system. We present S$^2$MIA, a \underline{M}embership \underline{I}nference \underline{A}ttack that utilizes the \underline{S}emantic \underline{S}imilarity between a given sample and the content generated by the RAG system. With our proposed S$^2$MIA, we demonstrate the potential to breach the membership privacy of the RAG database. Extensive experiment results demonstrate that S$^2$MIA can achieve a strong inference performance compared with five existing MIAs, and is able to escape from the protection of three representative defenses.

David Oniani, Chen Wang, Yiqing Zhao et al.

Cancer is responsible for millions of deaths worldwide every year. Although significant progress has been achieved in cancer medicine, many issues remain to be addressed for improving cancer therapy. Appropriate cancer patient stratification is the prerequisite for selecting appropriate treatment plan, as cancer patients are of known heterogeneous genetic make-ups and phenotypic differences. In this study, built upon deep phenotypic characterizations extractable from Mayo Clinic electronic health records (EHRs) and genetic test reports for a collection of cancer patients, we developed a system leveraging a joint of phenotypic and genetic features for cancer patient subgrouping. The workflow is roughly divided into three parts: feature preprocessing, cancer patient classification, and cancer patient clustering based. In feature preprocessing step, we performed filtering, retaining the most relevant features. In cancer patient classification, we utilized joint categorical features to build a patient-feature matrix and applied nine different machine learning models, Random Forests (RF), Decision Tree (DT), Support Vector Machine (SVM), Naive Bayes (NB), Logistic Regression (LR), Multilayer Perceptron (MLP), Gradient Boosting (GB), Convolutional Neural Network (CNN), and Feedforward Neural Network (FNN), for classification purposes. Finally, in the cancer patient clustering step, we leveraged joint embeddings features and patient-feature associations to build an undirected feature graph and then trained the cancer feature node embeddings.

David Oniani, Chen Wang, Yiqing Zhao et al.

Cancer is responsible for millions of deaths worldwide every year. Although significant progress hasbeen achieved in cancer medicine, many issues remain to be addressed for improving cancer therapy.Appropriate cancer patient stratification is the prerequisite for selecting appropriate treatment plan, ascancer patients are of known heterogeneous genetic make-ups and phenotypic differences. In thisstudy, built upon deep phenotypic characterizations extractable from Mayo Clinic electronic healthrecords (EHRs) and genetic test reports for a collection of cancer patients, we evaluated variousgraph neural networks (GNNs) leveraging a joint of phenotypic and genetic features for cancer typeclassification. Models were applied and fine-tuned on the Mayo Clinic cancer disease dataset. Theassessment was done through the reported accuracy, precision, recall, and F1 values as well as throughF1 scores based on the disease class. Per our evaluation results, GNNs on average outperformed thebaseline models with mean statistics always being higher that those of the baseline models (0.849 vs0.772 for accuracy, 0.858 vs 0.794 for precision, 0.843 vs 0.759 for recall, and 0.843 vs 0.855 for F1score). Among GNNs, ChebNet, GraphSAGE, and TAGCN showed the best performance, while GATshowed the worst. We applied and compared eight GNN models including AGNN, ChebNet, GAT,GCN, GIN, GraphSAGE, SGC, and TAGCN on the Mayo Clinic cancer disease dataset and assessedtheir performance as well as compared them with each other and with more conventional machinelearning models such as decision tree, gradient boosting, multi-layer perceptron, naive bayes, andrandom forest which we used as the baselines.