Haoran Zhang

Liyang Xie, Haoran Zhang, Zhendong Wang et al.

Diffusion- and flow-based generative models have recently demonstrated strong performance in protein backbone generation tasks, offering unprecedented capabilities for de novo protein design. However, while achieving notable performance in generation quality, these models are limited by their generating speed, often requiring hundreds of iterative steps in the reverse-diffusion process. This computational bottleneck limits their practical utility in large-scale protein discovery, where thousands to millions of candidate structures are needed. To address this challenge, we explore the techniques of score distillation, which has shown great success in reducing the number of sampling steps in the vision domain while maintaining high generation quality. However, a straightforward adaptation of these methods results in unacceptably low designability. Through extensive study, we have identified how to appropriately adapt Score identity Distillation (SiD), a state-of-the-art score distillation strategy, to train few-step protein backbone generators which significantly reduce sampling time, while maintaining comparable performance to their pretrained teacher model. In particular, multistep generation combined with inference time noise modulation is key to the success. We demonstrate that our distilled few-step generators achieve more than a 20-fold improvement in sampling speed, while achieving similar levels of designability, diversity, and novelty as the Proteina teacher model. This reduction in inference cost enables large-scale in silico protein design, thereby bringing diffusion-based models closer to real-world protein engineering applications. The PyTorch implementation is available at https://github.com/LY-Xie/SiD_Protein

Haoran Zhang, Zejun Gong, Zekai Li et al.

Federated learning (FL) allows edge devices to collaboratively train models without sharing local data. As FL gains popularity, clients may need to train multiple unrelated FL models, but communication constraints limit their ability to train all models simultaneously. While clients could train FL models sequentially, opportunistically having FL clients concurrently train different models -- termed multi-model federated learning (MMFL) -- can reduce the overall training time. Prior work uses simple client-to-model assignments that do not optimize the contribution of each client to each model over the course of its training. Prior work on single-model FL shows that intelligent client selection can greatly accelerate convergence, but naïve extensions to MMFL can violate heterogeneous resource constraints at both the server and the clients. In this work, we develop a novel convergence analysis of MMFL with arbitrary client sampling methods, theoretically demonstrating the strengths and limitations of previous well-established gradient-based methods. Motivated by this analysis, we propose MMFL-LVR, a loss-based sampling method that minimizes training variance while explicitly respecting communication limits at the server and reducing computational costs at the clients. We extend this to MMFL-StaleVR, which incorporates stale updates for improved efficiency and stability, and MMFL-StaleVRE, a lightweight variant suitable for low-overhead deployment. Experiments show our methods improve average accuracy by up to 19.1% over random sampling, with only a 5.4% gap from the theoretical optimum (full client participation).

Shaopeng Zhai, Qi Zhang, Tianyi Zhang et al.

Robotic real-world reinforcement learning (RL) with vision-language-action (VLA) models is bottlenecked by sparse, handcrafted rewards and inefficient exploration. We introduce VLAC, a general process reward model built upon InternVL and trained on large scale heterogeneous datasets. Given pairwise observations and a language goal, it outputs dense progress delta and done signal, eliminating task-specific reward engineering, and supports one-shot in-context transfer to unseen tasks and environments. VLAC is trained on vision-language datasets to strengthen perception, dialogic and reasoning capabilities, together with robot and human trajectories data that ground action generation and progress estimation, and additionally strengthened to reject irrelevant prompts as well as detect regression or stagnation by constructing large numbers of negative and semantically mismatched samples. With prompt control, a single VLAC model alternately generating reward and action tokens, unifying critic and policy. Deployed inside an asynchronous real-world RL loop, we layer a graded human-in-the-loop protocol (offline demonstration replay, return and explore, human guided explore) that accelerates exploration and stabilizes early learning. Across four distinct real-world manipulation tasks, VLAC lifts success rates from about 30\% to about 90\% within 200 real-world interaction episodes; incorporating human-in-the-loop interventions yields a further 50% improvement in sample efficiency and achieves up to 100% final success.

Emmanuel Azuh Mensah, Anderson Lee, Haoran Zhang et al.

The explosion of IoT sensors in industrial, consumer and remote sensing use cases has come with unprecedented demand for computing infrastructure to transmit and to analyze petabytes of data. Concurrently, the world is slowly shifting its focus towards more sustainable computing. For these reasons, there has been a recent effort to reduce the footprint of related computing infrastructure, especially by deep learning algorithms, for advanced insight generation. The `TinyML' community is actively proposing methods to save communication bandwidth and excessive cloud storage costs while reducing algorithm inference latency and promoting data privacy. Such proposed approaches should ideally process multiple types of data, including time series, audio, satellite images, and video, near the network edge as multiple data streams has been shown to improve the discriminative ability of learning algorithms, especially for generating fine grained results. Incidentally, there has been recent work on data driven conditional computation of subnetworks that has shown real progress in using a single model to share parameters among very different types of inputs such as images and text, reducing the computation requirement of multi-tower multimodal networks. Inspired by such line of work, we explore similar per patch conditional computation for the first time for mobile vision transformers (vision only case), that will eventually be used for single-tower multimodal edge models. We evaluate the model on Cornell Sap Sucker Woods 60, a fine grained bird species discrimination dataset. Our initial experiments uses $4X$ fewer parameters compared to MobileViTV2-1.0 with a $1$% accuracy drop on the iNaturalist '21 birds test data provided as part of the SSW60 dataset.

Haoran Zhang, Mingyuan Zhou, Wesley Tansey

Spatial profiling technologies in biology, such as imaging mass cytometry (IMC) and spatial transcriptomics (ST), generate high-dimensional, multi-channel data with strong spatial alignment and complex inter-channel relationships. Generative modeling of such data requires jointly capturing intra- and inter-channel structure, while also generalizing across arbitrary combinations of observed and missing channels for practical application. Existing diffusion-based models generally assume low-dimensional inputs (e.g., RGB images) and rely on simple conditioning mechanisms that break spatial correspondence and ignore inter-channel dependencies. This work proposes a unified diffusion framework for controllable generation over structured and spatial biological data. Our model contains two key innovations: (1) a hierarchical feature injection mechanism that enables multi-resolution conditioning on spatially aligned channels, and (2) a combination of latent-space and output-space channel-wise attention to capture inter-channel relationships. To support flexible conditioning and generalization to arbitrary subsets of observed channels, we train the model using a random masking strategy, enabling it to reconstruct missing channels from any combination of inputs. We demonstrate state-of-the-art performance across both spatial and non-spatial prediction tasks, including protein imputation in IMC and gene-to-protein prediction in single-cell datasets, and show strong generalization to unseen conditional configurations.

Stefan Hegselmann, Helen Zhou, Elizabeth Healey et al.

A collection of the accepted Findings papers that were presented at the 4th Machine Learning for Health symposium (ML4H 2024), which was held on December 15-16, 2024, in Vancouver, BC, Canada. ML4H 2024 invited high-quality submissions describing innovative research in a variety of health-related disciplines including healthcare, biomedicine, and public health. Works could be submitted to either the archival Proceedings track, or the non-archival Findings track. The Proceedings track targeted mature, cohesive works with technical sophistication and high-impact relevance to health. The Findings track promoted works that would spark new insights, collaborations, and discussions at ML4H. Both tracks were given the opportunity to share their work through the in-person poster session. All the manuscripts submitted to ML4H Symposium underwent a double-blind peer-review process.

Haoran Zhang, Chenkun Yin, Yanxin Zhang et al.

In this paper, two novel practical methods of Reinforcement Learning from Demonstration (RLfD) are developed and applied to automatic berthing control systems for Unmanned Surface Vessel. A new expert data generation method, called Model Predictive Based Expert (MPBE) which combines Model Predictive Control and Deep Deterministic Policy Gradient, is developed to provide high quality supervision data for RLfD algorithms. A straightforward RLfD method, model predictive Deep Deterministic Policy Gradient (MP-DDPG), is firstly introduced by replacing the RL agent with MPBE to directly interact with the environment. Then distribution mismatch problem is analyzed for MP-DDPG, and two techniques that alleviate distribution mismatch are proposed. Furthermore, another novel RLfD algorithm based on the MP-DDPG, called Self-Guided Actor-Critic (SGAC) is present, which can effectively leverage MPBE by continuously querying it to generate high quality expert data online. The distribution mismatch problem leading to unstable learning process is addressed by SGAC in a DAgger manner. In addition, theoretical analysis is given to prove that SGAC algorithm can converge with guaranteed monotonic improvement. Simulation results verify the effectiveness of MP-DDPG and SGAC to accomplish the ship berthing control task, and show advantages of SGAC comparing with other typical reinforcement learning algorithms and MP-DDPG.