John H. Zhang

Xizhe Wang, Ning Zhang, Jia Wang et al.

In Vitro Fertilization (IVF) is the most widely used Assisted Reproductive Technology (ART). IVF usually involves controlled ovarian stimulation, oocyte retrieval, fertilization in the laboratory with subsequent embryo transfer. The first two steps correspond with follicular phase of females and ovulation in their menstrual cycle. Therefore, we refer to it as the treatment cycle in our paper. The treatment cycle is crucial because the stimulation medications in IVF treatment are applied directly on patients. In order to optimize the stimulation effects and lower the side effects of the stimulation medications, prompt treatment adjustments are in need. In addition, the quality and quantity of the retrieved oocytes have a significant effect on the outcome of the following procedures. To improve the IVF success rate, we propose a knowledge-based decision support system that can provide medical advice on the treatment protocol and medication adjustment for each patient visit during IVF treatment cycle. Our system is efficient in data processing and light-weighted which can be easily embedded into electronic medical record systems. Moreover, an oocyte retrieval oriented evaluation demonstrates that our system performs well in terms of accuracy of advice for the protocols and medications.

Simon Le Cleac'h, Taylor Howell, Shuo Yang et al.

We present a general approach for controlling robotic systems that make and break contact with their environments. Contact-implicit model predictive control (CI-MPC) generalizes linear MPC to contact-rich settings by utilizing a bi-level planning formulation with lower-level contact dynamics formulated as time-varying linear complementarity problems (LCPs) computed using strategic Taylor approximations about a reference trajectory. These dynamics enable the upper-level planning problem to reason about contact timing and forces, and generate entirely new contact-mode sequences online. To achieve reliable and fast numerical convergence, we devise a structure-exploiting interior-point solver for these LCP contact dynamics and a custom trajectory optimizer for the tracking problem. We demonstrate real-time solution rates for CI-MPC and the ability to generate and track non-periodic behaviours in hardware experiments on a quadrupedal robot. We also show that the controller is robust to model mismatch and can respond to disturbances by discovering and exploiting new contact modes across a variety of robotic systems in simulation, including a pushbot, planar hopper, planar quadruped, and planar biped.