Min Liu

Junyu Chen, Shuwen Wei, Joel Honkamaa et al.

Medical image challenges have played a transformative role in advancing the field, catalyzing algorithmic innovation and establishing new performance standards across diverse clinical applications. Image registration, a foundational task in neuroimaging pipelines, has similarly benefited from the Learn2Reg initiative. Building on this foundation, we introduce the Large-scale Unsupervised Brain MRI Image Registration (LUMIR) challenge, a next-generation benchmark designed to assess and advance unsupervised brain MRI registration. Distinct from prior challenges that leveraged anatomical label maps for supervision, LUMIR removes this dependency by providing over 4,000 preprocessed T1-weighted brain MRIs for training without any label maps, encouraging biologically plausible deformation modeling through self-supervision. In addition to evaluating performance on 590 held-out test subjects, LUMIR introduces a rigorous suite of zero-shot generalization tasks, spanning out-of-domain imaging modalities (e.g., FLAIR, T2-weighted, T2*-weighted), disease populations (e.g., Alzheimer's disease), acquisition protocols (e.g., 9.4T MRI), and species (e.g., macaque brains). A total of 1,158 subjects and over 4,000 image pairs were included for evaluation. Performance was assessed using both segmentation-based metrics (Dice coefficient, 95th percentile Hausdorff distance) and landmark-based registration accuracy (target registration error). Across both in-domain and zero-shot tasks, deep learning-based methods consistently achieved state-of-the-art accuracy while producing anatomically plausible deformation fields. The top-performing deep learning-based models demonstrated diffeomorphic properties and inverse consistency, outperforming several leading optimization-based methods, and showing strong robustness to most domain shifts, the exception being a drop in performance on out-of-domain contrasts.

Min Liu, Yifei Shi, Lintao Zheng et al.

Active vision is inherently attention-driven: The agent actively selects views to attend in order to fast achieve the vision task while improving its internal representation of the scene being observed. Inspired by the recent success of attention-based models in 2D vision tasks based on single RGB images, we propose to address the multi-view depth-based active object recognition using attention mechanism, through developing an end-to-end recurrent 3D attentional network. The architecture takes advantage of a recurrent neural network (RNN) to store and update an internal representation. Our model, trained with 3D shape datasets, is able to iteratively attend to the best views targeting an object of interest for recognizing it. To realize 3D view selection, we derive a 3D spatial transformer network which is differentiable for training with backpropagation, achieving much faster convergence than the reinforcement learning employed by most existing attention-based models. Experiments show that our method, with only depth input, achieves state-of-the-art next-best-view performance in time efficiency and recognition accuracy.