DISC-MedLLM: Bridging General Large Language Models and Real-World Medical ConsultationZhijie Bao, Wei Chen, Shengze Xiao et al.
We propose DISC-MedLLM, a comprehensive solution that leverages Large Language Models (LLMs) to provide accurate and truthful medical response in end-to-end conversational healthcare services. To construct high-quality Supervised Fine-Tuning (SFT) datasets, we employ three strategies: utilizing medical knowledge-graphs, reconstructing real-world dialogues, and incorporating human-guided preference rephrasing. These datasets are instrumental in training DISC-MedLLM, surpassing existing medical LLMs in both single-turn and multi-turn consultation scenarios. Extensive experimental results demonstrate the effectiveness of the proposed model in bridging the gap between general language models and real-world medical consultation. Additionally, we release the constructed dataset and model weights to further contribute to research and development. Further details and resources can be found at https://github.com/FudanDISC/DISC-MedLLM
A Benchmark for Automatic Medical Consultation System: Frameworks, Tasks and DatasetsWei Chen, Zhiwei Li, Hongyi Fang et al.
In recent years, interest has arisen in using machine learning to improve the efficiency of automatic medical consultation and enhance patient experience. In this article, we propose two frameworks to support automatic medical consultation, namely doctor-patient dialogue understanding and task-oriented interaction. We create a new large medical dialogue dataset with multi-level finegrained annotations and establish five independent tasks, including named entity recognition, dialogue act classification, symptom label inference, medical report generation and diagnosis-oriented dialogue policy. We report a set of benchmark results for each task, which shows the usability of the dataset and sets a baseline for future studies. Both code and data is available from https://github.com/lemuria-wchen/imcs21.
DialogVED: A Pre-trained Latent Variable Encoder-Decoder Model for Dialog Response GenerationWei Chen, Yeyun Gong, Song Wang et al. · microsoft-research
Dialog response generation in open domain is an important research topic where the main challenge is to generate relevant and diverse responses. In this paper, we propose a new dialog pre-training framework called DialogVED, which introduces continuous latent variables into the enhanced encoder-decoder pre-training framework to increase the relevance and diversity of responses. With the help of a large dialog corpus (Reddit), we pre-train the model using the following 4 tasks adopted in language models (LMs) and variational autoencoders (VAEs): 1) masked language model; 2) response generation; 3) bag-of-words prediction; and 4) KL divergence reduction. We also add additional parameters to model the turn structure in dialogs to improve the performance of the pre-trained model. We conduct experiments on PersonaChat, DailyDialog, and DSTC7-AVSD benchmarks for response generation. Experimental results show that our model achieves the new state-of-the-art results on all these datasets.
DISC-FinLLM: A Chinese Financial Large Language Model based on Multiple Experts Fine-tuningWei Chen, Qiushi Wang, Zefei Long et al.
We propose Multiple Experts Fine-tuning Framework to build a financial large language model (LLM), DISC-FinLLM. Our methodology improves general LLMs by endowing them with multi-turn question answering abilities, domain text processing capabilities, mathematical computation skills, and retrieval-enhanced generation capabilities. We build a financial instruction-tuning dataset named DISC-FIN-SFT, including instruction samples of four categories (consulting, NLP tasks, computing and retrieval-augmented generation). Evaluations conducted on multiple benchmarks demonstrate that our model performs better than baseline models in various financial scenarios. Further resources can be found at https://github.com/FudanDISC/DISC-FinLLM.
DxFormer: A Decoupled Automatic Diagnostic System Based on Decoder-Encoder Transformer with Dense Symptom RepresentationsWei Chen, Cheng Zhong, Jiajie Peng et al.
Diagnosis-oriented dialogue system queries the patient's health condition and makes predictions about possible diseases through continuous interaction with the patient. A few studies use reinforcement learning (RL) to learn the optimal policy from the joint action space of symptoms and diseases. However, existing RL (or Non-RL) methods cannot achieve sufficiently good prediction accuracy, still far from its upper limit. To address the problem, we propose a decoupled automatic diagnostic framework DxFormer, which divides the diagnosis process into two steps: symptom inquiry and disease diagnosis, where the transition from symptom inquiry to disease diagnosis is explicitly determined by the stopping criteria. In DxFormer, we treat each symptom as a token, and formalize the symptom inquiry and disease diagnosis to a language generation model and a sequence classification model respectively. We use the inverted version of Transformer, i.e., the decoder-encoder structure, to learn the representation of symptoms by jointly optimizing the reinforce reward and cross entropy loss. Extensive experiments on three public real-world datasets prove that our proposed model can effectively learn doctors' clinical experience and achieve the state-of-the-art results in terms of symptom recall and diagnostic accuracy.
1.7CLMar 17, 2023
Learning towards Selective Data Augmentation for Dialogue GenerationXiuying Chen, Mingzhe Li, Jiayi Zhang et al.
As it is cumbersome and expensive to acquire a huge amount of data for training neural dialog models, data augmentation is proposed to effectively utilize existing training samples. However, current data augmentation techniques on the dialog generation task mostly augment all cases in the training dataset without considering the intrinsic attributes between different cases. We argue that not all cases are beneficial for augmentation task, and the cases suitable for augmentation should obey the following two attributes: (1) low-quality (the dialog model cannot generate a high-quality response for the case), (2) representative (the case should represent the property of the whole dataset). Herein, we explore this idea by proposing a Selective Data Augmentation framework (SDA) for the response generation task. SDA employs a dual adversarial network to select the lowest quality and most representative data points for augmentation in one stage. Extensive experiments conducted on two publicly available datasets, i.e., DailyDialog and OpenSubtitles, show that our framework can improve the response generation performance with respect to various metrics.
Inducing Causal Structure for Abstractive Text SummarizationLu Chen, Ruqing Zhang, Wei Huang et al.
The mainstream of data-driven abstractive summarization models tends to explore the correlations rather than the causal relationships. Among such correlations, there can be spurious ones which suffer from the language prior learned from the training corpus and therefore undermine the overall effectiveness of the learned model. To tackle this issue, we introduce a Structural Causal Model (SCM) to induce the underlying causal structure of the summarization data. We assume several latent causal factors and non-causal factors, representing the content and style of the document and summary. Theoretically, we prove that the latent factors in our SCM can be identified by fitting the observed training data under certain conditions. On the basis of this, we propose a Causality Inspired Sequence-to-Sequence model (CI-Seq2Seq) to learn the causal representations that can mimic the causal factors, guiding us to pursue causal information for summary generation. The key idea is to reformulate the Variational Auto-encoder (VAE) to fit the joint distribution of the document and summary variables from the training corpus. Experimental results on two widely used text summarization datasets demonstrate the advantages of our approach.
C3KG: A Chinese Commonsense Conversation Knowledge GraphDawei Li, Yanran Li, Jiayi Zhang et al.
Existing commonsense knowledge bases often organize tuples in an isolated manner, which is deficient for commonsense conversational models to plan the next steps. To fill the gap, we curate a large-scale multi-turn human-written conversation corpus, and create the first Chinese commonsense conversation knowledge graph which incorporates both social commonsense knowledge and dialog flow information. To show the potential of our graph, we develop a graph-conversation matching approach, and benchmark two graph-grounded conversational tasks.
Large Language Models for Generative Information Extraction: A SurveyDerong Xu, Wei Chen, Wenjun Peng et al.
Information extraction (IE) aims to extract structural knowledge from plain natural language texts. Recently, generative Large Language Models (LLMs) have demonstrated remarkable capabilities in text understanding and generation. As a result, numerous works have been proposed to integrate LLMs for IE tasks based on a generative paradigm. To conduct a comprehensive systematic review and exploration of LLM efforts for IE tasks, in this study, we survey the most recent advancements in this field. We first present an extensive overview by categorizing these works in terms of various IE subtasks and techniques, and then we empirically analyze the most advanced methods and discover the emerging trend of IE tasks with LLMs. Based on a thorough review conducted, we identify several insights in technique and promising research directions that deserve further exploration in future studies. We maintain a public repository and consistently update related works and resources on GitHub (\href{https://github.com/quqxui/Awesome-LLM4IE-Papers}{LLM4IE repository})
8.3ROAug 2, 2024
A Backbone for Long-Horizon Robot Task UnderstandingXiaoshuai Chen, Wei Chen, Dongmyoung Lee et al.
End-to-end robot learning, particularly for long-horizon tasks, often results in unpredictable outcomes and poor generalization. To address these challenges, we propose a novel Therblig-Based Backbone Framework (TBBF) as a fundamental structure to enhance interpretability, data efficiency, and generalization in robotic systems. TBBF utilizes expert demonstrations to enable therblig-level task decomposition, facilitate efficient action-object mapping, and generate adaptive trajectories for new scenarios. The approach consists of two stages: offline training and online testing. During the offline training stage, we developed the Meta-RGate SynerFusion (MGSF) network for accurate therblig segmentation across various tasks. In the online testing stage, after a one-shot demonstration of a new task is collected, our MGSF network extracts high-level knowledge, which is then encoded into the image using Action Registration (ActionREG). Additionally, Large Language Model (LLM)-Alignment Policy for Visual Correction (LAP-VC) is employed to ensure precise action registration, facilitating trajectory transfer in novel robot scenarios. Experimental results validate these methods, achieving 94.37% recall in therblig segmentation and success rates of 94.4% and 80% in real-world online robot testing for simple and complex scenarios, respectively. Supplementary material is available at: https://sites.google.com/view/therbligsbasedbackbone/home
CoMAE: A Multi-factor Hierarchical Framework for Empathetic Response GenerationChujie Zheng, Yong Liu, Wei Chen et al.
The capacity of empathy is crucial to the success of open-domain dialog systems. Due to its nature of multi-dimensionality, there are various factors that relate to empathy expression, such as communication mechanism, dialog act and emotion. However, existing methods for empathetic response generation usually either consider only one empathy factor or ignore the hierarchical relationships between different factors, leading to a weak ability of empathy modeling. In this paper, we propose a multi-factor hierarchical framework, CoMAE, for empathetic response generation, which models the above three key factors of empathy expression in a hierarchical way. We show experimentally that our CoMAE-based model can generate more empathetic responses than previous methods. We also highlight the importance of hierarchical modeling of different factors through both the empirical analysis on a real-life corpus and the extensive experiments. Our codes and used data are available at https://github.com/chujiezheng/CoMAE.
Hierarchical Reinforcement Learning for Automatic Disease DiagnosisCheng Zhong, Kangenbei Liao, Wei Chen et al.
Motivation: Disease diagnosis oriented dialogue system models the interactive consultation procedure as Markov Decision Process and reinforcement learning algorithms are used to solve the problem. Existing approaches usually employ a flat policy structure that treat all symptoms and diseases equally for action making. This strategy works well in the simple scenario when the action space is small, however, its efficiency will be challenged in the real environment. Inspired by the offline consultation process, we propose to integrate a hierarchical policy structure of two levels into the dialogue systemfor policy learning. The high-level policy consists of amastermodel that is responsible for triggering a low-levelmodel, the lowlevel policy consists of several symptom checkers and a disease classifier. The proposed policy structure is capable to deal with diagnosis problem including large number of diseases and symptoms. Results: Experimental results on three real-world datasets and a synthetic dataset demonstrate that our hierarchical framework achieves higher accuracy and symptom recall in disease diagnosis compared with existing systems. We construct a benchmark including datasets and implementation of existing algorithms to encourage follow-up researches. Availability: The code and data is available from https://github.com/FudanDISC/DISCOpen-MedBox-DialoDiagnosis Contact: 21210980124@m.fudan.edu.cn Supplementary information: Supplementary data are available at Bioinformatics online.
21.8CLFeb 15, 2024
Model Compression and Efficient Inference for Large Language Models: A SurveyWenxiao Wang, Wei Chen, Yicong Luo et al.
Transformer based large language models have achieved tremendous success. However, the significant memory and computational costs incurred during the inference process make it challenging to deploy large models on resource-constrained devices. In this paper, we investigate compression and efficient inference methods for large language models from an algorithmic perspective. Regarding taxonomy, similar to smaller models, compression and acceleration algorithms for large language models can still be categorized into quantization, pruning, distillation, compact architecture design, dynamic networks. However, Large language models have two prominent characteristics compared to smaller models: (1) Most of compression algorithms require finetuning or even retraining the model after compression. The most notable aspect of large models is the very high cost associated with model finetuning or training. Therefore, many algorithms for large models, such as quantization and pruning, start to explore tuning-free algorithms. (2) Large models emphasize versatility and generalization rather than performance on a single task. Hence, many algorithms, such as knowledge distillation, focus on how to preserving their versatility and generalization after compression. Since these two characteristics were not very pronounced in early large models, we further distinguish large language models into medium models and ``real'' large models. Additionally, we also provide an introduction to some mature frameworks for efficient inference of large models, which can support basic compression or acceleration algorithms, greatly facilitating model deployment for users.
0.9CLApr 4, 2023
Blockwise Compression of Transformer-based Models without RetrainingGaochen Dong, Wei Chen
Transformer-based models, exemplified by GPT-3, ChatGPT, and GPT-4, have recently garnered considerable attention in both academia and industry due to their promising performance in general language tasks. Nevertheless, these models typically involve computationally encoding processes, and in some cases, decoding processes as well, both of which are fundamentally large-scale matrix multiplication. These operations bring the inevitable challenges of massive computation resources and huge memory footprint, usually requiring at least 10^23 FLOPs and hundreds of gigabytes, respectively. A common method to address this issue is to reduce the computational and memory requirements by applying layerwise quantization to the transformer, replacing the usual fp32 data type with a low-bit equivalent. Unfortunately, this method often leads to decreased model accuracy and necessitates time-consuming retraining. Such retraining not only requires fine-tuning skills but also substantial computational resources, posing challenges for users. To specifically tackle these issues, we propose BCT, a framework of blockwise compression for transformers without retraining, aiming to facilitate model deployment. Unlike layerwise compression methods, BCT achieves finer compression of the entire transformer by operating blockwise. This method mitigates data distribution deviation caused by quantization, eliminating the requirement for retraining. BCT effectively compresses all components of the model, including but not limited to the embedding, matrix multiplication, GELU, Softmax, layer normalization, and intermediate results. In a case study, an efficient model is compressed by BCT achieving up to 7.988x compression. Subsequently, we also evaluate it on several General Language Understanding Evaluation (GLUE) datasets.
OCRBench v2: An Improved Benchmark for Evaluating Large Multimodal Models on Visual Text Localization and ReasoningLing Fu, Zhebin Kuang, Jiajun Song et al.
Scoring the Optical Character Recognition (OCR) capabilities of Large Multimodal Models (LMMs) has witnessed growing interest. Existing benchmarks have highlighted the impressive performance of LMMs in text recognition; however, their abilities in certain challenging tasks, such as text localization, handwritten content extraction, and logical reasoning, remain underexplored. To bridge this gap, we introduce OCRBench v2, a large-scale bilingual text-centric benchmark with currently the most comprehensive set of tasks (4x more tasks than the previous multi-scene benchmark OCRBench), the widest coverage of scenarios (31 diverse scenarios), and thorough evaluation metrics, with 10,000 human-verified question-answering pairs and a high proportion of difficult samples. Moreover, we construct a private test set with 1,500 manually annotated images. The consistent evaluation trends observed across both public and private test sets validate the OCRBench v2's reliability. After carefully benchmarking state-of-the-art LMMs, we find that most LMMs score below 50 (100 in total) and suffer from five-type limitations, including less frequently encountered text recognition, fine-grained perception, layout perception, complex element parsing, and logical reasoning. The project website is at: https://99franklin.github.io/ocrbench_v2/
13.8CLDec 18, 2023
Tuning LayerNorm in Attention: Towards Efficient Multi-Modal LLM FinetuningBingchen Zhao, Haoqin Tu, Chen Wei et al.
This paper introduces an efficient strategy to transform Large Language Models (LLMs) into Multi-Modal Large Language Models (MLLMs). By conceptualizing this transformation as a domain adaptation process, i.e., transitioning from text understanding to embracing multiple modalities, we intriguingly note that, within each attention block, tuning LayerNorm suffices to yield strong performance. Moreover, when benchmarked against other tuning approaches like full parameter finetuning or LoRA, its benefits on efficiency are substantial. For example, when compared to LoRA on a 13B model scale, performance can be enhanced by an average of over 20% across five multi-modal tasks, and meanwhile, results in a significant reduction of trainable parameters by 41.9% and a decrease in GPU memory usage by 17.6%. On top of this LayerNorm strategy, we showcase that selectively tuning only with conversational data can improve efficiency further. Beyond these empirical outcomes, we provide a comprehensive analysis to explore the role of LayerNorm in adapting LLMs to the multi-modal domain and improving the expressive power of the model.
11.4LGMay 29, 2025
SCORPIO: Serving the Right Requests at the Right Time for Heterogeneous SLOs in LLM InferenceYinghao Tang, Tingfeng Lan, Xiuqi Huang et al.
Existing Large Language Model (LLM) serving systems prioritize maximum throughput. They often neglect Service Level Objectives (SLOs) such as Time to First Token (TTFT) and Time Per Output Token (TPOT), which leads to suboptimal SLO attainment. This paper introduces SCORPIO, an SLO-oriented LLM serving system designed to maximize system goodput and SLO attainment for workloads with heterogeneous SLOs. Our core insight is to exploit SLO heterogeneity for adaptive scheduling across admission control, queue management, and batch selection. SCORPIO features a TTFT Guard, which employs least-deadline-first reordering and rejects unattainable requests, and a TPOT Guard, which utilizes a VBS-based admission control and a novel credit-based batching mechanism. Both guards are supported by a predictive module. Evaluations demonstrate that SCORPIO improves system goodput by up to 14.4X and SLO adherence by up to 46.5% compared to state-of-the-art baselines.
26.3CLMay 26, 2023
KNSE: A Knowledge-aware Natural Language Inference Framework for Dialogue Symptom Status RecognitionWei Chen, Shiqi Wei, Zhongyu Wei et al.
Symptom diagnosis in medical conversations aims to correctly extract both symptom entities and their status from the doctor-patient dialogue. In this paper, we propose a novel framework called KNSE for symptom status recognition (SSR), where the SSR is formulated as a natural language inference (NLI) task. For each mentioned symptom in a dialogue window, we first generate knowledge about the symptom and hypothesis about status of the symptom, to form a (premise, knowledge, hypothesis) triplet. The BERT model is then used to encode the triplet, which is further processed by modules including utterance aggregation, self-attention, cross-attention, and GRU to predict the symptom status. Benefiting from the NLI formalization, the proposed framework can encode more informative prior knowledge to better localize and track symptom status, which can effectively improve the performance of symptom status recognition. Preliminary experiments on Chinese medical dialogue datasets show that KNSE outperforms previous competitive baselines and has advantages in cross-disease and cross-symptom scenarios.
Contextual Fine-to-Coarse Distillation for Coarse-grained Response Selection in Open-Domain ConversationsWei Chen, Yeyun Gong, Can Xu et al.
We study the problem of coarse-grained response selection in retrieval-based dialogue systems. The problem is equally important with fine-grained response selection, but is less explored in existing literature. In this paper, we propose a Contextual Fine-to-Coarse (CFC) distilled model for coarse-grained response selection in open-domain conversations. In our CFC model, dense representations of query, candidate response and corresponding context is learned based on the multi-tower architecture, and more expressive knowledge learned from the one-tower architecture (fine-grained) is distilled into the multi-tower architecture (coarse-grained) to enhance the performance of the retriever. To evaluate the performance of our proposed model, we construct two new datasets based on the Reddit comments dump and Twitter corpus. Extensive experimental results on the two datasets show that the proposed methods achieve a significant improvement over all evaluation metrics compared with traditional baseline methods.
30.7CLSep 12, 2021
End-to-End Conversational Search for Online Shopping with Utterance TransferLiqiang Xiao, Jun Ma2, Xin Luna Dong et al.
Successful conversational search systems can present natural, adaptive and interactive shopping experience for online shopping customers. However, building such systems from scratch faces real word challenges from both imperfect product schema/knowledge and lack of training dialog data.In this work we first propose ConvSearch, an end-to-end conversational search system that deeply combines the dialog system with search. It leverages the text profile to retrieve products, which is more robust against imperfect product schema/knowledge compared with using product attributes alone. We then address the lack of data challenges by proposing an utterance transfer approach that generates dialogue utterances by using existing dialog from other domains, and leveraging the search behavior data from e-commerce retailer. With utterance transfer, we introduce a new conversational search dataset for online shopping. Experiments show that our utterance transfer method can significantly improve the availability of training dialogue data without crowd-sourcing, and the conversational search system significantly outperformed the best tested baseline.
3.6CLMay 11, 2021
Towards an Online Empathetic Chatbot with Emotion CausesYanran Li, Ke Li, Hongke Ning et al.
Existing emotion-aware conversational models usually focus on controlling the response contents to align with a specific emotion class, whereas empathy is the ability to understand and concern the feelings and experience of others. Hence, it is critical to learn the causes that evoke the users' emotion for empathetic responding, a.k.a. emotion causes. To gather emotion causes in online environments, we leverage counseling strategies and develop an empathetic chatbot to utilize the causal emotion information. On a real-world online dataset, we verify the effectiveness of the proposed approach by comparing our chatbot with several SOTA methods using automatic metrics, expert-based human judgements as well as user-based online evaluation.
25.6CLDec 31, 2020
FGraDA: A Dataset and Benchmark for Fine-Grained Domain Adaptation in Machine TranslationWenhao Zhu, Shujian Huang, Tong Pu et al.
Previous research for adapting a general neural machine translation (NMT) model into a specific domain usually neglects the diversity in translation within the same domain, which is a core problem for domain adaptation in real-world scenarios. One representative of such challenging scenarios is to deploy a translation system for a conference with a specific topic, e.g., global warming or coronavirus, where there are usually extremely less resources due to the limited schedule. To motivate wider investigation in such a scenario, we present a real-world fine-grained domain adaptation task in machine translation (FGraDA). The FGraDA dataset consists of Chinese-English translation task for four sub-domains of information technology: autonomous vehicles, AI education, real-time networks, and smart phone. Each sub-domain is equipped with a development set and test set for evaluation purposes. To be closer to reality, FGraDA does not employ any in-domain bilingual training data but provides bilingual dictionaries and wiki knowledge base, which can be easier obtained within a short time. We benchmark the fine-grained domain adaptation task and present in-depth analyses showing that there are still challenging problems to further improve the performance with heterogeneous resources.
Writing Polishment with Simile: Task, Dataset and A Neural ApproachJiayi Zhang, Zhi Cui, Xiaoqiang Xia et al.
A simile is a figure of speech that directly makes a comparison, showing similarities between two different things, e.g. "Reading papers can be dull sometimes,like watching grass grow". Human writers often interpolate appropriate similes into proper locations of the plain text to vivify their writings. However, none of existing work has explored neural simile interpolation, including both locating and generation. In this paper, we propose a new task of Writing Polishment with Simile (WPS) to investigate whether machines are able to polish texts with similes as we human do. Accordingly, we design a two-staged Locate&Gen model based on transformer architecture. Our model firstly locates where the simile interpolation should happen, and then generates a location-specific simile. We also release a large-scale Chinese Simile (CS) dataset containing 5 million similes with context. The experimental results demonstrate the feasibility of WPS task and shed light on the future research directions towards better automatic text polishment.
Reasoning in Dialog: Improving Response Generation by Context Reading ComprehensionXiuying Chen, Zhi Cui, Jiayi Zhang et al.
In multi-turn dialog, utterances do not always take the full form of sentences \cite{Carbonell1983DiscoursePA}, which naturally makes understanding the dialog context more difficult. However, it is essential to fully grasp the dialog context to generate a reasonable response. Hence, in this paper, we propose to improve the response generation performance by examining the model's ability to answer a reading comprehension question, where the question is focused on the omitted information in the dialog. Enlightened by the multi-task learning scheme, we propose a joint framework that unifies these two tasks, sharing the same encoder to extract the common and task-invariant features with different decoders to learn task-specific features. To better fusing information from the question and the dialog history in the encoding part, we propose to augment the Transformer architecture with a memory updater, which is designed to selectively store and update the history dialog information so as to support downstream tasks. For the experiment, we employ human annotators to write and examine a large-scale dialog reading comprehension dataset. Extensive experiments are conducted on this dataset, and the results show that the proposed model brings substantial improvements over several strong baselines on both tasks. In this way, we demonstrate that reasoning can indeed help better response generation and vice versa. We release our large-scale dataset for further research.
Focus-Constrained Attention Mechanism for CVAE-based Response GenerationZhi Cui, Yanran Li, Jiayi Zhang et al.
To model diverse responses for a given post, one promising way is to introduce a latent variable into Seq2Seq models. The latent variable is supposed to capture the discourse-level information and encourage the informativeness of target responses. However, such discourse-level information is often too coarse for the decoder to be utilized. To tackle it, our idea is to transform the coarse-grained discourse-level information into fine-grained word-level information. Specifically, we firstly measure the semantic concentration of corresponding target response on the post words by introducing a fine-grained focus signal. Then, we propose a focus-constrained attention mechanism to take full advantage of focus in well aligning the input to the target response. The experimental results demonstrate that by exploiting the fine-grained signal, our model can generate more diverse and informative responses compared with several state-of-the-art models.