Peng Liu

Lin Ding, Peng Liu, Wenfeng Shen et al.

Model-Agnostic Meta-Learning (MAML) is one of the most successful meta-learning techniques for few-shot learning. It uses gradient descent to learn commonalities between various tasks, enabling the model to learn the meta-initialization of its own parameters to quickly adapt to new tasks using a small amount of labeled training data. A key challenge to few-shot learning is task uncertainty. Although a strong prior can be obtained from meta-learning with a large number of tasks, a precision model of the new task cannot be guaranteed because the volume of the training dataset is normally too small. In this study, first,in the process of choosing initialization parameters, the new method is proposed for task-specific learner adaptively learn to select initialization parameters that minimize the loss of new tasks. Then, we propose two improved methods for the meta-loss part: Method 1 generates weights by comparing meta-loss differences to improve the accuracy when there are few classes, and Method 2 introduces the homoscedastic uncertainty of each task to weigh multiple losses based on the original gradient descent,as a way to enhance the generalization ability to novel classes while ensuring accuracy improvement. Compared with previous gradient-based meta-learning methods, our model achieves better performance in regression tasks and few-shot classification and improves the robustness of the model to the learning rate and query sets in the meta-test set.

Peng Liu, Ruogu Fang

Observing retinal fundus images by an ophthalmologist is a major diagnosis approach for glaucoma. However, it is still difficult to distinguish the features of the lesion solely through manual observations, especially, in glaucoma early phase. In this paper, we present two deep learning-based automated algorithms for glaucoma detection and optic disc and cup segmentation. We utilize the attention mechanism to learn pixel-wise features for accurate prediction. In particular, we present two convolutional neural networks that can focus on learning various pixel-wise level features. In addition, we develop several attention strategies to guide the networks to learn the important features that have a major impact on prediction accuracy. We evaluate our methods on the validation dataset and The proposed both tasks' solutions can achieve impressive results and outperform current state-of-the-art methods. \textit{The code is available at \url{https://github.com/cswin/RLPA}}.

Peng Liu, Bin Kong, Zhongyu Li et al.

Recently, deep neural networks have demonstrated comparable and even better performance with board-certified ophthalmologists in well-annotated datasets. However, the diversity of retinal imaging devices poses a significant challenge: domain shift, which leads to performance degradation when applying the deep learning models to new testing domains. In this paper, we propose a novel unsupervised domain adaptation framework, called Collaborative Feature Ensembling Adaptation (CFEA), to effectively overcome this challenge. Our proposed CFEA is an interactive paradigm which presents an exquisite of collaborative adaptation through both adversarial learning and ensembling weights. In particular, we simultaneously achieve domain-invariance and maintain an exponential moving average of the historical predictions, which achieves a better prediction for the unlabeled data, via ensembling weights during training. Without annotating any sample from the target domain, multiple adversarial losses in encoder and decoder layers guide the extraction of domain-invariant features to confuse the domain classifier and meanwhile benefit the ensembling of smoothing weights. Comprehensive experimental results demonstrate that our CFEA model can overcome performance degradation and outperform the state-of-the-art methods in segmenting retinal optic disc and cup from fundus images. \textit{Code is available at \url{https://github.com/cswin/AWC}}.

José Ignacio Orlando, Huazhu Fu, João Barbossa Breda et al.

Glaucoma is one of the leading causes of irreversible but preventable blindness in working age populations. Color fundus photography (CFP) is the most cost-effective imaging modality to screen for retinal disorders. However, its application to glaucoma has been limited to the computation of a few related biomarkers such as the vertical cup-to-disc ratio. Deep learning approaches, although widely applied for medical image analysis, have not been extensively used for glaucoma assessment due to the limited size of the available data sets. Furthermore, the lack of a standardize benchmark strategy makes difficult to compare existing methods in a uniform way. In order to overcome these issues we set up the Retinal Fundus Glaucoma Challenge, REFUGE (\url{https://refuge.grand-challenge.org}), held in conjunction with MICCAI 2018. The challenge consisted of two primary tasks, namely optic disc/cup segmentation and glaucoma classification. As part of REFUGE, we have publicly released a data set of 1200 fundus images with ground truth segmentations and clinical glaucoma labels, currently the largest existing one. We have also built an evaluation framework to ease and ensure fairness in the comparison of different models, encouraging the development of novel techniques in the field. 12 teams qualified and participated in the online challenge. This paper summarizes their methods and analyzes their corresponding results. In particular, we observed that two of the top-ranked teams outperformed two human experts in the glaucoma classification task. Furthermore, the segmentation results were in general consistent with the ground truth annotations, with complementary outcomes that can be further exploited by ensembling the results.