Juan Wang

Juan Wang, Bin Xia

The cup-to-disc ratio (CDR) is one of the most significant indicator for glaucoma diagnosis. Different from the use of costly fully supervised learning formulation with pixel-wise annotations in the literature, this study investigates the feasibility of accurate CDR measurement in fundus images using only tight bounding box supervision. For this purpose, we develop a two-task network named as CDRNet for accurate CDR measurement, one for weakly supervised image segmentation, and the other for bounding-box regression. The weakly supervised image segmentation task is implemented based on generalized multiple instance learning formulation and smooth maximum approximation, and the bounding-box regression task outputs class-specific bounding box prediction in a single scale at the original image resolution. To get accurate bounding box prediction, a class-specific bounding-box normalizer and an expected intersection-over-union are proposed. In the experiments, the proposed approach was evaluated by a testing set with 1200 images using CDR error and $F_1$ score for CDR measurement and dice coefficient for image segmentation. A grader study was conducted to compare the performance of the proposed approach with those of individual graders. The experimental results indicate that the proposed approach outperforms the state-of-the-art performance obtained from the fully supervised image segmentation (FSIS) approach using pixel-wise annotation for CDR measurement. Its performance is also better than those of individual graders. In addition, the proposed approach gets performance close to the state-of-the-art obtained from FSIS and the performance of individual graders for optic cup and disc segmentation. The codes are available at \url{https://github.com/wangjuan313/CDRNet}.

Juan Wang, Bin Xia

This paper presents a weakly supervised image segmentation method that adopts tight bounding box annotations. It proposes generalized multiple instance learning (MIL) and smooth maximum approximation to integrate the bounding box tightness prior into the deep neural network in an end-to-end manner. In generalized MIL, positive bags are defined by parallel crossing lines with a set of different angles, and negative bags are defined as individual pixels outside of any bounding boxes. Two variants of smooth maximum approximation, i.e., $α$-softmax function and $α$-quasimax function, are exploited to conquer the numeral instability introduced by maximum function of bag prediction. The proposed approach was evaluated on two pubic medical datasets using Dice coefficient. The results demonstrate that it outperforms the state-of-the-art methods. The codes are available at \url{https://github.com/wangjuan313/wsis-boundingbox}.

Yaozu Ye, Kailun Yang, Kaite Xiang et al.

Semantic segmentation is a critical method in the field of autonomous driving. When performing semantic image segmentation, a wider field of view (FoV) helps to obtain more information about the surrounding environment, making automatic driving safer and more reliable, which could be offered by fisheye cameras. However, large public fisheye datasets are not available, and the fisheye images captured by the fisheye camera with large FoV comes with large distortion, so commonly-used semantic segmentation model cannot be directly utilized. In this paper, a seven degrees of freedom (DoF) augmentation method is proposed to transform rectilinear image to fisheye image in a more comprehensive way. In the training process, rectilinear images are transformed into fisheye images in seven DoF, which simulates the fisheye images taken by cameras of different positions, orientations and focal lengths. The result shows that training with the seven-DoF augmentation can improve the model's accuracy and robustness against different distorted fisheye data. This seven-DoF augmentation provides a universal semantic segmentation solution for fisheye cameras in different autonomous driving applications. Also, we provide specific parameter settings of the augmentation for autonomous driving. At last, we tested our universal semantic segmentation model on real fisheye images and obtained satisfactory results. The code and configurations are released at https://github.com/Yaozhuwa/FisheyeSeg.

Weiji Kong, Xun Gong, Juan Wang

Explaining the decisions of Deep Neural Networks (DNNs) for medical images has become increasingly important. Existing attribution methods have difficulty explaining the meaning of pixels while existing concept-based methods are limited by additional annotations or specific model structures that are difficult to apply to ultrasound images. In this paper, we propose the Lesion Concept Explainer (LCE) framework, which combines attribution methods with concept-based methods. We introduce the Segment Anything Model (SAM), fine-tuned on a large number of medical images, for concept discovery to enable a meaningful explanation of ultrasound image DNNs. The proposed framework is evaluated in terms of both faithfulness and understandability. We point out deficiencies in the popular faithfulness evaluation metrics and propose a new evaluation metric. Our evaluation of public and private breast ultrasound datasets (BUSI and FG-US-B) shows that LCE performs well compared to commonly-used explainability methods. Finally, we also validate that LCE can consistently provide reliable explanations for more meaningful fine-grained diagnostic tasks in breast ultrasound.