Hao Li

Hao Li, Yang Nan, Javier Del Ser et al.

Automatic segmentation of multiple organs and tumors from 3D medical images such as magnetic resonance imaging (MRI) and computed tomography (CT) scans using deep learning methods can aid in diagnosing and treating cancer. However, organs often overlap and are complexly connected, characterized by extensive anatomical variation and low contrast. In addition, the diversity of tumor shape, location, and appearance, coupled with the dominance of background voxels, makes accurate 3D medical image segmentation difficult. In this paper, a novel large-kernel (LK) attention module is proposed to address these problems to achieve accurate multi-organ segmentation and tumor segmentation. The advantages of convolution and self-attention are combined in the proposed LK attention module, including local contextual information, long-range dependence, and channel adaptation. The module also decomposes the LK convolution to optimize the computational cost and can be easily incorporated into FCNs such as U-Net. Comprehensive ablation experiments demonstrated the feasibility of convolutional decomposition and explored the most efficient and effective network design. Among them, the best Mid-type LK attention-based U-Net network was evaluated on CT-ORG and BraTS 2020 datasets, achieving state-of-the-art segmentation performance. The performance improvement due to the proposed LK attention module was also statistically validated.

Jun Li, Xiaozhu Lin, Hui Che et al.

Pancreas segmentation in medical imaging data is of great significance for clinical pancreas diagnostics and treatment. However, the large population variations in the pancreas shape and volume cause enormous segmentation difficulties, even for state-of-the-art algorithms utilizing fully-convolutional neural networks (FCNs). Specifically, pancreas segmentation suffers from the loss of spatial information in 2D methods, and the high computational cost of 3D methods. To alleviate these problems, we propose a probabilistic-map-guided bi-directional recurrent UNet (PBR-UNet) architecture, which fuses intra-slice information and inter-slice probabilistic maps into a local 3D hybrid regularization scheme, which is followed by bi-directional recurrent network optimization. The PBR-UNet method consists of an initial estimation module for efficiently extracting pixel-level probabilistic maps and a primary segmentation module for propagating hybrid information through a 2.5D U-Net architecture. Specifically, local 3D information is inferred by combining an input image with the probabilistic maps of the adjacent slices into multichannel hybrid data, and then hierarchically aggregating the hybrid information of the entire segmentation network. Besides, a bi-directional recurrent optimization mechanism is developed to update the hybrid information in both the forward and the backward directions. This allows the proposed network to make full and optimal use of the local context information. Quantitative and qualitative evaluation was performed on the NIH Pancreas-CT dataset, and our proposed PBR-UNet method achieved better segmentation results with less computational cost compared to other state-of-the-art methods.

Hao Li, Jun Li, Xiaozhu Lin et al.

The irregular geometry and high inter-slice variability in computerized tomography (CT) scans of the human pancreas make an accurate segmentation of this crucial organ a challenging task for existing data-driven deep learning methods. To address this problem, we present a novel model-driven stack-based fully convolutional network with a sliding window fusion algorithm for pancreas segmentation, termed MDS-Net. The MDS-Net's cost function includes a data approximation term and a prior knowledge regularization term combined with a stack scheme for capturing and fusing the two-dimensional (2D) and local three-dimensional (3D) context information. Specifically, 3D CT scans are divided into multiple stacks to capture the local spatial context feature. To highlight the importance of single slices, the inter-slice relationships in the stack data are also incorporated in the MDS-Net framework. For implementing this proposed model-driven method, we create a stack-based U-Net architecture and successfully derive its back-propagation procedure for end-to-end training. Furthermore, a sliding window fusion algorithm is utilized to improve the consistency of adjacent CT slices and intra-stack. Finally, extensive quantitative assessments on the NIH Pancreas-CT dataset demonstrated higher pancreatic segmentation accuracy and reliability of MDS-Net compared to other state-of-the-art methods.