Chong Chen

Jinqiu Deng, Ke Chen, Mingke Li et al.

Diffeomorphic image registration is crucial for various medical imaging applications because it can preserve the topology of the transformation. This study introduces DCCNN-LSTM-Reg, a learning framework that evolves dynamically and learns a symmetrical registration path by satisfying a specified control increment system. This framework aims to obtain symmetric diffeomorphic deformations between moving and fixed images. To achieve this, we combine deep learning networks with diffeomorphic mathematical mechanisms to create a continuous and dynamic registration architecture, which consists of multiple Symmetric Registration (SR) modules cascaded on five different scales. Specifically, our method first uses two U-nets with shared parameters to extract multiscale feature pyramids from the images. We then develop an SR-module comprising a sequential CNN-LSTM architecture to progressively correct the forward and reverse multiscale deformation fields using control increment learning and the homotopy continuation technique. Through extensive experiments on three 3D registration tasks, we demonstrate that our method outperforms existing approaches in both quantitative and qualitative evaluations.

Chong Chen

We propose a variational model with diffeomorphic optimal transportation for joint image reconstruction and motion estimation. The proposed model is a production of assembling the Wasserstein distance with the Benamou--Brenier formula in optimal transportation and the flow of diffeomorphisms involved in large deformation diffeomorphic metric mapping, which is suitable for the scenario of spatiotemporal imaging with large diffeomorphic and mass-preserving deformations. Specifically, we first use the Benamou--Brenier formula to characterize the optimal transport cost among the flow of mass-preserving images, and restrict the velocity field into the admissible Hilbert space to guarantee the generated deformation flow being diffeomorphic. We then gain the ODE-constrained equivalent formulation for Benamou--Brenier formula. We finally obtain the proposed model with ODE constraint following the framework that presented in our previous work. We further get the equivalent PDE-constrained optimal control formulation. The proposed model is compared against several existing alternatives theoretically. The alternating minimization algorithm is presented for solving the time-discretized version of the proposed model with ODE constraint. Several important issues on the proposed model and associated algorithms are also discussed. Particularly, we present several potential models based on the proposed diffeomorphic optimal transportation. Under appropriate conditions, the proposed algorithm also provides a new scheme to solve the models using quadratic Wasserstein distance. The performance is finally evaluated by several numerical experiments in space-time tomography, where the data is measured from the concerned sequential images with sparse views and/or various noise levels.

Gris Barbara, Chen Chong, Öktem Ozan

This article adapts the framework of metamorphosis to solve inverse problems in imaging that includes joint reconstruction and image registration. The deformations in question have two components, one that is a geometric deformation moving intensities and the other a deformation of intensity values itself, which, e.g., allows for appearance of a new structure. The idea developed here is to reconstruct an image from noisy and indirect observations by registering, via metamorphosis, a template to the observed data. Unlike a registration with only geometrical changes, this framework gives good results when intensities of the template are poorly chosen. We show that this method is a well-defined regularisation method (proving existence, stability and convergence) and present several numerical examples.