Donghun Lee

Eugene Vorontsov, Alican Bozkurt, Adam Casson et al.

The use of artificial intelligence to enable precision medicine and decision support systems through the analysis of pathology images has the potential to revolutionize the diagnosis and treatment of cancer. Such applications will depend on models' abilities to capture the diverse patterns observed in pathology images. To address this challenge, we present Virchow, a foundation model for computational pathology. Using self-supervised learning empowered by the DINOv2 algorithm, Virchow is a vision transformer model with 632 million parameters trained on 1.5 million hematoxylin and eosin stained whole slide images from diverse tissue and specimen types, which is orders of magnitude more data than previous works. The Virchow model enables the development of a pan-cancer detection system with 0.949 overall specimen-level AUC across 17 different cancer types, while also achieving 0.937 AUC on 7 rare cancer types. The Virchow model sets the state-of-the-art on the internal and external image tile level benchmarks and slide level biomarker prediction tasks. The gains in performance highlight the importance of training on massive pathology image datasets, suggesting scaling up the data and network architecture can improve the accuracy for many high-impact computational pathology applications where limited amounts of training data are available.

Joosung Lee, Minsik Oh, Donghun Lee

The use of persona-grounded retrieval-based chatbots is crucial for personalized conversations, but there are several challenges that need to be addressed. 1) In general, collecting persona-grounded corpus is very expensive. 2) The chatbot system does not always respond in consideration of persona at real applications. To address these challenges, we propose a plug-and-play persona prompting method. Our system can function as a standard open-domain chatbot if persona information is not available. We demonstrate that this approach performs well in the zero-shot setting, which reduces the dependence on persona-ground training data. This makes it easier to expand the system to other languages without the need to build a persona-grounded corpus. Additionally, our model can be fine-tuned for even better performance. In our experiments, the zero-shot model improved the standard model by 7.71 and 1.04 points in the original persona and revised persona, respectively. The fine-tuned model improved the previous state-of-the-art system by 1.95 and 3.39 points in the original persona and revised persona, respectively. To the best of our knowledge, this is the first attempt to solve the problem of personalized response selection using prompt sequences. Our code is available on github~\footnote{https://github.com/rungjoo/plug-and-play-prompt-persona}.

Taehun Cha, Donghun Lee

In this work, we show the pre-trained language models return distinguishable generation probability and uncertainty distribution to unfaithfully hallucinated texts, regardless of their size and structure. By examining 24 models on 6 data sets, we find out that 88-98% of cases return statistically significantly distinguishable generation probability and uncertainty distributions. Using this general phenomenon, we showcase a hallucination-reducing training algorithm. Our algorithm outperforms other baselines by achieving higher faithfulness metrics while maintaining sound general text quality measures.

Sunghee Jung, Donghun Lee, Shinbok Lee et al.

Tool-Augmented Larage Language Models (TA-LLMs) have shown promise in real-world applications, but face challenges in handling incomplete queries and out-of-scope requests. While existing approaches rely mainly on Supervised Fine-Tuning with expert trajectories, we propose DiaTool-DPO, a novel method that enhances TA-LLM's dialogue capabilities through Direct Preference Optimization. We model TA-LLM interactions as a Markov Decision Process with 5 distinct dialogue states and categorize user queries into 3 types based on their state transition trajectories. We automatically construct paired trajectory datasets of correct and incorrect dialogue flows and introduce a specialized objective loss for dialogue control. Our comprehensive evaluation demonstrates that DiaTool-DPO approaches GPT-4o's performance (94.8% in information gathering, 91% in tool call rejection) with substantial improvements over baseline (44% and 9.6% respectively) while maintaining core functionality. Our approach opens new possibilities for developing TA-LLMs that can handle diverse real-world scenarios without requiring additional expert demonstrations or human labeling.

Taesun Whang, Dongyub Lee, Dongsuk Oh et al.

In this paper, we study the task of selecting the optimal response given a user and system utterance history in retrieval-based multi-turn dialog systems. Recently, pre-trained language models (e.g., BERT, RoBERTa, and ELECTRA) showed significant improvements in various natural language processing tasks. This and similar response selection tasks can also be solved using such language models by formulating the tasks as dialog--response binary classification tasks. Although existing works using this approach successfully obtained state-of-the-art results, we observe that language models trained in this manner tend to make predictions based on the relatedness of history and candidates, ignoring the sequential nature of multi-turn dialog systems. This suggests that the response selection task alone is insufficient for learning temporal dependencies between utterances. To this end, we propose utterance manipulation strategies (UMS) to address this problem. Specifically, UMS consist of several strategies (i.e., insertion, deletion, and search), which aid the response selection model towards maintaining dialog coherence. Further, UMS are self-supervised methods that do not require additional annotation and thus can be easily incorporated into existing approaches. Extensive evaluation across multiple languages and models shows that UMS are highly effective in teaching dialog consistency, which leads to models pushing the state-of-the-art with significant margins on multiple public benchmark datasets.

Donghun Lee, Srivatsan Srinivasan, Finale Doshi-Velez

We introduce a novel apprenticeship learning algorithm to learn an expert's underlying reward structure in off-policy model-free \emph{batch} settings. Unlike existing methods that require a dynamics model or additional data acquisition for on-policy evaluation, our algorithm requires only the batch data of observed expert behavior. Such settings are common in real-world tasks---health care, finance or industrial processes ---where accurate simulators do not exist or data acquisition is costly. To address challenges in batch settings, we introduce Deep Successor Feature Networks(DSFN) that estimate feature expectations in an off-policy setting and a transition-regularized imitation network that produces a near-expert initial policy and an efficient feature representation. Our algorithm achieves superior results in batch settings on both control benchmarks and a vital clinical task of sepsis management in the Intensive Care Unit.

Omer Gottesman, Fredrik Johansson, Joshua Meier et al.

Much attention has been devoted recently to the development of machine learning algorithms with the goal of improving treatment policies in healthcare. Reinforcement learning (RL) is a sub-field within machine learning that is concerned with learning how to make sequences of decisions so as to optimize long-term effects. Already, RL algorithms have been proposed to identify decision-making strategies for mechanical ventilation, sepsis management and treatment of schizophrenia. However, before implementing treatment policies learned by black-box algorithms in high-stakes clinical decision problems, special care must be taken in the evaluation of these policies. In this document, our goal is to expose some of the subtleties associated with evaluating RL algorithms in healthcare. We aim to provide a conceptual starting point for clinical and computational researchers to ask the right questions when designing and evaluating algorithms for new ways of treating patients. In the following, we describe how choices about how to summarize a history, variance of statistical estimators, and confounders in more ad-hoc measures can result in unreliable, even misleading estimates of the quality of a treatment policy. We also provide suggestions for mitigating these effects---for while there is much promise for mining observational health data to uncover better treatment policies, evaluation must be performed thoughtfully.