Le Zhang

Zhiyu Ma, Chen Li, Tianming Du et al.

Methods: In this study, a benchmark \emph{Abdominal Adipose Tissue CT Image Dataset} (AATTCT-IDS) containing 300 subjects is prepared and published. AATTCT-IDS publics 13,732 raw CT slices, and the researchers individually annotate the subcutaneous and visceral adipose tissue regions of 3,213 of those slices that have the same slice distance to validate denoising methods, train semantic segmentation models, and study radiomics. For different tasks, this paper compares and analyzes the performance of various methods on AATTCT-IDS by combining the visualization results and evaluation data. Thus, verify the research potential of this data set in the above three types of tasks. Results: In the comparative study of image denoising, algorithms using a smoothing strategy suppress mixed noise at the expense of image details and obtain better evaluation data. Methods such as BM3D preserve the original image structure better, although the evaluation data are slightly lower. The results show significant differences among them. In the comparative study of semantic segmentation of abdominal adipose tissue, the segmentation results of adipose tissue by each model show different structural characteristics. Among them, BiSeNet obtains segmentation results only slightly inferior to U-Net with the shortest training time and effectively separates small and isolated adipose tissue. In addition, the radiomics study based on AATTCT-IDS reveals three adipose distributions in the subject population. Conclusion: AATTCT-IDS contains the ground truth of adipose tissue regions in abdominal CT slices. This open-source dataset can attract researchers to explore the multi-dimensional characteristics of abdominal adipose tissue and thus help physicians and patients in clinical practice. AATCT-IDS is freely published for non-commercial purpose at: \url{https://figshare.com/articles/dataset/AATTCT-IDS/23807256}.

Le Zhang, Jiayang Chen, Tao Shen et al. · mila

The field of protein folding research has been greatly advanced by deep learning methods, with AlphaFold2 (AF2) demonstrating exceptional performance and atomic-level precision. As co-evolution is integral to protein structure prediction, AF2's accuracy is significantly influenced by the depth of multiple sequence alignment (MSA), which requires extensive exploration of a large protein database for similar sequences. However, not all protein sequences possess abundant homologous families, and consequently, AF2's performance can degrade on such queries, at times failing to produce meaningful results. To address this, we introduce a novel generative language model, MSA-Augmenter, which leverages protein-specific attention mechanisms and large-scale MSAs to generate useful, novel protein sequences not currently found in databases. These sequences supplement shallow MSAs, enhancing the accuracy of structural property predictions. Our experiments on CASP14 demonstrate that MSA-Augmenter can generate de novo sequences that retain co-evolutionary information from inferior MSAs, thereby improving protein structure prediction quality on top of strong AF2.

Le Zhang, Yong Gu, Xin Zhao et al.

ATARI is a suite of video games used by reinforcement learning (RL) researchers to test the effectiveness of the learning algorithm. Receiving only the raw pixels and the game score, the agent learns to develop sophisticated strategies, even to the comparable level of a professional human games tester. Ideally, we also want an agent requiring very few interactions with the environment. Previous competitive model-free algorithms for the task use the valued-based Rainbow algorithm without any policy head. In this paper, we change it by proposing a practical discrete variant of the soft actor-critic (SAC) algorithm. The new variant enables off-policy learning using policy heads for discrete domains. By incorporating it into the advanced Rainbow variant, i.e., the ``bigger, better, faster'' (BBF), the resulting SAC-BBF improves the previous state-of-the-art interquartile mean (IQM) from 1.045 to 1.088, and it achieves these results using only replay ratio (RR) 2. By using lower RR 2, the training time of SAC-BBF is strictly one-third of the time required for BBF to achieve an IQM of 1.045 using RR 8. As a value of IQM greater than one indicates super-human performance, SAC-BBF is also the only model-free algorithm with a super-human level using only RR 2. The code is publicly available on GitHub at https://github.com/lezhang-thu/bigger-better-faster-SAC.

Cheng Lei, Jie Fan, Xinran Li et al.

Camouflaged Object Segmentation (COS) faces significant challenges due to the scarcity of annotated data, where meticulous pixel-level annotation is both labor-intensive and costly, primarily due to the intricate object-background boundaries. Addressing the core question, "Can COS be effectively achieved in a zero-shot manner without manual annotations for any camouflaged object?" we affirmatively respond and introduce a robust zero-shot COS framework. This framework leverages the inherent local pattern bias of COS and employs a broad semantic feature space derived from salient object segmentation (SOS) for efficient zero-shot transfer. We incorporate an Masked Image Modeling (MIM) based image encoder optimized for Parameter-Efficient Fine-Tuning (PEFT), a Multimodal Large Language Model (M-LLM), and a Multi-scale Fine-grained Alignment (MFA) mechanism. The MIM pre-trained image encoder focuses on capturing essential low-level features, while the M-LLM generates caption embeddings processed alongside these visual cues. These embeddings are precisely aligned using MFA, enabling our framework to accurately interpret and navigate complex semantic contexts. To optimize operational efficiency, we introduce a learnable codebook that represents the M-LLM during inference, significantly reducing computational overhead. Our framework demonstrates its versatility and efficacy through rigorous experimentation, achieving state-of-the-art performance in zero-shot COS with $F_β^w$ scores of 72.9\% on CAMO and 71.7\% on COD10K. By removing the M-LLM during inference, we achieve an inference speed comparable to that of traditional end-to-end models, reaching 18.1 FPS. Code: https://github.com/R-LEI360725/ZSCOS-CaMF

Xinqing Li, Xin He, Le Zhang et al.

Embodied AI requires agents that perceive, act, and anticipate how actions reshape future world states. World models serve as internal simulators that capture environment dynamics, enabling forward and counterfactual rollouts to support perception, prediction, and decision making. This survey presents a unified framework for world models in embodied AI. Specifically, we formalize the problem setting and learning objectives, and propose a three-axis taxonomy encompassing: (1) Functionality, Decision-Coupled vs. General-Purpose; (2) Temporal Modeling, Sequential Simulation and Inference vs. Global Difference Prediction; (3) Spatial Representation, Global Latent Vector, Token Feature Sequence, Spatial Latent Grid, and Decomposed Rendering Representation. We systematize data resources and metrics across robotics, autonomous driving, and general video settings, covering pixel prediction quality, state-level understanding, and task performance. Furthermore, we offer a quantitative comparison of state-of-the-art models and distill key open challenges, including the scarcity of unified datasets and the need for evaluation metrics that assess physical consistency over pixel fidelity, the trade-off between model performance and the computational efficiency required for real-time control, and the core modeling difficulty of achieving long-horizon temporal consistency while mitigating error accumulation. Finally, we maintain a curated bibliography at https://github.com/Li-Zn-H/AwesomeWorldModels.

Zekun Jiang, Wei Dai, Qu Wei et al.

Multi-channel EEG signals are commonly used for the diagnosis and assessment of diseases such as epilepsy. Currently, various EEG diagnostic algorithms based on deep learning have been developed. However, most research efforts focus solely on diagnosing and classifying current signal data but do not consider the prediction of future trends for early warning. Additionally, since multi-channel EEG can be essentially regarded as the spatio-temporal signal data received by detectors at different locations in the brain, how to construct spatio-temporal information representations of EEG signals to facilitate future trend prediction for multi-channel EEG becomes an important problem. This study proposes a multi-signal prediction algorithm based on generative diffusion models (EEG-DIF), which transforms the multi-signal forecasting task into an image completion task, allowing for comprehensive representation and learning of the spatio-temporal correlations and future developmental patterns of multi-channel EEG signals. Here, we employ a publicly available epilepsy EEG dataset to construct and validate the EEG-DIF. The results demonstrate that our method can accurately predict future trends for multi-channel EEG signals simultaneously. Furthermore, the early warning accuracy for epilepsy seizures based on the generated EEG data reaches 0.89. In general, EEG-DIF provides a novel approach for characterizing multi-channel EEG signals and an innovative early warning algorithm for epilepsy seizures, aiding in optimizing and enhancing the clinical diagnosis process. The code is available at https://github.com/JZK00/EEG-DIF.

Rahman Attar, Marco Pereanez, Ali Gooya et al.

The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a pipeline should comprise quality monitoring of the input images, segmentation of the cardiac structures, assessment of the segmentation quality, and parsing of cardiac functional indexes. We present a fully automatic, high throughput image parsing workflow for the analysis of cardiac MR images, and test its performance on the UK Biobank (UKB) cardiac dataset. The proposed pipeline is capable of performing end-to-end image processing including: data organisation, image quality assessment, shape model initialisation, segmentation, segmentation quality assessment, and functional parameter computation; all without any user interaction. To the best of our knowledge,this is the first paper tackling the fully automatic 3D analysis of the UKB population study, providing reference ranges for all key cardiovascular functional indexes, from both left and right ventricles of the heart. We tested our workflow on a reference cohort of 800 healthy subjects for which manual delineations, and reference functional indexes exist. Our results show statistically significant agreement between the manually obtained reference indexes, and those automatically computed using our framework.

Binghui Wang, Jinyuan Jia, Le Zhang et al.

Sybil detection in social networks is a basic security research problem. Structure-based methods have been shown to be promising at detecting Sybils. Existing structure-based methods can be classified into Random Walk (RW)-based methods and Loop Belief Propagation (LBP)-based methods. RW-based methods cannot leverage labeled Sybils and labeled benign users simultaneously, which limits their detection accuracy, and/or they are not robust to noisy labels. LBP-based methods are not scalable and cannot guarantee convergence. In this work, we propose SybilSCAR, a novel structure-based method to detect Sybils in social networks. SybilSCAR is Scalable, Convergent, Accurate, and Robust to label noise. We first propose a framework to unify RW-based and LBP-based methods. Under our framework, these methods can be viewed as iteratively applying a (different) local rule to every user, which propagates label information among a social graph. Second, we design a new local rule, which SybilSCAR iteratively applies to every user to detect Sybils. We compare SybilSCAR with state-of-the-art RW-based and LBP-based methods theoretically and empirically. Theoretically, we show that, with proper parameter settings, SybilSCAR has a tighter asymptotical bound on the number of Sybils that are falsely accepted into a social network than existing structure-based methods. Empirically, we perform evaluation using both social networks with synthesized Sybils and a large-scale Twitter dataset (41.7M nodes and 1.2B edges) with real Sybils. Our results show that 1) SybilSCAR is substantially more accurate and more robust to label noise than state-of-the-art RW-based methods; 2) SybilSCAR is more accurate and one order of magnitude more scalable than state-of-the-art LBP-based methods.