Ming Li

Yichao Zhang, Ningyuan Deng, Xinyuan Song et al.

After AlphaFold won the Nobel Prize, protein prediction with deep learning once again became a hot topic. We comprehensively explore advanced deep learning methods applied to protein structure prediction and design. It begins by examining recent innovations in prediction architectures, with detailed discussions on improvements such as diffusion based frameworks and novel pairwise attention modules. The text analyses key components including structure generation, evaluation metrics, multiple sequence alignment processing, and network architecture, thereby illustrating the current state of the art in computational protein modelling. Subsequent chapters focus on practical applications, presenting case studies that range from individual protein predictions to complex biomolecular interactions. Strategies for enhancing prediction accuracy and integrating deep learning techniques with experimental validation are thoroughly explored. The later sections review the industry landscape of protein design, highlighting the transformative role of artificial intelligence in biotechnology and discussing emerging market trends and future challenges. Supplementary appendices provide essential resources such as databases and open source tools, making this volume a valuable reference for researchers and students.

Yufan Liu, Jinyang An, Wanqian Zhang et al.

The remarkable development of text-to-image generation models has raised notable security concerns, such as the infringement of portrait rights and the generation of inappropriate content. Concept erasure has been proposed to remove the model's knowledge about protected and inappropriate concepts. Although many methods have tried to balance the efficacy (erasing target concepts) and specificity (retaining irrelevant concepts), they can still generate abundant erasure concepts under the steering of semantically related inputs. In this work, we propose RealEra to address this "concept residue" issue. Specifically, we first introduce the mechanism of neighbor-concept mining, digging out the associated concepts by adding random perturbation into the embedding of erasure concept, thus expanding the erasing range and eliminating the generations even through associated concept inputs. Furthermore, to mitigate the negative impact on the generation of irrelevant concepts caused by the expansion of erasure scope, RealEra preserves the specificity through the beyond-concept regularization. This makes irrelevant concepts maintain their corresponding spatial position, thereby preserving their normal generation performance. We also employ the closed-form solution to optimize weights of U-Net for the cross-attention alignment, as well as the prediction noise alignment with the LoRA module. Extensive experiments on multiple benchmarks demonstrate that RealEra outperforms previous concept erasing methods in terms of superior erasing efficacy, specificity, and generality. More details are available on our project page https://realerasing.github.io/RealEra/ .

Weiche Hsieh, Ziqian Bi, Junyu Liu et al.

Digital Signal Processing (DSP) and Digital Image Processing (DIP) with Machine Learning (ML) and Deep Learning (DL) are popular research areas in Computer Vision and related fields. We highlight transformative applications in image enhancement, filtering techniques, and pattern recognition. By integrating frameworks like the Discrete Fourier Transform (DFT), Z-Transform, and Fourier Transform methods, we enable robust data manipulation and feature extraction essential for AI-driven tasks. Using Python, we implement algorithms that optimize real-time data processing, forming a foundation for scalable, high-performance solutions in computer vision. This work illustrates the potential of ML and DL to advance DSP and DIP methodologies, contributing to artificial intelligence, automated feature extraction, and applications across diverse domains.

Chenyi Wang, Ruoyu Song, Raymond Muller et al.

Cooperative perception (CP) enhances situational awareness of connected and autonomous vehicles by exchanging and combining messages from multiple agents. While prior work has explored adversarial integrity attacks that degrade perceptual accuracy, little is known about CP's robustness against attacks on timeliness (or availability), a safety-critical requirement for autonomous driving. In this paper, we present CP-FREEZER, the first latency attack that maximizes the computation delay of CP algorithms by injecting adversarial perturbation via V2V messages. Our attack resolves several unique challenges, including the non-differentiability of point cloud preprocessing, asynchronous knowledge of the victim's input due to transmission delays, and uses a novel loss function that effectively maximizes the execution time of the CP pipeline. Extensive experiments show that CP-FREEZER increases end-to-end CP latency by over $90\times$, pushing per-frame processing time beyond 3 seconds with a 100% success rate on our real-world vehicle testbed. Our findings reveal a critical threat to the availability of CP systems, highlighting the urgent need for robust defenses.

Runze Cheng, Xihang Qiu, Ming Li et al.

Multimodal MRI provides critical complementary information for accurate brain tumor segmentation. However, conventional methods struggle when certain modalities are missing due to issues such as image quality, protocol inconsistencies, patient allergies, or financial constraints. To address this, we propose a robust single-modality parallel processing framework that achieves high segmentation accuracy even with incomplete modalities. Leveraging Holder divergence and mutual information, our model maintains modality-specific features while dynamically adjusting network parameters based on the available inputs. By using these divergence- and information-based loss functions, the framework effectively quantifies discrepancies between predictions and ground-truth labels, resulting in consistently accurate segmentation. Extensive evaluations on the BraTS 2018 and BraTS 2020 datasets demonstrate superior performance over existing methods in handling missing modalities.

Bo Jiang, Mohamed Seif, Ravi Tandon et al.

In this paper, we consider the problem of answering count queries for genomic data subject to perfect privacy constraints. Count queries are often used in applications that collect aggregate (population-wide) information from biomedical Databases (DBs) for analysis, such as Genome-wide association studies. Our goal is to design mechanisms for answering count queries of the following form: \textit{How many users in the database have a specific set of genotypes at certain locations in their genome?} At the same time, we aim to achieve perfect privacy (zero information leakage) of the sensitive genotypes at a pre-specified set of secret locations. The sensitive genotypes could indicate rare diseases and/or other health traits one may want to keep private. We present both local and central count-query mechanisms for the above problem that achieves perfect information-theoretic privacy for sensitive genotypes while minimizing the expected absolute error (or per-user error probability, depending on the setting) of the query answer. We also derived a lower bound of the per-user probability of error for an arbitrary query-answering mechanism that satisfies perfect privacy. We show that our mechanisms achieve error close to the lower bound, and match the lower bound for some special cases. We numerically show that the performance of each mechanism depends on the data prior distribution, the intersection between the queried and sensitive genotypes, and the strength of the correlation in the genomic data sequence.

Xiaolan Gu, Ming Li, Li Xiong

Federated Learning (FL) allows multiple participating clients to train machine learning models collaboratively by keeping their datasets local and only exchanging model updates. Existing FL protocol designs have been shown to be vulnerable to attacks that aim to compromise data privacy and/or model robustness. Recently proposed defenses focused on ensuring either privacy or robustness, but not both. In this paper, we develop a framework called PRECAD, which simultaneously achieves differential privacy (DP) and enhances robustness against model poisoning attacks with the help of cryptography. Using secure multi-party computation (MPC) techniques (e.g., secret sharing), noise is added to the model updates by the honest-but-curious server(s) (instead of each client) without revealing clients' inputs, which achieves the benefit of centralized DP in terms of providing a better privacy-utility tradeoff than local DP based solutions. Meanwhile, a crypto-aided secure validation protocol is designed to verify that the contribution of model update from each client is bounded without leaking privacy. We show analytically that the noise added to ensure DP also provides enhanced robustness against malicious model submissions. We experimentally demonstrate that our PRECAD framework achieves higher privacy-utility tradeoff and enhances robustness for the trained models.

Yao Zheng, Shekh Md Mahmudul Islam, Yanjun Pan et al.

The increasingly sophisticated at-home screening systems for obstructive sleep apnea (OSA), integrated with both contactless and contact-based sensing modalities, bring convenience and reliability to remote chronic disease management. However, the device pairing processes between system components are vulnerable to wireless exploitation from a non-compliant user wishing to manipulate the test results. This work presents SIENNA, an insider-resistant context-based pairing protocol. SIENNA leverages JADE-ICA to uniquely identify a user's respiration pattern within a multi-person environment and fuzzy commitment for automatic device pairing, while using friendly jamming technique to prevents an insider with knowledge of respiration patterns from acquiring the pairing key. Our analysis and test results show that SIENNA can achieve reliable (> 90% success rate) device pairing under a noisy environment and is robust against the attacker with full knowledge of the context information.

Mohamed Seif, Ravi Tandon, Ming Li

In this paper, we study the problem of federated learning (FL) over a wireless channel, modeled by a Gaussian multiple access channel (MAC), subject to local differential privacy (LDP) constraints. We show that the superposition nature of the wireless channel provides a dual benefit of bandwidth efficient gradient aggregation, in conjunction with strong LDP guarantees for the users. We propose a private wireless gradient aggregation scheme, which shows that when aggregating gradients from $K$ users, the privacy leakage per user scales as $\mathcal{O}\big(\frac{1}{\sqrt{K}} \big)$ compared to orthogonal transmission in which the privacy leakage scales as a constant. We also present analysis for the convergence rate of the proposed private FL aggregation algorithm and study the tradeoffs between wireless resources, convergence, and privacy.

Yanjun Pan, Alon Efrat, Ming Li et al.

Due to increasing concerns of data privacy, databases are being encrypted before they are stored on an untrusted server. To enable search operations on the encrypted data, searchable encryption techniques have been proposed. Representative schemes use order-preserving encryption (OPE) for supporting efficient Boolean queries on encrypted databases. Yet, recent works showed the possibility of inferring plaintext data from OPE-encrypted databases, merely using the order-preserving constraints, or combined with an auxiliary plaintext dataset with similar frequency distribution. So far, the effectiveness of such attacks is limited to single-dimensional dense data (most values from the domain are encrypted), but it remains challenging to achieve it on high-dimensional datasets (e.g., spatial data) which are often sparse in nature. In this paper, for the first time, we study data inference attacks on multi-dimensional encrypted databases (with 2-D as a special case). We formulate it as a 2-D order-preserving matching problem and explore both unweighted and weighted cases, where the former maximizes the number of points matched using only order information and the latter further considers points with similar frequencies. We prove that the problem is NP-hard, and then propose a greedy algorithm, along with a polynomial-time algorithm with approximation guarantees. Experimental results on synthetic and real-world datasets show that the data recovery rate is significantly enhanced compared with the previous 1-D matching algorithm.

Bo Jiang, Ming Li, Ravi Tandon

In this paper, we study local information privacy (LIP), and design LIP based mechanisms for statistical aggregation while protecting users' privacy without relying on a trusted third party. The notion of context-awareness is incorporated in LIP, which can be viewed as explicit modeling of the adversary's background knowledge. It enables the design of privacy-preserving mechanisms leveraging the prior distribution, which can potentially achieve a better utility-privacy tradeoff than context-free notions such as Local Differential Privacy (LDP). We present an optimization framework to minimize the mean square error in the data aggregation while protecting the privacy of each individual user's input data or a correlated latent variable while satisfying LIP constraints. Then, we study two different types of applications: (weighted) summation and histogram estimation and derive the optimal context-aware data perturbation parameters for each case, based on randomized response type of mechanism. We further compare the utility-privacy tradeoff between LIP and LDP and theoretically explain why the incorporation of prior knowledge enlarges feasible regions of the perturbation parameters, which thereby leads to higher utility. We also extend the LIP-based privacy mechanisms to the more general case when exact prior knowledge is not available. Finally, we validate our analysis by simulations using both synthetic and real-world data. Results show that our LIP-based privacy mechanism provides better utility-privacy tradeoffs than LDP, and the advantage of LIP is even more significant when the prior distribution is more skewed.

Xiaolan Gu, Ming Li, Yueqiang Cheng et al.

Data collection under local differential privacy (LDP) has been mostly studied for homogeneous data. Real-world applications often involve a mixture of different data types such as key-value pairs, where the frequency of keys and mean of values under each key must be estimated simultaneously. For key-value data collection with LDP, it is challenging to achieve a good utility-privacy tradeoff since the data contains two dimensions and a user may possess multiple key-value pairs. There is also an inherent correlation between key and values which if not harnessed, will lead to poor utility. In this paper, we propose a locally differentially private key-value data collection framework that utilizes correlated perturbations to enhance utility. We instantiate our framework by two protocols PCKV-UE (based on Unary Encoding) and PCKV-GRR (based on Generalized Randomized Response), where we design an advanced Padding-and-Sampling mechanism and an improved mean estimator which is non-interactive. Due to our correlated key and value perturbation mechanisms, the composed privacy budget is shown to be less than that of independent perturbation of key and value, which enables us to further optimize the perturbation parameters via budget allocation. Experimental results on both synthetic and real-world datasets show that our proposed protocols achieve better utility for both frequency and mean estimations under the same LDP guarantees than state-of-the-art mechanisms.

Xiaolan Gu, Ming Li, Li Xiong et al.

Local Differential Privacy (LDP) provides provable privacy protection for data collection without the assumption of the trusted data server. In the real-world scenario, different data have different privacy requirements due to the distinct sensitivity levels. However, LDP provides the same protection for all data. In this paper, we tackle the challenge of providing input-discriminative protection to reflect the distinct privacy requirements of different inputs. We first present the Input-Discriminative LDP (ID-LDP) privacy notion and focus on a specific version termed MinID-LDP, which is shown to be a fine-grained version of LDP. Then, we focus on the application of frequency estimation and develop the IDUE mechanism based on Unary Encoding for single-item input and the extended mechanism IDUE-PS (with Padding-and-Sampling protocol) for item-set input. The results on both synthetic and real-world datasets validate the correctness of our theoretical analysis and show that the proposed mechanisms satisfying MinID-LDP have better utility than the state-of-the-art mechanisms satisfying LDP due to the input-discriminative protection.

Bo Jiang, Ming Li, Ravi Tandon

In this paper, localized information privacy (LIP) is proposed, as a new privacy definition, which allows statistical aggregation while protecting users' privacy without relying on a trusted third party. The notion of context-awareness is incorporated in LIP by the introduction of priors, which enables the design of privacy-preserving data aggregation with knowledge of priors. We show that LIP relaxes the Localized Differential Privacy (LDP) notion by explicitly modeling the adversary's knowledge. However, it is stricter than $2ε$-LDP and $ε$-mutual information privacy. The incorporation of local priors allows LIP to achieve higher utility compared to other approaches. We then present an optimization framework for privacy-preserving data aggregation, with the goal of minimizing the expected squared error while satisfying the LIP privacy constraints. Utility-privacy tradeoffs are obtained under several models in closed-form. We then validate our analysis by {numerical analysis} using both synthetic and real-world data. Results show that our LIP mechanism provides better utility-privacy tradeoffs than LDP and when the prior is not uniformly distributed, the advantage of LIP is even more significant.