Ming Li

Ming Li, Ariunaa Enkhtur, Fei Cheng et al.

This scoping review explores the ethical challenges of using ChatGPT in higher education. By reviewing recent academic articles in English, Chinese, and Japanese, we aimed to provide a deep dive review and identify gaps in the literature. Drawing on Arksey and O'Malley's (2005) scoping review framework, we defined search terms and identified relevant publications from four databases in the three target languages. The research results showed that the majority of the papers were discussion papers, but there was some early empirical work. The ethical issues highlighted in these works mainly concern academic integrity, assessment issues, and data protection. Given the rapid deployment of generative artificial intelligence, it is imperative for educators to conduct more empirical studies to develop sound ethical policies for its use.

Tianyang Wang, Ming Liu, Benji Peng et al.

Clinical trials are an indispensable part of the drug development process, bridging the gap between basic research and clinical application. During the development of new drugs, clinical trials are used not only to evaluate the safety and efficacy of the drug but also to explore its dosage, treatment regimens, and potential side effects. This review discusses the various stages of clinical trials, including Phase I (safety assessment), Phase II (preliminary efficacy evaluation), Phase III (large-scale validation), and Phase IV (post-marketing surveillance), highlighting the characteristics of each phase and their interrelationships. Additionally, the paper addresses the major challenges encountered in clinical trials, such as ethical issues, subject recruitment difficulties, diversity and representativeness concerns, and proposes strategies for overcoming these challenges. With the advancement of technology, innovative technologies such as artificial intelligence, big data, and digitalization are gradually transforming clinical trial design and implementation, improving trial efficiency and data quality. The article also looks forward to the future of clinical trials, particularly the impact of emerging therapies such as gene therapy and immunotherapy on trial design, as well as the importance of regulatory reforms and global collaboration. In conclusion, the core role of clinical trials in drug development will continue to drive the progress of innovative drug development and clinical treatment.