Hao Chen

Zhixuan Chen, Junlin Hou, Liqi Lin et al.

Pathology image segmentation is crucial in computational pathology for analyzing histological features relevant to cancer diagnosis and prognosis. However, current methods face major challenges in clinical applications due to limited annotated data and restricted category definitions. To address these limitations, we propose PathSegmentor, the first text-prompted segmentation foundation model designed specifically for pathology images. We also introduce PathSeg, the largest and most comprehensive dataset for pathology segmentation, built from 21 public sources and containing 275k image-mask-label triples across 160 diverse categories. With PathSegmentor, users can perform semantic segmentation using natural language prompts, eliminating the need for laborious spatial inputs such as points or boxes. Extensive experiments demonstrate that PathSegmentor outperforms specialized models with higher accuracy and broader applicability, while maintaining a compact architecture. It significantly surpasses existing spatial- and text-prompted models by 0.145 and 0.429 in overall Dice scores, respectively, showing strong robustness in segmenting complex structures and generalizing to external datasets. Moreover, PathSegmentor's outputs enhance the interpretability of diagnostic models through feature importance estimation and imaging biomarker discovery, offering pathologists evidence-based support for clinical decision-making. This work advances the development of explainable AI in precision oncology.

Hao Chen, Maria Vasardani, Stephan Winter

Everyday place descriptions often contain place names of fine-grained features, such as buildings or businesses, that are more difficult to disambiguate than names referring to larger places, for example cities or natural geographic features. Fine-grained places are often significantly more frequent and more similar to each other, and disambiguation heuristics developed for larger places, such as those based on population or containment relationships, are often not applicable in these cases. In this research, we address the disambiguation of fine-grained place names from everyday place descriptions. For this purpose, we evaluate the performance of different existing clustering-based approaches, since clustering approaches require no more knowledge other than the locations of ambiguous place names. We consider not only approaches developed specifically for place name disambiguation, but also clustering algorithms developed for general data mining that could potentially be leveraged. We compare these methods with a novel algorithm, and show that the novel algorithm outperforms the other algorithms in terms of disambiguation precision and distance error over several tested datasets.

Hao Chen, Maria Vasardani, Stephan Winter

Natural language place descriptions in everyday communication provide a rich source of spatial knowledge about places. An important step to utilize such knowledge in information systems is geo-referencing all the places referred to in these descriptions. Current techniques for geo-referencing places from text documents are using place name recognition and disambiguation; however, place descriptions often contain place references that are not known by gazetteers, or that are expressed in other, more flexible ways. Hence, the approach for geo-referencing presented in this paper starts from a place graph that contains the place references as well as spatial relationships extracted from place descriptions. Spatial relationships are used to constrain the locations of places and allow the later best-matching process for geo-referencing. The novel geo-referencing process results in higher precision and recall compared to state-of-art toponym resolution approaches on several tested place description datasets.