Yang Liu

Yan Wang, Shaoqi Yan, Yang Liu et al.

Facial expression recognition (FER) aims to analyze emotional states from static images and dynamic sequences, which is pivotal in enhancing anthropomorphic communication among humans, robots, and digital avatars by leveraging AI technologies. As the FER field evolves from controlled laboratory environments to more complex in-the-wild scenarios, advanced methods have been rapidly developed and new challenges and apporaches are encounted, which are not well addressed in existing reviews of FER. This paper offers a comprehensive survey of both image-based static FER (SFER) and video-based dynamic FER (DFER) methods, analyzing from model-oriented development to challenge-focused categorization. We begin with a critical comparison of recent reviews, an introduction to common datasets and evaluation criteria, and an in-depth workflow on FER to establish a robust research foundation. We then systematically review representative approaches addressing eight main challenges in SFER (such as expression disturbance, uncertainties, compound emotions, and cross-domain inconsistency) as well as seven main challenges in DFER (such as key frame sampling, expression intensity variations, and cross-modal alignment). Additionally, we analyze recent advancements, benchmark performances, major applications, and ethical considerations. Finally, we propose five promising future directions and development trends to guide ongoing research. The project page for this paper can be found at https://github.com/wangyanckxx/SurveyFER.

Rubin Zhao, Yang Liu, Shiqi Zhang et al.

Neurons, with their elongated, tree-like dendritic and axonal structures, enable efficient signal integration and long-range communication across brain regions. By reconstructing individual neurons' morphology, we can gain valuable insights into brain connectivity, revealing the structure basis of cognition, movement, and perception. Despite the accumulation of extensive 3D microscopic imaging data, progress has been considerably hindered by the absence of automated tools to streamline this process. Here we introduce NeuroFly, a validated framework for large-scale automatic single neuron reconstruction. This framework breaks down the process into three distinct stages: segmentation, connection, and proofreading. In the segmentation stage, we perform automatic segmentation followed by skeletonization to generate over-segmented neuronal fragments without branches. During the connection stage, we use a 3D image-based path following approach to extend each fragment and connect it with other fragments of the same neuron. Finally, human annotators are required only to proofread the few unresolved positions. The first two stages of our process are clearly defined computer vision problems, and we have trained robust baseline models to solve them. We validated NeuroFly's efficiency using in-house datasets that include a variety of challenging scenarios, such as dense arborizations, weak axons, images with contamination. We will release the datasets along with a suite of visualization and annotation tools for better reproducibility. Our goal is to foster collaboration among researchers to address the neuron reconstruction challenge, ultimately accelerating advancements in neuroscience research. The dataset and code are available at https://github.com/beanli161514/neurofly

Ryan K. Tan, Yang Liu, Lei Xie

Many multi-genic systemic diseases such as neurological disorders, inflammatory diseases, and the majority of cancers do not have effective treatments yet. Reinforcement learning powered systems pharmacology is a potentially effective approach to design personalized therapies for untreatable complex diseases. In this survey, state-of-the-art reinforcement learning methods and their latest applications to drug design are reviewed. The challenges on harnessing reinforcement learning for systems pharmacology and personalized medicine are discussed. Potential solutions to overcome the challenges are proposed. In spite of successful application of advanced reinforcement learning techniques to target-based drug discovery, new reinforcement learning strategies are needed to address systems pharmacology-oriented personalized de novo drug design.