Ruochen Gao

Ben Wang, Xiaogang Li, Ruochen Gao et al.

Current multimodal models handle static image recognition well, but intuitive physical reasoning remains a weakness. Predicting how objects will move and interact from a single image is still difficult for these systems. We present BilliardPhys-Bench, a benchmark for physical reasoning in synthetic billiards environments. Its procedural engine generates randomized scenarios with friction and elastic collisions. The benchmark tests three abilities: (1) predicting ball-to-ball collisions, (2) reasoning about wall bounces, and (3) estimating final ball positions after motion stops. We evaluate recent MLLMs from the GPT, Claude, Gemini, and Qwen families. Performance drops as simulation time increases and scene geometry grows more complex. We also observe a consistent failure mode we call "stasis bias": when the correct physical outcome is harder to infer, models tend to predict no interaction. These findings show where current MLLMs break down on visual dynamics and point toward the need for better physical inductive biases in multimodal architectures.

Jun Ma, Feifei Li, Sumin Kim et al.

Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical practice. In this work, we organized the first international competition dedicated to promptable medical image segmentation, featuring a large-scale dataset spanning nine common imaging modalities from over 20 different institutions. The top teams developed lightweight segmentation foundation models and implemented an efficient inference pipeline that substantially reduced computational requirements while maintaining state-of-the-art segmentation accuracy. Moreover, the post-challenge phase advanced the algorithms through the design of performance booster and reproducibility tasks, resulting in improved algorithms and validated reproducibility of the winning solution. Furthermore, the best-performing algorithms have been incorporated into the open-source software with a user-friendly interface to facilitate clinical adoption. The data and code are publicly available to foster the further development of medical image segmentation foundation models and pave the way for impactful real-world applications.

Ruochen Gao, Donghang Lyu, Marius Staring

Medical imaging is essential for the diagnosis and treatment of diseases, with medical image segmentation as a subtask receiving high attention. However, automatic medical image segmentation models are typically task-specific and struggle to handle multiple scenarios, such as different imaging modalities and regions of interest. With the introduction of the Segment Anything Model (SAM), training a universal model for various clinical scenarios has become feasible. Recently, several Medical SAM (MedSAM) methods have been proposed, but these models often rely on heavy image encoders to achieve high performance, which may not be practical for real-world applications due to their high computational demands and slow inference speed. To address this issue, a lightweight version of the MedSAM (LiteMedSAM) can provide a viable solution, achieving high performance while requiring fewer resources and less time. In this work, we introduce Swin-LiteMedSAM, a new variant of LiteMedSAM. This model integrates the tiny Swin Transformer as the image encoder, incorporates multiple types of prompts, including box-based points and scribble generated from a given bounding box, and establishes skip connections between the image encoder and the mask decoder. In the \textit{Segment Anything in Medical Images on Laptop} challenge (CVPR 2024), our approach strikes a good balance between segmentation performance and speed, demonstrating significantly improved overall results across multiple modalities compared to the LiteMedSAM baseline provided by the challenge organizers. Our proposed model achieved a DSC score of \textbf{0.8678} and an NSD score of \textbf{0.8844} on the validation set. On the final test set, it attained a DSC score of \textbf{0.8193} and an NSD score of \textbf{0.8461}, securing fourth place in the challenge.

Donghang Lyu, Ruochen Gao, Marius Staring

Medical image segmentation involves partitioning medical images into meaningful regions, with a focus on identifying anatomical structures and lesions. It has broad applications in healthcare, and deep learning methods have enabled significant advancements in automating this process. Recently, the introduction of the Segmentation Anything Model (SAM), the first foundation model for segmentation task, has prompted researchers to adapt it for the medical domain to improve performance across various tasks. However, SAM's large model size and high GPU requirements hinder its scalability and development in the medical domain. In this work, we propose MCP-MedSAM, a powerful and lightweight medical SAM model designed to be trainable on a single A100 GPU with 40GB of memory within one day while delivering superior segmentation performance. Recognizing the significant internal differences between modalities and the need for direct segmentation target information within bounding boxes, we introduce two kinds of prompts: the modality prompt and the content prompt. After passing through the prompt encoder, their embedding representations can further improve the segmentation performance by incorporating more relevant information without adding significant training overhead. Additionally, we adopt an effective modality-based data sampling strategy to address data imbalance between modalities, ensuring more balanced performance across all modalities. Our method was trained and evaluated using a large-scale challenge dataset, compared to top-ranking methods on the challenge leaderboard, MCP-MedSAM achieved superior performance while requiring only one day of training on a single GPU. The code is publicly available at \textcolor{blue}{https://github.com/dong845/MCP-MedSAM}.}

Ruochen Gao, Marius Staring, Frank Dankers

Purpose: Deep-learning-based three-dimensional (3D) dose prediction is widely used in automated radiotherapy workflows. However, most existing models are trained with voxel-wise regression losses, which are poorly aligned with clinical plan evaluation criteria based on dose-volume histogram (DVH) metrics. This study aims to develop a clinically guided loss formulation that directly optimizes clinically used DVH metrics while remaining computationally efficient for head and neck (H\&N) dose prediction. Methods: We propose a clinical DVH metric loss (CDM loss) that incorporates differentiable \textit{D-metrics} and surrogate \textit{V-metrics}, together with a lossless bit-mask region-of-interest (ROI) encoding to improve training efficiency. The method was evaluated on 174 H\&N patients using a temporal split (137 training, 37 testing). Results: Compared with MAE- and DVH-curve based losses, CDM loss substantially improved target coverage and satisfied all clinical constraints. Using a standard 3D U-Net, the PTV Score was reduced from 1.544 (MAE) to 0.491 (MAE + CDM), while OAR sparing remained comparable. Bit-mask encoding reduced training time by 83\% and lowered GPU memory usage. Conclusion: Directly optimizing clinically used DVH metrics enables 3D dose predictions that are better aligned with clinical treatment planning criteria than conventional voxel-wise or DVH-curve-based supervision. The proposed CDM loss, combined with efficient ROI bit-mask encoding, provides a practical and scalable framework for H\&N dose prediction.