Huan Zhang

Wenhao Huang, Haifan Gong, Huan Zhang et al.

CT-based bronchial tree analysis plays an important role in the computer-aided diagnosis for respiratory diseases, as it could provide structured information for clinicians. The basis of airway analysis is bronchial tree reconstruction, which consists of bronchus segmentation and classification. However, there remains a challenge for accurate bronchial analysis due to the individual variations and the severe class imbalance. In this paper, we propose a region and structure prior embedded framework named BronchusNet to achieve accurate segmentation and classification of bronchial regions in CT images. For bronchus segmentation, we propose an adaptive hard region-aware UNet that incorporates multi-level prior guidance of hard pixel-wise samples in the general Unet segmentation network to achieve better hierarchical feature learning. For the classification of bronchial branches, we propose a hybrid point-voxel graph learning module to fully exploit bronchial structure priors and to support simultaneous feature interactions across different branches. To facilitate the study of bronchial analysis, we contribute~\textbf{BRSC}: an open-access benchmark of \textbf{BR}onchus imaging analysis with high-quality pixel-wise \textbf{S}egmentation masks and the \textbf{C}lass of bronchial segments. Experimental results on BRSC show that our proposed method not only achieves the state-of-the-art performance for binary segmentation of bronchial region but also exceeds the best existing method on bronchial branches classification by 6.9\%.

Haifan Gong, Wenhao Huang, Huan Zhang et al.

Automatic segmentation of the bronchial tree from CT imaging is important, as it provides structural information for disease diagnosis. Despite the merits of previous automatic bronchus segmentation methods, they have paied less attention to the issue we term as \textit{Intensity Confusion}, wherein the intensity values of certain background voxels approach those of the foreground voxels within bronchi. Conversely, the intensity values of some foreground voxels are nearly identical to those of background voxels. This proximity in intensity values introduces significant challenges to neural network methodologies. To address the issue, we introduce a novel Intensity-Distance Guided loss function, which assigns adaptive weights to different image voxels for mining hard samples that cause the intensity confusion. The proposed loss estimates the voxel-level hardness of samples, on the basis of the following intensity and distance priors. We regard a voxel as a hard sample if it is in: (1) the background and has an intensity value close to the bronchus region; (2) the bronchus region and is of higher intensity than most voxels inside the bronchus; (3) the background region and at a short distance from the bronchus. Extensive experiments not only show the superiority of our method compared with the state-of-the-art methods, but also verify that tackling the intensity confusion issue helps to significantly improve bronchus segmentation. Project page: https://github.com/lhaof/ICM.

Rongzhao Zhang, Zhian Bai, Ruoying Yu et al.

When delineating lesions from medical images, a human expert can always keep in mind the anatomical structure behind the voxels. However, although high-quality (though not perfect) anatomical information can be retrieved from computed tomography (CT) scans with modern deep learning algorithms, it is still an open problem how these automatically generated organ masks can assist in addressing challenging lesion segmentation tasks, such as the segmentation of colorectal cancer (CRC). In this paper, we develop a novel Anatomy-Guided segmentation framework to exploit the auto-generated organ masks to aid CRC segmentation from CT, namely AG-CRC. First, we obtain multi-organ segmentation (MOS) masks with existing MOS models (e.g., TotalSegmentor) and further derive a more robust organ of interest (OOI) mask that may cover most of the colon-rectum and CRC voxels. Then, we propose an anatomy-guided training patch sampling strategy by optimizing a heuristic gain function that considers both the proximity of important regions (e.g., the tumor or organs of interest) and sample diversity. Third, we design a novel self-supervised learning scheme inspired by the topology of tubular organs like the colon to boost the model performance further. Finally, we employ a masked loss scheme to guide the model to focus solely on the essential learning region. We extensively evaluate the proposed method on two CRC segmentation datasets, where substantial performance improvement (5% to 9% in Dice) is achieved over current state-of-the-art medical image segmentation models, and the ablation studies further evidence the efficacy of every proposed component.

Han Wang, Haoyu Li, Brian Ko et al.

Leaderboards for LRMs have turned evaluation into a competition, incentivizing developers to optimize directly on benchmark suites. A shortcut to achieving higher rankings is to incorporate evaluation benchmarks into the training data, thereby yielding inflated performance, known as benchmark contamination. Surprisingly, our studies find that evading contamination detections for LRMs is alarmingly easy. We focus on the two scenarios where contamination may occur in practice: (I) when the base model evolves into LRM via SFT and RL, we find that contamination during SFT can be originally identified by contamination detection methods. Yet, even a brief GRPO training can markedly conceal contamination signals that most detection methods rely on. Further empirical experiments and theoretical analysis indicate that PPO style importance sampling and clipping objectives are the root cause of this detection concealment, indicating that a broad class of RL methods may inherently exhibit similar concealment capability; (II) when SFT contamination with CoT is applied to advanced LRMs as the final stage, most contamination detection methods perform near random guesses. Without exposure to non-members, contaminated LRMs would still have more confidence when responding to those unseen samples that share similar distributions to the training set, and thus, evade existing memorization-based detection methods. Together, our findings reveal the unique vulnerability of LRMs evaluations: Model developers could easily contaminate LRMs to achieve inflated leaderboards performance while leaving minimal traces of contamination, thereby strongly undermining the fairness of evaluation and threatening the integrity of public leaderboards. This underscores the urgent need for advanced contamination detection methods and trustworthy evaluation protocols tailored to LRMs.