Xiaoyu Wang

Rong Han, Xiaohong Liu, Tong Pan et al.

Accurately measuring protein-RNA binding affinity is crucial in many biological processes and drug design. Previous computational methods for protein-RNA binding affinity prediction rely on either sequence or structure features, unable to capture the binding mechanisms comprehensively. The recent emerging pre-trained language models trained on massive unsupervised sequences of protein and RNA have shown strong representation ability for various in-domain downstream tasks, including binding site prediction. However, applying different-domain language models collaboratively for complex-level tasks remains unexplored. In this paper, we propose CoPRA to bridge pre-trained language models from different biological domains via Complex structure for Protein-RNA binding Affinity prediction. We demonstrate for the first time that cross-biological modal language models can collaborate to improve binding affinity prediction. We propose a Co-Former to combine the cross-modal sequence and structure information and a bi-scope pre-training strategy for improving Co-Former's interaction understanding. Meanwhile, we build the largest protein-RNA binding affinity dataset PRA310 for performance evaluation. We also test our model on a public dataset for mutation effect prediction. CoPRA reaches state-of-the-art performance on all the datasets. We provide extensive analyses and verify that CoPRA can (1) accurately predict the protein-RNA binding affinity; (2) understand the binding affinity change caused by mutations; and (3) benefit from scaling data and model size.

Yushen Zuo, Qi Zheng, Mingyang Wu et al.

We present 4KAgent, a unified agentic super-resolution generalist system designed to universally upscale any image to 4K resolution (and even higher, if applied iteratively). Our system can transform images from extremely low resolutions with severe degradations, for example, highly distorted inputs at 256x256, into crystal-clear, photorealistic 4K outputs. 4KAgent comprises three core components: (1) Profiling, a module that customizes the 4KAgent pipeline based on bespoke use cases; (2) A Perception Agent, which leverages vision-language models alongside image quality assessment experts to analyze the input image and make a tailored restoration plan; and (3) A Restoration Agent, which executes the plan, following a recursive execution-reflection paradigm, guided by a quality-driven mixture-of-expert policy to select the optimal output for each step. Additionally, 4KAgent embeds a specialized face restoration pipeline, significantly enhancing facial details in portrait and selfie photos. We rigorously evaluate our 4KAgent across 11 distinct task categories encompassing a total of 26 diverse benchmarks, setting new state-of-the-art on a broad spectrum of imaging domains. Our evaluations cover natural images, portrait photos, AI-generated content, satellite imagery, fluorescence microscopy, and medical imaging like fundoscopy, ultrasound, and X-ray, demonstrating superior performance in terms of both perceptual (e.g., NIQE, MUSIQ) and fidelity (e.g., PSNR) metrics. By establishing a novel agentic paradigm for low-level vision tasks, we aim to catalyze broader interest and innovation within vision-centric autonomous agents across diverse research communities. We will release all the code, models, and results at: https://4kagent.github.io.

Zitong Xu, Huiyu Duan, Xiaoyu Wang et al.

With the rapid advancement of generative models, powerful image editing methods now enable diverse and highly realistic image manipulations that far surpass traditional deepfake techniques, posing new challenges for manipulation detection. Existing image manipulation detection and localization (IMDL) benchmarks suffer from limited content diversity, narrow generative-model coverage, and insufficient interpretability, which hinders the generalization and explanation capabilities of current manipulation detection methods. To address these limitations, we introduce \textbf{ManipBench}, a large-scale benchmark for image manipulation detection and localization focusing on AI-edited images. ManipBench contains over 450K manipulated images produced by 25 state-of-the-art image editing models across 12 manipulation categories, among which 100K images are further annotated with bounding boxes, judgment cues, and textual explanations to support interpretable detection. Building upon ManipBench, we propose \textbf{ManipShield}, an all-in-one model based on a Multimodal Large Language Model (MLLM) that leverages contrastive LoRA fine-tuning and task-specific decoders to achieve unified image manipulation detection, localization, and explanation. Extensive experiments on ManipBench and several public datasets demonstrate that ManipShield achieves state-of-the-art performance and exhibits strong generality to unseen manipulation models. Both ManipBench and ManipShield will be released upon publication.