Chen Li

Chen Li, Xiaoling Hu, Shahira Abousamra et al.

Generative models, such as GANs and diffusion models, have been used to augment training sets and boost performances in different tasks. We focus on generative models for cell detection instead, i.e., locating and classifying cells in given pathology images. One important information that has been largely overlooked is the spatial patterns of the cells. In this paper, we propose a spatial-pattern-guided generative model for cell layout generation. Specifically, a novel diffusion model guided by spatial features and generates realistic cell layouts has been proposed. We explore different density models as spatial features for the diffusion model. In downstream tasks, we show that the generated cell layouts can be used to guide the generation of high-quality pathology images. Augmenting with these images can significantly boost the performance of SOTA cell detection methods. The code is available at https://github.com/superlc1995/Diffusion-cell.

Meilong Xu, Saumya Gupta, Xiaoling Hu et al.

Accurately modeling multi-class cell topology is crucial in digital pathology, as it provides critical insights into tissue structure and pathology. The synthetic generation of cell topology enables realistic simulations of complex tissue environments, enhances downstream tasks by augmenting training data, aligns more closely with pathologists' domain knowledge, and offers new opportunities for controlling and generalizing the tumor microenvironment. In this paper, we propose a novel approach that integrates topological constraints into a diffusion model to improve the generation of realistic, contextually accurate cell topologies. Our method refines the simulation of cell distributions and interactions, increasing the precision and interpretability of results in downstream tasks such as cell detection and classification. To assess the topological fidelity of generated layouts, we introduce a new metric, Topological Frechet Distance (TopoFD), which overcomes the limitations of traditional metrics like FID in evaluating topological structure. Experimental results demonstrate the effectiveness of our approach in generating multi-class cell layouts that capture intricate topological relationships. Code is available at https://github.com/Melon-Xu/TopoCellGen.

Jinnan Chen, Chen Li, Gim Hee Lee

We introduce DiHuR, a novel Diffusion-guided model for generalizable Human 3D Reconstruction and view synthesis from sparse, minimally overlapping images. While existing generalizable human radiance fields excel at novel view synthesis, they often struggle with comprehensive 3D reconstruction. Similarly, directly optimizing implicit Signed Distance Function (SDF) fields from sparse-view images typically yields poor results due to limited overlap. To enhance 3D reconstruction quality, we propose using learnable tokens associated with SMPL vertices to aggregate sparse view features and then to guide SDF prediction. These tokens learn a generalizable prior across different identities in training datasets, leveraging the consistent projection of SMPL vertices onto similar semantic areas across various human identities. This consistency enables effective knowledge transfer to unseen identities during inference. Recognizing SMPL's limitations in capturing clothing details, we incorporate a diffusion model as an additional prior to fill in missing information, particularly for complex clothing geometries. Our method integrates two key priors in a coherent manner: the prior from generalizable feed-forward models and the 2D diffusion prior, and it requires only multi-view image training, without 3D supervision. DiHuR demonstrates superior performance in both within-dataset and cross-dataset generalization settings, as validated on THuman, ZJU-MoCap, and HuMMan datasets compared to existing methods.