Weihua Zhang

Haoshen Wang, Lei Chen, Wei-Hua Zhang et al.

Cone beam computed tomography (CBCT)-guided puncture has become an established approach for diagnosing and treating early- to mid-stage thoracic tumours, yet the associated radiation exposure substantially elevates the risk of secondary malignancies. Although multiple low-dose CBCT strategies have been introduced, none have undergone validation using large-scale multicenter retrospective datasets, and prospective clinical evaluation remains lacking. Here, we propose DeepPriorCBCT - a three-stage deep learning framework that achieves diagnostic-grade reconstruction using only one-sixth of the conventional radiation dose. 4102 patients with 8675 CBCT scans from 12 centers were included to develop and validate DeepPriorCBCT. Additionally, a prospective cross-over trial (Registry number: NCT07035977) which recruited 138 patients scheduled for percutaneous thoracic puncture was conducted to assess the model's clinical applicability. Assessment by 11 physicians confirmed that reconstructed images were indistinguishable from original scans. Moreover, diagnostic performance and overall image quality were comparable to those generated by standard reconstruction algorithms. In the prospective trial, five radiologists reported no significant differences in image quality or lesion assessment between DeepPriorCBCT and the clinical standard (all P>0.05). Likewise, 25 interventionalists expressed no preference between model-based and full-sampling images for surgical guidance (Kappa<0.2). Radiation exposure with DeepPriorCBCT was reduced to approximately one-sixth of that with the conventional approach, and collectively, the findings confirm that it enables high-quality CBCT reconstruction under sparse sampling conditions while markedly decreasing intraoperative radiation risk.

Weihua Zhang, Chengze Jiang, Jie Gui et al.

Recent studies have revealed that hyperspectral classification models based on deep learning are highly vulnerable to adversarial attacks, which pose significant security risks. Although several approaches have attempted to enhance adversarial robustness by modifying network architectures, these methods often rely on customized designs that limit scalability and fail to defend effectively against strong attacks. To address these challenges, we introduce adversarial training to the hyperspectral domain, which is widely regarded as one of the most effective defenses against adversarial attacks. Through extensive empirical analyses, we demonstrate that while adversarial training does enhance robustness across various models and datasets, hyperspectral data introduces unique challenges not seen in RGB images. Specifically, we find that adversarial noise and the non-smooth nature of adversarial examples can distort or eliminate important spectral semantic information. To mitigate this issue, we employ data augmentation techniques and propose a novel hyperspectral adversarial training method, termed AT-RA. By increasing the diversity of spectral information and ensuring spatial smoothness, AT-RA preserves and corrects spectral semantics in hyperspectral images. Experimental results show that AT-RA improves adversarial robustness by 21.34% against AutoAttack and 18.78% against PGD-50 while boosting benign accuracy by 2.68%.