Rohan Gala

Mayank Sanganeria, Rohan Gala

Recent AI-driven step-function advances in several longstanding problems in music technology are opening up new avenues to create the next generation of music education tools. Creating personalized, engaging, and effective learning experiences are continuously evolving challenges in music education. Here we present two case studies using such advances in music technology to address these challenges. In our first case study we showcase an application that uses Automatic Chord Recognition to generate personalized exercises from audio tracks, connecting traditional ear training with real-world musical contexts. In the second case study we prototype adaptive piano method books that use Automatic Music Transcription to generate exercises at different skill levels while retaining a close connection to musical interests. These applications demonstrate how recent AI developments can democratize access to high-quality music education and promote rich interaction with music in the age of generative AI. We hope this work inspires other efforts in the community, aimed at removing barriers to access to high-quality music education and fostering human participation in musical expression.

Yeganeh M. Marghi, Rohan Gala, Uygar Sümbül

Jointly identifying a mixture of discrete and continuous factors of variability without supervision is a key problem in unraveling complex phenomena. Variational inference has emerged as a promising method to learn interpretable mixture representations. However, posterior approximation in high-dimensional latent spaces, particularly for discrete factors remains challenging. Here, we propose an unsupervised variational framework using multiple interacting networks called cpl-mixVAE that scales well to high-dimensional discrete settings. In this framework, the mixture representation of each network is regularized by imposing a consensus constraint on the discrete factor. We justify the use of this framework by providing both theoretical and experimental results. Finally, we use the proposed method to jointly uncover discrete and continuous factors of variability describing gene expression in a single-cell transcriptomic dataset profiling more than a hundred cortical neuron types.

Rohan Gala, Nathan Gouwens, Zizhen Yao et al.

Recent developments in high throughput profiling of individual neurons have spurred data driven exploration of the idea that there exist natural groupings of neurons referred to as cell types. The promise of this idea is that the immense complexity of brain circuits can be reduced, and effectively studied by means of interactions between cell types. While clustering of neuron populations based on a particular data modality can be used to define cell types, such definitions are often inconsistent across different characterization modalities. We pose this issue of cross-modal alignment as an optimization problem and develop an approach based on coupled training of autoencoders as a framework for such analyses. We apply this framework to a Patch-seq dataset consisting of transcriptomic and electrophysiological profiles for the same set of neurons to study consistency of representations across modalities, and evaluate cross-modal data prediction ability. We explore the problem where only a subset of neurons is characterized with more than one modality, and demonstrate that representations learned by coupled autoencoders can be used to identify types sampled only by a single modality.