Wenbin Liu

Zhongwei Qiu, Hanqing Chao, Tiancheng Lin et al.

Histopathology plays a critical role in medical diagnostics, with whole slide images (WSIs) offering valuable insights that directly influence clinical decision-making. However, the large size and complexity of WSIs may pose significant challenges for deep learning models, in both computational efficiency and effective representation learning. In this work, we introduce Pixel-Mamba, a novel deep learning architecture designed to efficiently handle gigapixel WSIs. Pixel-Mamba leverages the Mamba module, a state-space model (SSM) with linear memory complexity, and incorporates local inductive biases through progressively expanding tokens, akin to convolutional neural networks. This enables Pixel-Mamba to hierarchically combine both local and global information while efficiently addressing computational challenges. Remarkably, Pixel-Mamba achieves or even surpasses the quantitative performance of state-of-the-art (SOTA) foundation models that were pretrained on millions of WSIs or WSI-text pairs, in a range of tumor staging and survival analysis tasks, {\bf even without requiring any pathology-specific pretraining}. Extensive experiments demonstrate the efficacy of Pixel-Mamba as a powerful and efficient framework for end-to-end WSI analysis.

Xingyu Lin, Yilin Wen, En Wang et al.

Group Relative Policy Optimization (GRPO) has significantly advanced the reasoning ability of large language models (LLMs), particularly by boosting their mathematical performance. However, GRPO and related entropy-regularization methods still face challenges rooted in the sparse token rewards inherent to chain-of-thought (CoT). Current approaches often rely on undifferentiated token-level entropy adjustments, which frequently lead to entropy collapse or model collapse. In this work, we propose TEPO, a novel token-level framework that incorporates Markov Likelihood (sequence likelihood) links group-level rewards with tokens via token-level aggregation. Experiments show that TEPO consistently outperforms existing baselines across key metrics (including @k and accuracy). It not only sets a new state of the art on mathematical reasoning tasks but also significantly enhances training stability.