Wei Qian

Yanan Wu, Shuiqing Zhao, Shouliang Qi et al.

Accurate airway extraction from computed tomography (CT) images is a critical step for planning navigation bronchoscopy and quantitative assessment of airway-related chronic obstructive pulmonary disease (COPD). The existing methods are challenging to sufficiently segment the airway, especially the high-generation airway, with the constraint of the limited label and cannot meet the clinical use in COPD. We propose a novel two-stage 3D contextual transformer-based U-Net for airway segmentation using CT images. The method consists of two stages, performing initial and refined airway segmentation. The two-stage model shares the same subnetwork with different airway masks as input. Contextual transformer block is performed both in the encoder and decoder path of the subnetwork to finish high-quality airway segmentation effectively. In the first stage, the total airway mask and CT images are provided to the subnetwork, and the intrapulmonary airway mask and corresponding CT scans to the subnetwork in the second stage. Then the predictions of the two-stage method are merged as the final prediction. Extensive experiments were performed on in-house and multiple public datasets. Quantitative and qualitative analysis demonstrate that our proposed method extracted much more branches and lengths of the tree while accomplishing state-of-the-art airway segmentation performance. The code is available at https://github.com/zhaozsq/airway_segmentation.

Haoming Zhuang, Beibei Li, Jingtong Ma et al.

Background: Ovarian cancer is among the three most frequent gynecologic cancers globally. High-grade serous ovarian cancer (HGSOC) is the most common and aggressive histological type. Guided treatment for HGSOC typically involves platinum-based combination chemotherapy, necessitating an assessment of whether the patient is platinum-resistant. The purpose of this study is to propose a deep learning-based method to determine whether a patient is platinum-resistant using multimodal positron emission tomography/computed tomography (PET/CT) images. Methods: 289 patients with HGSOC were included in this study. An end-to-end SE-SPP-DenseNet model was built by adding Squeeze-Excitation Block (SE Block) and Spatial Pyramid Pooling Layer (SPPLayer) to Dense Convolutional Network (DenseNet). Multimodal data from PET/CT images of the regions of interest (ROI) were used to predict platinum resistance in patients. Results: Through five-fold cross-validation, SE-SPP-DenseNet achieved a high accuracy rate and an area under the curve (AUC) in predicting platinum resistance in patients, which were 92.6% and 0.93, respectively. The importance of incorporating SE Block and SPPLayer into the deep learning model, and considering multimodal data was substantiated by carrying out ablation studies and experiments with single modality data. Conclusions: The obtained classification results indicate that our proposed deep learning framework performs better in predicting platinum resistance in patients, which can help gynecologists make better treatment decisions. Keywords: PET/CT, CNN, SE Block, SPP Layer, Platinum resistance, Ovarian cancer

Guantian Huang, Beibei Li, Xiaobing Fan et al.

Accurate segmentation of various regions within the prostate is pivotal for diagnosing and treating prostate-related diseases. However, the scarcity of labeled data, particularly in specialized medical fields like prostate imaging, poses a significant challenge. Segment Anything Model (SAM) is a new large model for natural image segmentation, but there are some challenges in medical imaging. In order to better utilize the powerful feature extraction capability of SAM as well as to address the problem of low data volume for medical image annotation, we use Low-Rank Adaptation (LoRA) and semi-supervised learning methods of Monte Carlo guided interpolation consistency (MCIC) to enhance the fine-tuned SAM. We propose Monte Carlo-guided Interpolation Consistency Segment Anything Model (MCICSAM) for application to semi-supervised learning based prostate region segmentation. In the unlabeled data section, MCIC performs two different interpolation transformations on the input data and incorporates Monte Carlo uncertainty analysis in the output, forcing the model to be consistent in its predictions. The consistency constraints imposed on these interpolated samples allow the model to fit the distribution of unlabeled data better, ultimately improving its performance in semi-supervised scenarios. We use Dice and Hausdorff Distance at 95th percentile (HD95) to validate model performance. MCICSAM yieldes Dice with 79.38% and 89.95%, along with improves HD95 values of 3.12 and 2.27 for transition zone and transition zone. At the same time MCICSAM demonstrates strong generalizability. This method is expected to bring new possibilities in the field of prostate image segmentation.

Chenxu Zhao, Wei Qian, Aobo Chen et al.

Recent studies have shown that deep learning models are vulnerable to membership inference attacks (MIAs), which aim to infer whether a data record was used to train a target model or not. To analyze and study these vulnerabilities, various MIA methods have been proposed. Despite the significance and popularity of MIAs, existing works on MIAs are limited in providing guarantees on the false discovery rate (FDR), which refers to the expected proportion of false discoveries among the identified positive discoveries. However, it is very challenging to ensure the false discovery rate guarantees, because the underlying distribution is usually unknown, and the estimated non-member probabilities often exhibit interdependence. To tackle the above challenges, in this paper, we design a novel membership inference attack method, which can provide the guarantees on the false discovery rate. Additionally, we show that our method can also provide the marginal probability guarantee on labeling true non-member data as member data. Notably, our method can work as a wrapper that can be seamlessly integrated with existing MIA methods in a post-hoc manner, while also providing the FDR control. We perform the theoretical analysis for our method. Extensive experiments in various settings (e.g., the black-box setting and the lifelong learning setting) are also conducted to verify the desirable performance of our method.