Kun Li

Wenjin Hou, Dingjie Fu, Kun Li et al.

Zero-shot learning (ZSL) aims to recognize unseen classes by transferring semantic knowledge from seen classes to unseen ones, guided by semantic information. To this end, existing works have demonstrated remarkable performance by utilizing global visual features from Convolutional Neural Networks (CNNs) or Vision Transformers (ViTs) for visual-semantic interactions. Due to the limited receptive fields of CNNs and the quadratic complexity of ViTs, however, these visual backbones achieve suboptimal visual-semantic interactions. In this paper, motivated by the visual state space model (i.e., Vision Mamba), which is capable of capturing long-range dependencies and modeling complex visual dynamics, we propose a parameter-efficient ZSL framework called ZeroMamba to advance ZSL. Our ZeroMamba comprises three key components: Semantic-aware Local Projection (SLP), Global Representation Learning (GRL), and Semantic Fusion (SeF). Specifically, SLP integrates semantic embeddings to map visual features to local semantic-related representations, while GRL encourages the model to learn global semantic representations. SeF combines these two semantic representations to enhance the discriminability of semantic features. We incorporate these designs into Vision Mamba, forming an end-to-end ZSL framework. As a result, the learned semantic representations are better suited for classification. Through extensive experiments on four prominent ZSL benchmarks, ZeroMamba demonstrates superior performance, significantly outperforming the state-of-the-art (i.e., CNN-based and ViT-based) methods under both conventional ZSL (CZSL) and generalized ZSL (GZSL) settings. Code is available at: https://anonymous.4open.science/r/ZeroMamba.

Kun Li, Dan Guo, Meng Wang

The video grounding (VG) task aims to locate the queried action or event in an untrimmed video based on rich linguistic descriptions. Existing proposal-free methods are trapped in complex interaction between video and query, overemphasizing cross-modal feature fusion and feature correlation for VG. In this paper, we propose a novel boundary regression paradigm that performs regression token learning in a transformer. Particularly, we present a simple but effective proposal-free framework, namely Video Grounding Transformer (ViGT), which predicts the temporal boundary using a learnable regression token rather than multi-modal or cross-modal features. In ViGT, the benefits of a learnable token are manifested as follows. (1) The token is unrelated to the video or the query and avoids data bias toward the original video and query. (2) The token simultaneously performs global context aggregation from video and query features. First, we employed a sharing feature encoder to project both video and query into a joint feature space before performing cross-modal co-attention (i.e., video-to-query attention and query-to-video attention) to highlight discriminative features in each modality. Furthermore, we concatenated a learnable regression token [REG] with the video and query features as the input of a vision-language transformer. Finally, we utilized the token [REG] to predict the target moment and visual features to constrain the foreground and background probabilities at each timestamp. The proposed ViGT performed well on three public datasets: ANet Captions, TACoS and YouCookII. Extensive ablation studies and qualitative analysis further validated the interpretability of ViGT.

Kun Li, Yong Luo, Xiantao Cai et al.

Conventional deep learning methods typically employ supervised learning for drug response prediction (DRP). This entails dependence on labeled response data from drugs for model training. However, practical applications in the preclinical drug screening phase demand that DRP models predict responses for novel compounds, often with unknown drug responses. This presents a challenge, rendering supervised deep learning methods unsuitable for such scenarios. In this paper, we propose a zero-shot learning solution for the DRP task in preclinical drug screening. Specifically, we propose a Multi-branch Multi-Source Domain Adaptation Test Enhancement Plug-in, called MSDA. MSDA can be seamlessly integrated with conventional DRP methods, learning invariant features from the prior response data of similar drugs to enhance real-time predictions of unlabeled compounds. We conducted experiments using the GDSCv2 and CellMiner datasets. The results demonstrate that MSDA efficiently predicts drug responses for novel compounds, leading to a general performance improvement of 5-10\% in the preclinical drug screening phase. The significance of this solution resides in its potential to accelerate the drug discovery process, improve drug candidate assessment, and facilitate the success of drug discovery.

Kun Li, Jia Wu, Bo Du et al.

GNN-based methods have achieved excellent results as a mainstream task in drug response prediction tasks in recent years. Traditional GNN methods use only the atoms in a drug molecule as nodes to obtain the representation of the molecular graph through node information passing, whereas the method using the transformer can only extract information about the nodes. However, the covalent bonding and chirality of a drug molecule have a great influence on the pharmacological properties of the molecule, and these information are implied in the chemical bonds formed by the edges between the atoms. In addition, CNN methods for modelling cell lines genomics sequences can only perceive local rather than global information about the sequence. In order to solve the above problems, we propose the decoupled dual transformer structure with edge embedded for drug respond prediction (TransEDRP), which is used for the representation of cell line genomics and drug respectively. For the drug branch, we encoded the chemical bond information within the molecule as the embedding of the edge in the molecular graph, extracted the global structural and biochemical information of the drug molecule using graph transformer. For the branch of cell lines genomics, we use the multi-headed attention mechanism to globally represent the genomics sequence. Finally, the drug and genomics branches are fused to predict IC50 values through the transformer layer and the fully connected layer, which two branches are different modalities. Extensive experiments have shown that our method is better than the current mainstream approach in all evaluation indicators.

Kun Li, Wenbin Hu

Deep learning-based drug response prediction (DRP) methods can accelerate the drug discovery process and reduce R\&D costs. Although the mainstream methods achieve high accuracy in predicting response regression values, the regression-aware representations of these methods are fragmented and fail to capture the continuity of the sample order. This phenomenon leads to models optimized to sub-optimal solution spaces, reducing generalization ability and may result in significant wasted costs in the drug discovery phase. In this paper, we propose \MN, a contrastive learning framework with natural language supervision for the DRP. The \MN~converts regression labels into text, which is merged with the captions text of the drug response as a second modality of the samples compared to the traditional modalities (graph, sequence). In each batch, two modalities of one sample are considered positive pairs and the other pairs are considered negative pairs. At the same time, in order to enhance the continuous representation capability of the numerical text, a common-sense numerical knowledge graph is introduced. We validated several hundred thousand samples from the Genomics of Drug Sensitivity in Cancer dataset, observing the average improvement of the DRP method ranges from 7.8\% to 31.4\% with the application of our framework. The experiments prove that the \MN~effectively constrains the samples to a continuous distribution in the representation space, and achieves impressive prediction performance with only a few epochs of fine-tuning after pre-training. The code is available at: \url{https://gitee.com/xiaoyibang/clipdrug.git}.

Xinwei Chen, Kun Li, Tianyou Song et al.

Named Entity Recognition (NER) is an essential steppingstone in the field of natural language processing. Although promising performance has been achieved by various distantly supervised models, we argue that distant supervision inevitably introduces incomplete and noisy annotations, which may mislead the model training process. To address this issue, we propose a robust NER model named BOND-MoE based on Mixture of Experts (MoE). Instead of relying on a single model for NER prediction, multiple models are trained and ensembled under the Expectation-Maximization (EM) framework, so that noisy supervision can be dramatically alleviated. In addition, we introduce a fair assignment module to balance the document-model assignment process. Extensive experiments on real-world datasets show that the proposed method achieves state-of-the-art performance compared with other distantly supervised NER.