Maxx Richard Rahman

Sahil Rahman, Maxx Richard Rahman

Protein language models (PLMs) are passive oracles: they generate sequences in a single forward pass with no mechanism to consult external biophysical feedback or redirect generation when a candidate violates thermodynamic or structural constraints. We introduce AgentPLM, which addresses this by equipping a pre-trained PLM with i) Reasoning-Augmented Decoding (RAD), which interleaves autoregressive generation with tool calls (ESMFold, FoldX, AutoDock Vina), and ii) Contrastive Agent Policy Optimisation (CAPO), a trajectory-level extension of direct preference optimisation that trains the policy end-to-end to learn when oracle feedback is informative rather than merely imitating high-fitness sequences. We evaluate AgentPLM on benchmark tasks spanning de novo enzyme design, antibody optimisation, thermostability, PPI interface design, and zero-shot fitness prediction with standardised oracle APIs and controlled sequence-identity splits. AgentPLM achieves state-of-the-art results with a gain in antibody top-10% hit rate over the strongest passive baseline, providing mechanistic evidence of online error correction without explicit backtracking.

Angela John, Theophilus Aidoo, Hamayoon Behmanush et al.

Recommendation systems are ubiquitous, from Spotify playlist suggestions to Amazon product suggestions. Nevertheless, depending on the methodology or the dataset, these systems typically fail to capture user preferences and generate general recommendations. Recent advancements in Large Language Models (LLM) offer promising results for analyzing user queries. However, employing these models to capture user preferences and efficiency remains an open question. In this paper, we propose LLMRS, an LLM-based zero-shot recommender system where we employ pre-trained LLM to encode user reviews into a review score and generate user-tailored recommendations. We experimented with LLMRS on a real-world dataset, the Amazon product reviews, for software purchase use cases. The results show that LLMRS outperforms the ranking-based baseline model while successfully capturing meaningful information from product reviews, thereby providing more reliable recommendations.

Zaynab Batool Reza, Abdul Rafay Syed, Omer Iqbal et al.

In an era where digital security is crucial, efficient processing of security-related inquiries through supply chain security questionnaires is imperative. This paper introduces a novel approach using Natural Language Processing (NLP) and Retrieval-Augmented Generation (RAG) to automate these responses. We developed QuestSecure, a system that interprets diverse document formats and generates precise responses by integrating large language models (LLMs) with an advanced retrieval system. Our experiments show that QuestSecure significantly improves response accuracy and operational efficiency. By employing advanced NLP techniques and tailored retrieval mechanisms, the system consistently produces contextually relevant and semantically rich responses, reducing cognitive load on security teams and minimizing potential errors. This research offers promising avenues for automating complex security management tasks, enhancing organizational security processes.

Maxx Richard Rahman, Jacob Bejder, Thomas Christian Bonne et al.

Sports officials around the world are facing incredible challenges due to the unfair means of practices performed by the athletes to improve their performance in the game. It includes the intake of hormonal based drugs or transfusion of blood to increase their strength and the result of their training. However, the current direct test of detection of these cases includes the laboratory-based method, which is limited because of the cost factors, availability of medical experts, etc. This leads us to seek for indirect tests. With the growing interest of Artificial Intelligence in healthcare, it is important to propose an algorithm based on blood parameters to improve decision making. In this paper, we proposed a statistical and machine learning-based approach to identify the presence of doping substance rhEPO in blood samples.