Lang Li

Xuanhua He, Lang Li, Yingying Wang et al.

Image restoration aims to reconstruct the latent clear images from their degraded versions. Despite the notable achievement, existing methods predominantly focus on handling specific degradation types and thus require specialized models, impeding real-world applications in dynamic degradation scenarios. To address this issue, we propose Large Model Driven Image Restoration framework (LMDIR), a novel multiple-in-one image restoration paradigm that leverages the generic priors from large multi-modal language models (MMLMs) and the pretrained diffusion models. In detail, LMDIR integrates three key prior knowledges: 1) global degradation knowledge from MMLMs, 2) scene-aware contextual descriptions generated by MMLMs, and 3) fine-grained high-quality reference images synthesized by diffusion models guided by MMLM descriptions. Standing on above priors, our architecture comprises a query-based prompt encoder, degradation-aware transformer block injecting global degradation knowledge, content-aware transformer block incorporating scene description, and reference-based transformer block incorporating fine-grained image priors. This design facilitates single-stage training paradigm to address various degradations while supporting both automatic and user-guided restoration. Extensive experiments demonstrate that our designed method outperforms state-of-the-art competitors on multiple evaluation benchmarks.

Wen-Hao Chiang, Li Shen, Lang Li et al.

Background: The problem of predicting whether a drug combination of arbitrary orders is likely to induce adverse drug reactions is considered in this manuscript. Methods: Novel kernels over drug combinations of arbitrary orders are developed within support vector machines for the prediction. Graph matching methods are used in the novel kernels to measure the similarities among drug combinations, in which drug co-medication patterns are leveraged to measure single drug similarities. Results: The experimental results on a real-world dataset demonstrated that the new kernels achieve an area under the curve (AUC) value 0.912 for the prediction problem. Conclusions: The new methods with drug co-medication based single drug similarities can accurately predict whether a drug combination is likely to induce adverse drug reactions of interest. Keywords: drug-drug interaction prediction; drug combination similarity; co-medication; graph matching

Wen-Hao Chiang, Li Shen, Lang Li et al.

Adverse drug reactions (ADRs) induced from high-order drug-drug interactions (DDIs) due to polypharmacy represent a significant public health problem. In this paper, we formally formulate the to-avoid and safe (with respect to ADRs) drug recommendation problems when multiple drugs have been taken simultaneously. We develop a joint model with a recommendation component and an ADR label prediction component to recommend for a prescription a set of to-avoid drugs that will induce ADRs if taken together with the prescription. We also develop real drug-drug interaction datasets and corresponding evaluation protocols. Our experimental results on real datasets demonstrate the strong performance of the joint model compared to other baseline methods.