Shiqi Wang

Zetian Song, Wenhong Duan, Yuhuai Zhang et al.

Representing the Neural Radiance Field (NeRF) with the explicit voxel grid (EVG) is a promising direction for improving NeRFs. However, the EVG representation is not efficient for storage and transmission because of the terrific memory cost. Current methods for compressing EVG mainly inherit the methods designed for neural network compression, such as pruning and quantization, which do not take full advantage of the spatial correlation of voxels. Inspired by prosperous digital image compression techniques, this paper proposes SPC-NeRF, a novel framework applying spatial predictive coding in EVG compression. The proposed framework can remove spatial redundancy efficiently for better compression performance.Moreover, we model the bitrate and design a novel form of the loss function, where we can jointly optimize compression ratio and distortion to achieve higher coding efficiency. Extensive experiments demonstrate that our method can achieve 32% bit saving compared to the state-of-the-art method VQRF on multiple representative test datasets, with comparable training time.

Han Liu, Keyan Ding, Peilin Chen et al.

Accurate prediction of protein-ligand binding affinity is critical for drug discovery. While recent deep learning approaches have demonstrated promising results, they often rely solely on structural features of proteins and ligands, overlooking their valuable biochemical knowledge associated with binding affinity. To address this limitation, we propose KEPLA, a novel deep learning framework that explicitly integrates prior knowledge from Gene Ontology and ligand properties to enhance prediction performance. KEPLA takes protein sequences and ligand molecular graphs as input and optimizes two complementary objectives: (1) aligning global representations with knowledge graph relations to capture domain-specific biochemical insights, and (2) leveraging cross attention between local representations to construct fine-grained joint embeddings for prediction. Experiments on two benchmark datasets across both in-domain and cross-domain scenarios demonstrate that KEPLA consistently outperforms state-of-the-art baselines. Furthermore, interpretability analyses based on knowledge graph relations and cross attention maps provide valuable insights into the underlying predictive mechanisms.