Mo Chen

Mo Chen, Jaime F. Fisac, Shankar Sastry et al.

We consider the problem of planning trajectories for a group of $N$ vehicles, each aiming to reach its own target set while avoiding danger zones of other vehicles. The analysis of problems like this is extremely important practically, especially given the growing interest in utilizing unmanned aircraft systems for civil purposes. The direct solution of this problem by solving a single-obstacle Hamilton-Jacobi-Isaacs (HJI) variational inequality (VI) is numerically intractable due to the exponential scaling of computation complexity with problem dimensionality. Furthermore, the single-obstacle HJI VI cannot directly handle situations in which vehicles do not have a common scheduled arrival time. Instead, we perform sequential path planning by considering vehicles in order of priority, modeling higher-priority vehicles as time-varying obstacles for lower-priority vehicles. To do this, we solve a double-obstacle HJI VI which allows us to obtain the reach-avoid set, defined as the set of states from which a vehicle can reach its target while staying within a time-varying state constraint set. From the solution of the double-obstacle HJI VI, we can also extract the latest start time and the optimal control for each vehicle. This is a first application of the double-obstacle HJI VI which can handle systems with time-varying dynamics, target sets, and state constraint sets, and results in computation complexity that scales linearly, as opposed to exponentially, with the number of vehicles in consideration.

Xubo Lyu, Hanyang Hu, Seth Siriya et al.

We present task-oriented Koopman-based control that utilizes end-to-end reinforcement learning and contrastive encoder to simultaneously learn the Koopman latent embedding, operator, and associated linear controller within an iterative loop. By prioritizing the task cost as the main objective for controller learning, we reduce the reliance of controller design on a well-identified model, which, for the first time to the best of our knowledge, extends Koopman control from low to high-dimensional, complex nonlinear systems, including pixel-based tasks and a real robot with lidar observations. Code and videos are available \href{https://sites.google.com/view/kpmlilatsupp/}{here}.

Mo Chen, Minsheng Hao, Xinquan Liu et al.

Cells in multicellular organisms coordinate to form functional and structural niches. With spatial transcriptomics enabling gene expression profiling in spatial contexts, it has been revealed that spatial niches serve as cohesive and recurrent units in physiological and pathological processes. These observations suggest universal tissue organization principles encoded by conserved niche patterns, and call for a query-based niche analytical paradigm beyond current computational tools. In this work, we defined the Niche Query Task, which is to identify similar niches across ST samples given a niche of interest (NOI). We further developed QueST, a specialized method for solving this task. QueST models each niche as a subgraph, uses contrastive learning to learn discriminative niche embeddings, and incorporates adversarial training to mitigate batch effects. In simulations and benchmark datasets, QueST outperformed existing methods repurposed for niche querying, accurately capturing niche structures in heterogeneous environments and demonstrating strong generalizability across diverse sequencing platforms. Applied to tertiary lymphoid structures in renal and lung cancers, QueST revealed functionally distinct niches associated with patient prognosis and uncovered conserved and divergent spatial architectures across cancer types. These results demonstrate that QueST enables systematic, quantitative profiling of spatial niches across samples, providing a powerful tool to dissect spatial tissue architecture in health and disease.

Xinyu Zhao, Razvan C. Fetecau, Mo Chen

Collaborative autonomous multi-agent systems covering a specified area have many potential applications, such as UAV search and rescue, forest fire fighting, and real-time high-resolution monitoring. Traditional approaches for such coverage problems involve designing a model-based control policy based on sensor data. However, designing model-based controllers is challenging, and the state-of-the-art classical control policy still exhibits a large degree of sub-optimality. In this paper, we present a reinforcement learning (RL) approach for the multi-agent efficient domain coverage problem involving agents with second-order dynamics. Our approach is based on the Multi-Agent Proximal Policy Optimization Algorithm (MAPPO). Our proposed network architecture includes the incorporation of LSTM and self-attention, which allows the trained policy to adapt to a variable number of agents. Our trained policy significantly outperforms the state-of-the-art classical control policy. We demonstrate our proposed method in a variety of simulated experiments.

Xubo Lyu, Amin Banitalebi-Dehkordi, Mo Chen et al.

Cooperative multi-agent problems often require coordination between agents, which can be achieved through a centralized policy that considers the global state. Multi-agent policy gradient (MAPG) methods are commonly used to learn such policies, but they are often limited to problems with low-level action spaces. In complex problems with large state and action spaces, it is advantageous to extend MAPG methods to use higher-level actions, also known as options, to improve the policy search efficiency. However, multi-robot option executions are often asynchronous, that is, agents may select and complete their options at different time steps. This makes it difficult for MAPG methods to derive a centralized policy and evaluate its gradient, as centralized policy always select new options at the same time. In this work, we propose a novel, conditional reasoning approach to address this problem and demonstrate its effectiveness on representative option-based multi-agent cooperative tasks through empirical validation. Find code and videos at: \href{https://sites.google.com/view/mahrlsupp/}{https://sites.google.com/view/mahrlsupp/}