Thanh Nguyen

Trung Xuan Pham, Jin Woong Choi, Rusty John Lloyd Mina et al.

Herein, we introduce "Look and Diagnose" (LAD), a hybrid deep learning-based system that aims to support doctors in the medical field in diagnosing effectively the Benign Paroxysmal Positional Vertigo (BPPV) disorder. Given the body postures of the patient in the Dix-Hallpike and lateral head turns test, the visual information of both eyes is captured and fed into LAD for analyzing and classifying into one of six possible disorders the patient might be suffering from. The proposed system consists of two streams: (1) an RNN-based stream that takes raw RGB images of both eyes to extract visual features and optical flow of each eye followed by ternary classification to determine left/right posterior canal (PC) or other; and (2) pupil detector stream that detects the pupil when it is classified as Non-PC and classifies the direction and strength of the beating to categorize the Non-PC types into the remaining four classes: Geotropic BPPV (left and right) and Apogeotropic BPPV (left and right). Experimental results show that with the patient's body postures, the system can accurately classify given BPPV disorder into the six types of disorders with an accuracy of 91% on the validation set. The proposed method can successfully classify disorders with an accuracy of 93% for the Posterior Canal disorder and 95% for the Geotropic and Apogeotropic disorder, paving a potential direction for research with the medical data.

Ha Luu, Mert Sisman, Ilhami Kovanlikaya et al.

Paramagnetic rim lesions (PRLs) are an emerging biomarker in multiple sclerosis (MS). Manual identification and rim segmentation of PRLs on quantitative susceptibility mapping (QSM) images are time-consuming. Deep learning-based QSM-RimNet can provide automated PRL detection, but this method does not provide rim segmentation for microglial density quantification and requires precise QSM lesion masks. The purpose of this study is to develop a U-Net-based QSM-RimDS method for joint PRL detection and rim segmentation using readily available T2-weighted (T2W) fluid-attenuated inversion recovery (FLAIR) lesion masks. Two expert readers performed PRL classification and rim segmentation as the reference. Dice similarity coefficient (DSC) was used to assess the agreement between rim segmentation obtained by QSM-RimDS and the manual expert segmentation. The PRL detection performances of QSM-RimDS and QSM-RimNet were evaluated using receiver operating characteristic (ROC) and precision-recall (PR) plots in a five-fold cross validation. A total of 260 PRLs (3.3\%) and 7720 non-PRLs (96.7\%) were identified by the readers. Compared to the expert rim segmentation, QSM-RimDS provided a mean DSC of 0.57 \pm 0.02 with moderate to high agreement (DSC \leq 0.5) in 73.8pm 5.7\% of PRLs over five folds. QSM-RimDS produced better and more consistent detection performance with a mean area under curve (AUC) of 0.754 \pm 0.037 vs. 0.514 \pm 0.121 by QSM-RimNet (46.7\% improvement) on PR plots, and 0.956 \pm 0.034 vs. 0.908 \pm 0.073 (5.3\% improvement) on ROC plots. In conclusion, QSM-RimDS improves PRL detection accuracy compared to QSM-RimNet and unlike QSM-RimNet can provide reasonably accurate rim segmentation.