Gong Chen

Chen Gong, Yue Chen, Yanan Sui et al.

The detection of human sleep stages is widely used in the diagnosis and intervention of neurological and psychiatric diseases. Some patients with deep brain stimulator implanted could have their neural activities recorded from the deep brain. Sleep stage classification based on deep brain recording has great potential to provide more precise treatment for patients. The accuracy and generalizability of existing sleep stage classifiers based on local field potentials are still limited. We proposed an applicable cross-modal transfer learning method for sleep stage classification with implanted devices. This end-to-end deep learning model contained cross-modal self-supervised feature representation, self-attention, and classification framework. We tested the model with deep brain recording data from 12 patients with Parkinson's disease. The best total accuracy reached 83.2% for sleep stage classification. Results showed speech self-supervised features catch the conversion pattern of sleep stages effectively. We provide a new method on transfer learning from acoustic signals to local field potentials. This method supports an effective solution for the insufficient scale of clinical data. This sleep stage classification model could be adapted to chronic and continuous monitor sleep for Parkinson's patients in daily life, and potentially utilized for more precise treatment in deep brain-machine interfaces, such as closed-loop deep brain stimulation.

Yiliu Sun, Zicheng Zhao, Sheng Wan et al.

Nowadays, single Large Language Model (LLM) struggles with critical issues such as hallucination and inadequate reasoning abilities. To mitigate these issues, Multi-Agent Debate (MAD) has emerged as an effective strategy, where LLM agents engage in in-depth debates with others on tasks. However, existing MAD methods face two major issues: (a) too lengthy input contexts, which causes LLM agents to get lost in plenty of input information and experiences performance drop; and (b) the overconfidence dilemma, where self-assured LLM agents dominate the debate, leading to low debating effectiveness. To address these limitations, we propose a novel MAD method called "CortexDebate". Inspired by the human brain's tendency to establish a sparse and dynamically optimized network among cortical areas governed by white matter, CortexDebate constructs a sparse debating graph among LLM agents, where each LLM agent only debates with the ones that are helpful to it. To optimize the graph, we propose a module named McKinsey-based Debate Matter (MDM), which acts as an artificial analog to white matter. By integrating the McKinsey Trust Formula, a well-established measure of trustworthiness from sociology, MDM enables credible evaluations that guide graph optimization. The effectiveness of our CortexDebate has been well demonstrated by extensive experimental results across eight datasets from four task types.