Kang Liu

Wei Peng, Kang Liu, Jiaxi Shi et al.

The electroencephalography (EEG)-based motor imagery (MI) classification is a critical and challenging task in brain-computer interface (BCI) technology, which plays a significant role in assisting patients with functional impairments to regain mobility. We present a novel multi-scale atrous convolutional neural network (CNN) model called EEG-dilated convolution network (DCNet) to enhance the accuracy and efficiency of the EEG-based MI classification tasks. We incorporate the $1\times1$ convolutional layer and utilize the multi-branch parallel atrous convolutional architecture in EEG-DCNet to capture the highly nonlinear characteristics and multi-scale features of the EEG signals. Moreover, we utilize the sliding window to enhance the temporal consistency and utilize the attension mechanism to improve the accuracy of recognizing user intentions. The experimental results (via the BCI-IV-2a ,BCI-IV-2b and the High-Gamma datasets) show that EEG-DCNet outperforms existing state-of-the-art (SOTA) approaches in terms of classification accuracy and Kappa scores. Furthermore, since EEG-DCNet requires less number of parameters, the training efficiency and memory consumption are also improved. The experiment code is open-sourced at \href{https://github.com/Kanyooo/EEG-DCNet}{here}.

Xu Han, Yuancheng Sun, Kai Chen et al.

Coarse-grained(CG) molecular dynamics simulations offer computational efficiency for exploring protein conformational ensembles and thermodynamic properties. Though coarse representations enable large-scale simulations across extended temporal and spatial ranges, the sacrifice of atomic-level details limits their utility in tasks such as ligand docking and protein-protein interaction prediction. Backmapping, the process of reconstructing all-atom structures from coarse-grained representations, is crucial for recovering these fine details. While recent machine learning methods have made strides in protein structure generation, challenges persist in reconstructing diverse atomistic conformations that maintain geometric accuracy and chemical validity. In this paper, we present Latent Diffusion Backmapping (LDB), a novel approach leveraging denoising diffusion within latent space to address these challenges. By combining discrete latent encoding with diffusion, LDB bypasses the need for equivariant and internal coordinate manipulation, significantly simplifying the training and sampling processes as well as facilitating better and wider exploration in configuration space. We evaluate LDB's state-of-the-art performance on three distinct protein datasets, demonstrating its ability to efficiently reconstruct structures with high structural accuracy and chemical validity. Moreover, LDB shows exceptional versatility in capturing diverse protein ensembles, highlighting its capability to explore intricate conformational spaces. Our results position LDB as a powerful and scalable approach for backmapping, effectively bridging the gap between CG simulations and atomic-level analyses in computational biology.