Ting Chen

Yihua Chen, Xingle Que, Jiashuo Zhang et al.

In recent years, unmanned aerial vehicles (UAVs) have become increasingly popular in our daily lives and have attracted significant research interest in software engineering. At the same time, large language models (LLMs) have made notable advancements in language understanding, reasoning, and generation, making LLM applications in UAVs a promising research direction. However, existing studies have largely remained in preliminary exploration with a limited understanding of real-world practice, which causes an academia-industry gap and hinders the application of LLMs in UAVs. To address this, we conducted the first empirical study to investigate how LLMs support UAVs. To characterize common tasks and application scenarios of real-world UAV-LLM practices, we conducted a large-scale empirical study involving 997 research papers and 1,509 GitHub projects. The results classified nine common tasks (e.g., Natural Language Command Parsing) in four UAV workflows (e.g., Information Input) undertaken by LLMs in real-world UAV projects and revealed a large difference in the task distribution of research efforts and industry practices. To gain deeper insight into these differences and understand developers' perspectives on the application of LLMs in UAVs, we conducted a survey of practitioners, receiving 52 valid responses from 15 countries. The results revealed that while 40.4% of developers have attempted to apply LLMs to UAV tasks, 59.6% still face challenges integrating their UAV projects with advanced LLM capabilities. Their feedback attributes these challenges to five factors, including technological maturity, performance, safety, cost, and others, and provides practical implications for researchers and developers in conducting UAV-LLM practices.

Ting Chen, Ruixiang Zhang, Geoffrey Hinton

We present Bit Diffusion: a simple and generic approach for generating discrete data with continuous state and continuous time diffusion models. The main idea behind our approach is to first represent the discrete data as binary bits, and then train a continuous diffusion model to model these bits as real numbers which we call analog bits. To generate samples, the model first generates the analog bits, which are then thresholded to obtain the bits that represent the discrete variables. We further propose two simple techniques, namely Self-Conditioning and Asymmetric Time Intervals, which lead to a significant improvement in sample quality. Despite its simplicity, the proposed approach can achieve strong performance in both discrete image generation and image captioning tasks. For discrete image generation, we significantly improve previous state-of-the-art on both CIFAR-10 (which has 3K discrete 8-bit tokens) and ImageNet-64x64 (which has 12K discrete 8-bit tokens), outperforming the best autoregressive model in both sample quality (measured by FID) and efficiency. For image captioning on MS-COCO dataset, our approach achieves competitive results compared to autoregressive models.

Yuanbo Wen, Tao Gao, Jing Zhang et al.

The profound accumulation of precipitation during intense rainfall events can markedly degrade the quality of images, leading to the erosion of textural details. Despite the improvements observed in existing learning-based methods specialized for heavy rain removal, it is discerned that a significant proportion of these methods tend to overlook the precise reconstruction of the intricate details. In this work, we introduce a simple dual-stage progressive enhancement network, denoted as DPENet, aiming to achieve effective deraining while preserving the structural accuracy of rain-free images. This approach comprises two key modules, a rain streaks removal network (R$^2$Net) focusing on accurate rain removal, and a details reconstruction network (DRNet) designed to recover the textural details of rain-free images. Firstly, we introduce a dilated dense residual block (DDRB) within R$^2$Net, enabling the aggregation of high-level and low-level features. Secondly, an enhanced residual pixel-wise attention block (ERPAB) is integrated into DRNet to facilitate the incorporation of contextual information. To further enhance the fidelity of our approach, we employ a comprehensive loss function that accentuates both the marginal and regional accuracy of rain-free images. Extensive experiments conducted on publicly available benchmarks demonstrates the noteworthy efficiency and effectiveness of our proposed DPENet. The source code and pre-trained models are currently available at \url{https://github.com/chdwyb/DPENet}.

Ting Chen, Saurabh Saxena, Lala Li et al.

While language tasks are naturally expressed in a single, unified, modeling framework, i.e., generating sequences of tokens, this has not been the case in computer vision. As a result, there is a proliferation of distinct architectures and loss functions for different vision tasks. In this work we show that a diverse set of "core" computer vision tasks can also be unified if formulated in terms of a shared pixel-to-sequence interface. We focus on four tasks, namely, object detection, instance segmentation, keypoint detection, and image captioning, all with diverse types of outputs, e.g., bounding boxes or dense masks. Despite that, by formulating the output of each task as a sequence of discrete tokens with a unified interface, we show that one can train a neural network with a single model architecture and loss function on all these tasks, with no task-specific customization. To solve a specific task, we use a short prompt as task description, and the sequence output adapts to the prompt so it can produce task-specific output. We show that such a model can achieve competitive performance compared to well-established task-specific models.

Ting Chen, Lala Li, Saurabh Saxena et al.

Panoptic segmentation assigns semantic and instance ID labels to every pixel of an image. As permutations of instance IDs are also valid solutions, the task requires learning of high-dimensional one-to-many mapping. As a result, state-of-the-art approaches use customized architectures and task-specific loss functions. We formulate panoptic segmentation as a discrete data generation problem, without relying on inductive bias of the task. A diffusion model is proposed to model panoptic masks, with a simple architecture and generic loss function. By simply adding past predictions as a conditioning signal, our method is capable of modeling video (in a streaming setting) and thereby learns to track object instances automatically. With extensive experiments, we demonstrate that our simple approach can perform competitively to state-of-the-art specialist methods in similar settings.

Guangyu Wang, Jingkun Yue, Siqi Zhang et al.

A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation. We outline the data infrastructure, evaluation benchmarks, safety constraints and governance frameworks required. Biomedical world models may provide a foundation for simulation-guided, closed-loop and experimentally actionable biomedical discovery.

Allan Jabri, David Fleet, Ting Chen

Natural data is redundant yet predominant architectures tile computation uniformly across their input and output space. We propose the Recurrent Interface Networks (RINs), an attention-based architecture that decouples its core computation from the dimensionality of the data, enabling adaptive computation for more scalable generation of high-dimensional data. RINs focus the bulk of computation (i.e. global self-attention) on a set of latent tokens, using cross-attention to read and write (i.e. route) information between latent and data tokens. Stacking RIN blocks allows bottom-up (data to latent) and top-down (latent to data) feedback, leading to deeper and more expressive routing. While this routing introduces challenges, this is less problematic in recurrent computation settings where the task (and routing problem) changes gradually, such as iterative generation with diffusion models. We show how to leverage recurrence by conditioning the latent tokens at each forward pass of the reverse diffusion process with those from prior computation, i.e. latent self-conditioning. RINs yield state-of-the-art pixel diffusion models for image and video generation, scaling to 1024X1024 images without cascades or guidance, while being domain-agnostic and up to 10X more efficient than 2D and 3D U-Nets.

Shekoofeh Azizi, Laura Culp, Jan Freyberg et al.

Recent progress in Medical Artificial Intelligence (AI) has delivered systems that can reach clinical expert level performance. However, such systems tend to demonstrate sub-optimal "out-of-distribution" performance when evaluated in clinical settings different from the training environment. A common mitigation strategy is to develop separate systems for each clinical setting using site-specific data [1]. However, this quickly becomes impractical as medical data is time-consuming to acquire and expensive to annotate [2]. Thus, the problem of "data-efficient generalization" presents an ongoing difficulty for Medical AI development. Although progress in representation learning shows promise, their benefits have not been rigorously studied, specifically for out-of-distribution settings. To meet these challenges, we present REMEDIS, a unified representation learning strategy to improve robustness and data-efficiency of medical imaging AI. REMEDIS uses a generic combination of large-scale supervised transfer learning with self-supervised learning and requires little task-specific customization. We study a diverse range of medical imaging tasks and simulate three realistic application scenarios using retrospective data. REMEDIS exhibits significantly improved in-distribution performance with up to 11.5% relative improvement in diagnostic accuracy over a strong supervised baseline. More importantly, our strategy leads to strong data-efficient generalization of medical imaging AI, matching strong supervised baselines using between 1% to 33% of retraining data across tasks. These results suggest that REMEDIS can significantly accelerate the life-cycle of medical imaging AI development thereby presenting an important step forward for medical imaging AI to deliver broad impact.

Tao Gao, Yuanbo Wen, Kaihao Zhang et al.

Rain-by-snow weather removal is a specialized task in weather-degraded image restoration aiming to eliminate coexisting rain streaks and snow particles. In this paper, we propose RSFormer, an efficient and effective Transformer that addresses this challenge. Initially, we explore the proximity of convolution networks (ConvNets) and vision Transformers (ViTs) in hierarchical architectures and experimentally find they perform approximately at intra-stage feature learning. On this basis, we utilize a Transformer-like convolution block (TCB) that replaces the computationally expensive self-attention while preserving attention characteristics for adapting to input content. We also demonstrate that cross-stage progression is critical for performance improvement, and propose a global-local self-attention sampling mechanism (GLASM) that down-/up-samples features while capturing both global and local dependencies. Finally, we synthesize two novel rain-by-snow datasets, RSCityScape and RS100K, to evaluate our proposed RSFormer. Extensive experiments verify that RSFormer achieves the best trade-off between performance and time-consumption compared to other restoration methods. For instance, it outperforms Restormer with a 1.53% reduction in the number of parameters and a 15.6% reduction in inference time. Datasets, source code and pre-trained models are available at \url{https://github.com/chdwyb/RSFormer}.

Emmanuel Brempong Asiedu, Simon Kornblith, Ting Chen et al.

Semantic segmentation labels are expensive and time consuming to acquire. Hence, pretraining is commonly used to improve the label-efficiency of segmentation models. Typically, the encoder of a segmentation model is pretrained as a classifier and the decoder is randomly initialized. Here, we argue that random initialization of the decoder can be suboptimal, especially when few labeled examples are available. We propose a decoder pretraining approach based on denoising, which can be combined with supervised pretraining of the encoder. We find that decoder denoising pretraining on the ImageNet dataset strongly outperforms encoder-only supervised pretraining. Despite its simplicity, decoder denoising pretraining achieves state-of-the-art results on label-efficient semantic segmentation and offers considerable gains on the Cityscapes, Pascal Context, and ADE20K datasets.

Yuanbo Wen, Tao Gao, Ziqi Li et al.

Eliminating the rain degradation in stereo images poses a formidable challenge, which necessitates the efficient exploitation of mutual information present between the dual views. To this end, we devise MQINet, which employs multi-dimension queries and interactions for stereo image deraining. More specifically, our approach incorporates a context-aware dimension-wise queried block (CDQB). This module leverages dimension-wise queries that are independent of the input features and employs global context-aware attention (GCA) to capture essential features while avoiding the entanglement of redundant or irrelevant information. Meanwhile, we introduce an intra-view physics-aware attention (IPA) based on the inverse physical model of rainy images. IPA extracts shallow features that are sensitive to the physics of rain degradation, facilitating the reduction of rain-related artifacts during the early learning period. Furthermore, we integrate a cross-view multi-dimension interacting attention mechanism (CMIA) to foster comprehensive feature interaction between the two views across multiple dimensions. Extensive experimental evaluations demonstrate the superiority of our model over EPRRNet and StereoIRR, achieving respective improvements of 4.18 dB and 0.45 dB in PSNR. Code and models are available at \url{https://github.com/chdwyb/MQINet}.

Xuan Zhang, Shiyu Li, Xi Li et al.

Visual anomaly detection, an important problem in computer vision, is usually formulated as a one-class classification and segmentation task. The student-teacher (S-T) framework has proved to be effective in solving this challenge. However, previous works based on S-T only empirically applied constraints on normal data and fused multi-level information. In this study, we propose an improved model called DeSTSeg, which integrates a pre-trained teacher network, a denoising student encoder-decoder, and a segmentation network into one framework. First, to strengthen the constraints on anomalous data, we introduce a denoising procedure that allows the student network to learn more robust representations. From synthetically corrupted normal images, we train the student network to match the teacher network feature of the same images without corruption. Second, to fuse the multi-level S-T features adaptively, we train a segmentation network with rich supervision from synthetic anomaly masks, achieving a substantial performance improvement. Experiments on the industrial inspection benchmark dataset demonstrate that our method achieves state-of-the-art performance, 98.6% on image-level AUC, 75.8% on pixel-level average precision, and 76.4% on instance-level average precision.

Ting Chen

We empirically study the effect of noise scheduling strategies for denoising diffusion generative models. There are three findings: (1) the noise scheduling is crucial for the performance, and the optimal one depends on the task (e.g., image sizes), (2) when increasing the image size, the optimal noise scheduling shifts towards a noisier one (due to increased redundancy in pixels), and (3) simply scaling the input data by a factor of $b$ while keeping the noise schedule function fixed (equivalent to shifting the logSNR by $\log b$) is a good strategy across image sizes. This simple recipe, when combined with recently proposed Recurrent Interface Network (RIN), yields state-of-the-art pixel-based diffusion models for high-resolution images on ImageNet, enabling single-stage, end-to-end generation of diverse and high-fidelity images at 1024$\times$1024 resolution (without upsampling/cascades).

Ting Chen, Geng Li, Guohao Chen et al.

Contrastive decoding (CD) seeks to mitigate hallucinations in Large Vision-Language Models (LVLMs) by contrasting the output distributions of a standard model and a visually degraded model. However, existing training-free CD methods suffer from sub-optimal degraded branches: completely dropping visual tokens is too extreme and induces language hallucinations, while corrupting input images offers coarse control over visual evidence and suffers from high inference latency due to requiring two full forward passes. To address these dilemmas, we propose YARD, a training-free Y-Architecture Register Decoding framework. Motivated by the observation that reliable text-to-vision grounding predominantly emerges in the middle decoder layers, YARD constructs the degraded branch internally by sharing shallow-layer computations and branching exactly at this critical stage. For the degraded branch, YARD replaces patch-level visual tokens with register tokens, which preserve global image semantics but lack fine-grained local evidence. This image-aware yet locally under-grounded design provides a faithful contrastive signal without extreme modality mismatch, while the Y-architecture strictly avoids a costly second forward pass. Extensive experiments on generative and discriminative hallucination benchmarks demonstrate that YARD consistently achieves state-of-the-art hallucination mitigation across multiple LVLMs, alongside a significant reduction in inference latency.

Geng Li, Guohao Chen, Ting Chen et al.

Vision-language models (VLMs) rely on long visual token sequences for visual understanding, making the prefill stage expensive in both computation and memory. Most existing pruning methods follow an absolute-ranking paradigm, assigning importance scores to visual tokens and retaining a fixed top-K subset. In this work, we argue that this paradigm is fundamentally brittle: attention sinks distort token importance rankings, while image redundancy and query-dependent visual evidence make fixed token budgets unreliable across inputs. We propose OccamToken, a training-free framework that replaces absolute token ranking with register-anchored relative evidence testing. Instead of asking which tokens are globally important, OccamToken evaluates whether a visual token provides information beyond a register-based reference. Our key insight is that register tokens naturally absorb low-information attention patterns, making them a stable reference for identifying genuinely informative visual evidence. Based on this principle, OccamToken performs both image-adaptive redundancy pruning and query-adaptive relevance pruning through dynamic thresholds derived from register attention. Across LLaVA-NeXT, LLaVA-v1.5, and Qwen3-VL, OccamToken consistently improves the accuracy-efficiency trade-off without additional training. Notably, on LLaVA-NeXT, it reduces 2,880 visual tokens to approximately 40 while preserving over 93% of the original accuracy, enabling stable visual token compression even in the extreme 1.4% retention regime.

Jiachi Chen, Qingyuan Zhong, Yanlin Wang et al.

The emergence of Large Language Models (LLMs) has significantly influenced various aspects of software development activities. Despite their benefits, LLMs also pose notable risks, including the potential to generate harmful content and being abused by malicious developers to create malicious code. Several previous studies have focused on the ability of LLMs to resist the generation of harmful content that violates human ethical standards, such as biased or offensive content. However, there is no research evaluating the ability of LLMs to resist malicious code generation. To fill this gap, we propose RMCBench, the first benchmark comprising 473 prompts designed to assess the ability of LLMs to resist malicious code generation. This benchmark employs two scenarios: a text-to-code scenario, where LLMs are prompted with descriptions to generate code, and a code-to-code scenario, where LLMs translate or complete existing malicious code. Based on RMCBench, we conduct an empirical study on 11 representative LLMs to assess their ability to resist malicious code generation. Our findings indicate that current LLMs have a limited ability to resist malicious code generation with an average refusal rate of 40.36% in text-to-code scenario and 11.52% in code-to-code scenario. The average refusal rate of all LLMs in RMCBench is only 28.71%; ChatGPT-4 has a refusal rate of only 35.73%. We also analyze the factors that affect LLMs' ability to resist malicious code generation and provide implications for developers to enhance model robustness.

Wentse Chen, Shiyu Huang, Yuan Chiang et al.

Most reinforcement learning algorithms seek a single optimal strategy that solves a given task. However, it can often be valuable to learn a diverse set of solutions, for instance, to make an agent's interaction with users more engaging, or improve the robustness of a policy to an unexpected perturbance. We propose Diversity-Guided Policy Optimization (DGPO), an on-policy algorithm that discovers multiple strategies for solving a given task. Unlike prior work, it achieves this with a shared policy network trained over a single run. Specifically, we design an intrinsic reward based on an information-theoretic diversity objective. Our final objective alternately constraints on the diversity of the strategies and on the extrinsic reward. We solve the constrained optimization problem by casting it as a probabilistic inference task and use policy iteration to maximize the derived lower bound. Experimental results show that our method efficiently discovers diverse strategies in a wide variety of reinforcement learning tasks. Compared to baseline methods, DGPO achieves comparable rewards, while discovering more diverse strategies, and often with better sample efficiency.

Rong Han, Xiaohong Liu, Tong Pan et al.

Accurately measuring protein-RNA binding affinity is crucial in many biological processes and drug design. Previous computational methods for protein-RNA binding affinity prediction rely on either sequence or structure features, unable to capture the binding mechanisms comprehensively. The recent emerging pre-trained language models trained on massive unsupervised sequences of protein and RNA have shown strong representation ability for various in-domain downstream tasks, including binding site prediction. However, applying different-domain language models collaboratively for complex-level tasks remains unexplored. In this paper, we propose CoPRA to bridge pre-trained language models from different biological domains via Complex structure for Protein-RNA binding Affinity prediction. We demonstrate for the first time that cross-biological modal language models can collaborate to improve binding affinity prediction. We propose a Co-Former to combine the cross-modal sequence and structure information and a bi-scope pre-training strategy for improving Co-Former's interaction understanding. Meanwhile, we build the largest protein-RNA binding affinity dataset PRA310 for performance evaluation. We also test our model on a public dataset for mutation effect prediction. CoPRA reaches state-of-the-art performance on all the datasets. We provide extensive analyses and verify that CoPRA can (1) accurately predict the protein-RNA binding affinity; (2) understand the binding affinity change caused by mutations; and (3) benefit from scaling data and model size.

Yuanbo Wen, Tao Gao, Ting Chen

Existing unpaired image deraining approaches face challenges in accurately capture the distinguishing characteristics between the rainy and clean domains, resulting in residual degradation and color distortion within the reconstructed images. To this end, we propose an energy-informed diffusion model for unpaired photo-realistic image deraining (UPID-EDM). Initially, we delve into the intricate visual-language priors embedded within the contrastive language-image pre-training model (CLIP), and demonstrate that the CLIP priors aid in the discrimination of rainy and clean images. Furthermore, we introduce a dual-consistent energy function (DEF) that retains the rain-irrelevant characteristics while eliminating the rain-relevant features. This energy function is trained by the non-corresponding rainy and clean images. In addition, we employ the rain-relevance discarding energy function (RDEF) and the rain-irrelevance preserving energy function (RPEF) to direct the reverse sampling procedure of a pre-trained diffusion model, effectively removing the rain streaks while preserving the image contents. Extensive experiments demonstrate that our energy-informed model surpasses the existing unpaired learning approaches in terms of both supervised and no-reference metrics.

Xuanzhong Chen, Xiaohao Mao, Qihan Guo et al.

Generalist Large Language Models (LLMs), such as GPT-4, have shown considerable promise in various domains, including medical diagnosis. Rare diseases, affecting approximately 300 million people worldwide, often have unsatisfactory clinical diagnosis rates primarily due to a lack of experienced physicians and the complexity of differentiating among many rare diseases. In this context, recent news such as "ChatGPT correctly diagnosed a 4-year-old's rare disease after 17 doctors failed" underscore LLMs' potential, yet underexplored, role in clinically diagnosing rare diseases. To bridge this research gap, we introduce RareBench, a pioneering benchmark designed to systematically evaluate the capabilities of LLMs on 4 critical dimensions within the realm of rare diseases. Meanwhile, we have compiled the largest open-source dataset on rare disease patients, establishing a benchmark for future studies in this domain. To facilitate differential diagnosis of rare diseases, we develop a dynamic few-shot prompt methodology, leveraging a comprehensive rare disease knowledge graph synthesized from multiple knowledge bases, significantly enhancing LLMs' diagnostic performance. Moreover, we present an exhaustive comparative study of GPT-4's diagnostic capabilities against those of specialist physicians. Our experimental findings underscore the promising potential of integrating LLMs into the clinical diagnostic process for rare diseases. This paves the way for exciting possibilities in future advancements in this field.

Wenkai Li, Cheng Feng, Ting Chen et al.

Time series anomaly detection (TSAD) is an important data mining task with numerous applications in the IoT era. In recent years, a large number of deep neural network-based methods have been proposed, demonstrating significantly better performance than conventional methods on addressing challenging TSAD problems in a variety of areas. Nevertheless, these deep TSAD methods typically rely on a clean training dataset that is not polluted by anomalies to learn the "normal profile" of the underlying dynamics. This requirement is nontrivial since a clean dataset can hardly be provided in practice. Moreover, without the awareness of their robustness, blindly applying deep TSAD methods with potentially contaminated training data can possibly incur significant performance degradation in the detection phase. In this work, to tackle this important challenge, we firstly investigate the robustness of commonly used deep TSAD methods with contaminated training data which provides a guideline for applying these methods when the provided training data are not guaranteed to be anomaly-free. Furthermore, we propose a model-agnostic method which can effectively improve the robustness of learning mainstream deep TSAD models with potentially contaminated data. Experiment results show that our method can consistently prevent or mitigate performance degradation of mainstream deep TSAD models on widely used benchmark datasets.

Lingxiao Luo, Bingda Tang, Xuanzhong Chen et al.

Recent advancements in Vision Language Models (VLMs) have demonstrated remarkable promise in generating visually grounded responses. However, their application in the medical domain is hindered by unique challenges. For instance, most VLMs rely on a single method of visual grounding, whereas complex medical tasks demand more versatile approaches. Additionally, while most VLMs process only 2D images, a large portion of medical images are 3D. The lack of medical data further compounds these obstacles. To address these challenges, we present VividMed, a vision language model with versatile visual grounding for medicine. Our model supports generating both semantic segmentation masks and instance-level bounding boxes, and accommodates various imaging modalities, including both 2D and 3D data. We design a three-stage training procedure and an automatic data synthesis pipeline based on open datasets and models. Besides visual grounding tasks, VividMed also excels in other common downstream tasks, including Visual Question Answering (VQA) and report generation. Ablation studies empirically show that the integration of visual grounding ability leads to improved performance on these tasks. Our code is publicly available at https://github.com/function2-llx/MMMM.

Yuanbo Wen, Tao Gao, Ziqi Li et al.

Haze obscures remote sensing images, hindering valuable information extraction. To this end, we propose RSHazeNet, an encoder-minimal and decoder-minimal framework for efficient remote sensing image dehazing. Specifically, regarding the process of merging features within the same level, we develop an innovative module called intra-level transposed fusion module (ITFM). This module employs adaptive transposed self-attention to capture comprehensive context-aware information, facilitating the robust context-aware feature fusion. Meanwhile, we present a cross-level multi-view interaction module (CMIM) to enable effective interactions between features from various levels, mitigating the loss of information due to the repeated sampling operations. In addition, we propose a multi-view progressive extraction block (MPEB) that partitions the features into four distinct components and employs convolution with varying kernel sizes, groups, and dilation factors to facilitate view-progressive feature learning. Extensive experiments demonstrate the superiority of our proposed RSHazeNet. We release the source code and all pre-trained models at \url{https://github.com/chdwyb/RSHazeNet}.

Kalvin Chang, Nathaniel R. Robinson, Anna Cai et al. · cmu

We describe a set of new methods to partially automate linguistic phylogenetic inference given (1) cognate sets with their respective protoforms and sound laws, (2) a mapping from phones to their articulatory features and (3) a typological database of sound changes. We train a neural network on these sound change data to weight articulatory distances between phones and predict intermediate sound change steps between historical protoforms and their modern descendants, replacing a linguistic expert in part of a parsimony-based phylogenetic inference algorithm. In our best experiments on Tukanoan languages, this method produces trees with a Generalized Quartet Distance of 0.12 from a tree that used expert annotations, a significant improvement over other semi-automated baselines. We discuss potential benefits and drawbacks to our neural approach and parsimony-based tree prediction. We also experiment with a minimal generalization learner for automatic sound law induction, finding it comparably effective to sound laws from expert annotation. Our code is publicly available at https://github.com/cmu-llab/aiscp.

Lingxiao Luo, Xuanzhong Chen, Bingda Tang et al.

Recent advancements in foundation models, typically trained with self-supervised learning on large-scale and diverse datasets, have shown great potential in medical image analysis. However, due to the significant spatial heterogeneity of medical imaging data, current models must tailor specific structures for different datasets, making it challenging to leverage the abundant unlabeled data. In this work, we propose a universal foundation model for medical image analysis that processes images with heterogeneous spatial properties using a unified structure. To accomplish this, we propose spatially adaptive networks (SPAD-Nets), a family of networks that dynamically adjust the structures to adapt to the spatial properties of input images, to build such a universal foundation model. We pre-train a spatial adaptive visual tokenizer (SPAD-VT) and then a spatial adaptive Vision Transformer (SPAD-ViT) via masked image modeling (MIM) on 55 public medical image datasets. The pre-training data comprises over 9 million image slices, representing the largest, most comprehensive, and most diverse dataset to our knowledge for pre-training universal foundation models for medical image analysis. The experimental results on downstream medical image classification and segmentation tasks demonstrate the superior performance and label efficiency of our model. Our code is available at https://github.com/function2-llx/PUMIT.

Weijie He, Ting Chen

For those seeking healthcare advice online, AI based dialogue agents capable of interacting with patients to perform automatic disease diagnosis are a viable option. This application necessitates efficient inquiry of relevant disease symptoms in order to make accurate diagnosis recommendations. This can be formulated as a problem of sequential feature (symptom) selection and classification for which reinforcement learning (RL) approaches have been proposed as a natural solution. They perform well when the feature space is small, that is, the number of symptoms and diagnosable disease categories is limited, but they frequently fail in assignments with a large number of features. To address this challenge, we propose a Multi-Model-Fused Actor-Critic (MMF-AC) RL framework that consists of a generative actor network and a diagnostic critic network. The actor incorporates a Variational AutoEncoder (VAE) to model the uncertainty induced by partial observations of features, thereby facilitating in making appropriate inquiries. In the critic network, a supervised diagnosis model for disease predictions is involved to precisely estimate the state-value function. Furthermore, inspired by the medical concept of differential diagnosis, we combine the generative and diagnosis models to create a novel reward shaping mechanism to address the sparse reward problem in large search spaces. We conduct extensive experiments on both synthetic and real-world datasets for empirical evaluations. The results demonstrate that our approach outperforms state-of-the-art methods in terms of diagnostic accuracy and interaction efficiency while also being more effectively scalable to large search spaces. Besides, our method is adaptable to both categorical and continuous features, making it ideal for online applications.

Zhiwei Deng, Ting Chen, Yang Li

Human visual recognition system shows astonishing capability of compressing visual information into a set of tokens containing rich representations without label supervision. One critical driving principle behind it is perceptual grouping. Despite being widely used in computer vision in the early 2010s, it remains a mystery whether perceptual grouping can be leveraged to derive a neural visual recognition backbone that generates as powerful representations. In this paper, we propose the Perceptual Group Tokenizer, a model that entirely relies on grouping operations to extract visual features and perform self-supervised representation learning, where a series of grouping operations are used to iteratively hypothesize the context for pixels or superpixels to refine feature representations. We show that the proposed model can achieve competitive performance compared to state-of-the-art vision architectures, and inherits desirable properties including adaptive computation without re-training, and interpretability. Specifically, Perceptual Group Tokenizer achieves 80.3% on ImageNet-1K self-supervised learning benchmark with linear probe evaluation, marking a new progress under this paradigm.

Emaad Khwaja, Abdullah Rashwan, Ting Chen et al.

We present a one-shot text-to-image diffusion model that can generate high-resolution images from natural language descriptions. Our model employs a layered U-Net architecture that simultaneously synthesizes images at multiple resolution scales. We show that this method outperforms the baseline of synthesizing images only at the target resolution, while reducing the computational cost per step. We demonstrate that higher resolution synthesis can be achieved by layering convolutions at additional resolution scales, in contrast to other methods which require additional models for super-resolution synthesis.

Calvin Luo, Boqing Gong, Ting Chen et al.

Recognition and reasoning are two pillars of visual understanding. However, these tasks have an imbalance in focus; whereas recent advances in neural networks have shown strong empirical performance in visual recognition, there has been comparably much less success in solving visual reasoning. Intuitively, unifying these two tasks under a singular framework is desirable, as they are mutually dependent and beneficial. Motivated by the recent success of multi-task transformers for visual recognition and language understanding, we propose a unified neural architecture for visual recognition and reasoning with a generic interface (e.g., tokens) for both. Our framework enables the principled investigation of how different visual recognition tasks, datasets, and inductive biases can help enable spatiotemporal reasoning capabilities. Noticeably, we find that object detection, which requires spatial localization of individual objects, is the most beneficial recognition task for reasoning. We further demonstrate via probing that implicit object-centric representations emerge automatically inside our framework. Intriguingly, we discover that certain architectural choices such as the backbone model of the visual encoder have a significant impact on visual reasoning, but little on object detection. Given the results of our experiments, we believe that visual reasoning should be considered as a first-class citizen alongside visual recognition, as they are strongly correlated but benefit from potentially different design choices.

Shikuang Deng, Jiayuan Zhang, Yuhang Wu et al.

Hebbian learning is a biological principle that intuitively describes how neurons adapt their connections through repeated stimuli. However, when applied to machine learning, it suffers serious issues due to the unconstrained updates of the connections and the lack of accounting for feedback mediation. Such shortcomings limit its effective scaling to complex network architectures and tasks. To this end, here we introduce the Structural Projection Hebbian Representation (SPHeRe), a novel unsupervised learning method that integrates orthogonality and structural information preservation through a local auxiliary nonlinear block. The loss for structural information preservation backpropagates to the input through an auxiliary lightweight projection that conceptually serves as feedback mediation while the orthogonality constraints account for the boundedness of updating magnitude. Extensive experimental results show that SPHeRe achieves SOTA performance among unsupervised synaptic plasticity approaches on standard image classification benchmarks, including CIFAR-10, CIFAR-100, and Tiny-ImageNet. Furthermore, the method exhibits strong effectiveness in continual learning and transfer learning scenarios, and image reconstruction tasks show the robustness and generalizability of the extracted features. This work demonstrates the competitiveness and potential of Hebbian unsupervised learning rules within modern deep learning frameworks, demonstrating the possibility of efficient and biologically inspired learning algorithms without the strong dependence on strict backpropagation. Our code is available at https://github.com/brain-intelligence-lab/SPHeRe.

Ziyu Jiang, Tianlong Chen, Ting Chen et al.

Contrastive learning approaches have achieved great success in learning visual representations with few labels of the target classes. That implies a tantalizing possibility of scaling them up beyond a curated "seed" benchmark, to incorporating more unlabeled images from the internet-scale external sources to enhance its performance. However, in practice, larger amount of unlabeled data will require more computing resources due to the bigger model size and longer training needed. Moreover, open-world unlabeled data usually follows an implicit long-tail class or attribute distribution, many of which also do not belong to the target classes. Blindly leveraging all unlabeled data hence can lead to the data imbalance as well as distraction issues. This motivates us to seek a principled approach to strategically select unlabeled data from an external source, in order to learn generalizable, balanced and diverse representations for relevant classes. In this work, we present an open-world unlabeled data sampling framework called Model-Aware K-center (MAK), which follows three simple principles: (1) tailness, which encourages sampling of examples from tail classes, by sorting the empirical contrastive loss expectation (ECLE) of samples over random data augmentations; (2) proximity, which rejects the out-of-distribution outliers that may distract training; and (3) diversity, which ensures diversity in the set of sampled examples. Empirically, using ImageNet-100-LT (without labels) as the seed dataset and two "noisy" external data sources, we demonstrate that MAK can consistently improve both the overall representation quality and the class balancedness of the learned features, as evaluated via linear classifier evaluation on full-shot and few-shot settings. The code is available at: https://github.com/VITA-Group/MAK

Long Zhao, Zizhao Zhang, Ting Chen et al.

Attention-based models, exemplified by the Transformer, can effectively model long range dependency, but suffer from the quadratic complexity of self-attention operation, making them difficult to be adopted for high-resolution image generation based on Generative Adversarial Networks (GANs). In this paper, we introduce two key ingredients to Transformer to address this challenge. First, in low-resolution stages of the generative process, standard global self-attention is replaced with the proposed multi-axis blocked self-attention which allows efficient mixing of local and global attention. Second, in high-resolution stages, we drop self-attention while only keeping multi-layer perceptrons reminiscent of the implicit neural function. To further improve the performance, we introduce an additional self-modulation component based on cross-attention. The resulting model, denoted as HiT, has a nearly linear computational complexity with respect to the image size and thus directly scales to synthesizing high definition images. We show in the experiments that the proposed HiT achieves state-of-the-art FID scores of 30.83 and 2.95 on unconditional ImageNet $128 \times 128$ and FFHQ $256 \times 256$, respectively, with a reasonable throughput. We believe the proposed HiT is an important milestone for generators in GANs which are completely free of convolutions. Our code is made publicly available at https://github.com/google-research/hit-gan

Zizhao Zhang, Han Zhang, Long Zhao et al.

Hierarchical structures are popular in recent vision transformers, however, they require sophisticated designs and massive datasets to work well. In this paper, we explore the idea of nesting basic local transformers on non-overlapping image blocks and aggregating them in a hierarchical way. We find that the block aggregation function plays a critical role in enabling cross-block non-local information communication. This observation leads us to design a simplified architecture that requires minor code changes upon the original vision transformer. The benefits of the proposed judiciously-selected design are threefold: (1) NesT converges faster and requires much less training data to achieve good generalization on both ImageNet and small datasets like CIFAR; (2) when extending our key ideas to image generation, NesT leads to a strong decoder that is 8$\times$ faster than previous transformer-based generators; and (3) we show that decoupling the feature learning and abstraction processes via this nested hierarchy in our design enables constructing a novel method (named GradCAT) for visually interpreting the learned model. Source code is available https://github.com/google-research/nested-transformer.

Nikolay Ivanov, Jianzhi Lou, Ting Chen et al.

Ethereum holds multiple billions of U.S. dollars in the form of Ether cryptocurrency and ERC-20 tokens, with millions of deployed smart contracts algorithmically operating these funds. Unsurprisingly, the security of Ethereum smart contracts has been under rigorous scrutiny. In recent years, numerous defense tools have been developed to detect different types of smart contract code vulnerabilities. When opportunities for exploiting code vulnerabilities diminish, the attackers start resorting to social engineering attacks, which aim to influence humans -- often the weakest link in the system. The only known class of social engineering attacks in Ethereum are honeypots, which plant hidden traps for attackers attempting to exploit existing vulnerabilities, thereby targeting only a small population of potential victims. In this work, we explore the possibility and existence of new social engineering attacks beyond smart contract honeypots. We present two novel classes of Ethereum social engineering attacks - Address Manipulation and Homograph - and develop six zero-day social engineering attacks. To show how the attacks can be used in popular programming patterns, we conduct a case study of five popular smart contracts with combined market capitalization exceeding $29 billion, and integrate our attack patterns in their source codes without altering their existing functionality. Moreover, we show that these attacks remain dormant during the test phase but activate their malicious logic only at the final production deployment. We further analyze 85,656 open-source smart contracts, and discover that 1,027 of them can be used for the proposed social engineering attacks. We conduct a professional opinion survey with experts from seven smart contract auditing firms, corroborating that the exposed social engineering attacks bring a major threat to the smart contract systems.

Ziyu Jiang, Tianlong Chen, Ting Chen et al.

Recent work has shown that, when integrated with adversarial training, self-supervised pre-training can lead to state-of-the-art robustness In this work, we improve robustness-aware self-supervised pre-training by learning representations that are consistent under both data augmentations and adversarial perturbations. Our approach leverages a recent contrastive learning framework, which learns representations by maximizing feature consistency under differently augmented views. This fits particularly well with the goal of adversarial robustness, as one cause of adversarial fragility is the lack of feature invariance, i.e., small input perturbations can result in undesirable large changes in features or even predicted labels. We explore various options to formulate the contrastive task, and demonstrate that by injecting adversarial perturbations, contrastive pre-training can lead to models that are both label-efficient and robust. We empirically evaluate the proposed Adversarial Contrastive Learning (ACL) and show it can consistently outperform existing methods. For example on the CIFAR-10 dataset, ACL outperforms the previous state-of-the-art unsupervised robust pre-training approach by 2.99% on robust accuracy and 2.14% on standard accuracy. We further demonstrate that ACL pre-training can improve semi-supervised adversarial training, even when only a few labeled examples are available. Our codes and pre-trained models have been released at: https://github.com/VITA-Group/Adversarial-Contrastive-Learning.

Yuning You, Tianlong Chen, Yongduo Sui et al.

Generalizable, transferrable, and robust representation learning on graph-structured data remains a challenge for current graph neural networks (GNNs). Unlike what has been developed for convolutional neural networks (CNNs) for image data, self-supervised learning and pre-training are less explored for GNNs. In this paper, we propose a graph contrastive learning (GraphCL) framework for learning unsupervised representations of graph data. We first design four types of graph augmentations to incorporate various priors. We then systematically study the impact of various combinations of graph augmentations on multiple datasets, in four different settings: semi-supervised, unsupervised, and transfer learning as well as adversarial attacks. The results show that, even without tuning augmentation extents nor using sophisticated GNN architectures, our GraphCL framework can produce graph representations of similar or better generalizability, transferrability, and robustness compared to state-of-the-art methods. We also investigate the impact of parameterized graph augmentation extents and patterns, and observe further performance gains in preliminary experiments. Our codes are available at https://github.com/Shen-Lab/GraphCL.

Jiachi Chen, Xin Xia, David Lo et al.

Smart contracts are Turing-complete programs running on the blockchain. They are immutable and cannot be modified, even when bugs are detected. Therefore, ensuring smart contracts are bug-free and well-designed before deploying them to the blockchain is extremely important. A contract defect is an error, flaw or fault in a smart contract that causes it to produce an incorrect or unexpected result, or to behave in unintended ways. Detecting and removing contract defects can avoid potential bugs and make programs more robust. Our previous work defined 20 contract defects for smart contracts and divided them into five impact levels. According to our classification, contract defects with seriousness level between 1-3 can lead to unwanted behaviors, e.g., a contract being controlled by attackers. In this paper, we propose DefectChecker, a symbolic execution-based approach and tool to detect eight contract defects that can cause unwanted behaviors of smart contracts on the Ethereum blockchain platform. DefectChecker can detect contract defects from smart contracts bytecode. We compare DefectChecker with key previous works, including Oyente, Mythril and Securify by using an open-source dataset. Our experimental results show that DefectChecker performs much better than these tools in terms of both speed and accuracy. We also applied DefectChecker to 165,621 distinct smart contracts on the Ethereum platform. We found that 25,815 of these smart contracts contain at least one of the contract defects that belongs to impact level 1-3, including some real-world attacks.

Xiaoqi Li, Ting Chen, Xiapu Luo et al.

More than eight million smart contracts have been deployed into Ethereum, which is the most popular blockchain that supports smart contract. However, less than 1% of deployed smart contracts are open-source, and it is difficult for users to understand the functionality and internal mechanism of those closed-source contracts. Although a few decompilers for smart contracts have been recently proposed, it is still not easy for users to grasp the semantic information of the contract, not to mention the potential misleading due to decompilation errors. In this paper, we propose the first system named STAN to generate descriptions for the bytecodes of smart contracts to help users comprehend them. In particular, for each interface in a smart contract, STAN can generate four categories of descriptions, including functionality description, usage description, behavior description, and payment description, by leveraging symbolic execution and NLP (Natural Language Processing) techniques. Extensive experiments show that STAN can generate adequate, accurate, and readable descriptions for contract's bytecodes, which have practical value for users.

Dongming Wu, Junwen Li, Ming Lu et al.

Transforming fragmented enterprise data into actionable insights remains a significant challenge for LLMs, constrained by complex database schemas, limitations in dynamic SQL generation, and the need for deep multi-dimensional analysis.In this paper, we propose AIDA(Autonomous Insight Discovery Agent), the first end-to-end framework designed for autonomous exploration in complex business environments. We establish a highly flexible instant retail environment encompassing 200+ metrics and 100+ dimensions, and integrates a proprietary Domain-Specific Language (DSL) that bridges semantic reasoning with precise SQL execution. Our reinforcement learning system subsequently formulates business analysis as a Pareto Principle-guided cumulative reasoning process. Experimental results demonstrate that AIDA significantly outperforms workflow-based agents, and extensive evaluations further reveal that AIDA achieves superior environmental perception and more in-depth analysis from diverse perspectives. Our work ultimately establishes the transformative potential of autonomous intelligence for industrial-scale business intelligence systems.

Yuanbo Wen, Tao Gao, Ziqi Li et al.

Existing approaches for all-in-one weather-degraded image restoration suffer from inefficiencies in leveraging degradation-aware priors, resulting in sub-optimal performance in adapting to different weather conditions. To this end, we develop an adaptive degradation-aware self-prompting model (ADSM) for all-in-one weather-degraded image restoration. Specifically, our model employs the contrastive language-image pre-training model (CLIP) to facilitate the training of our proposed latent prompt generators (LPGs), which represent three types of latent prompts to characterize the degradation type, degradation property and image caption. Moreover, we integrate the acquired degradation-aware prompts into the time embedding of diffusion model to improve degradation perception. Meanwhile, we employ the latent caption prompt to guide the reverse sampling process using the cross-attention mechanism, thereby guiding the accurate image reconstruction. Furthermore, to accelerate the reverse sampling procedure of diffusion model and address the limitations of frequency perception, we introduce a wavelet-oriented noise estimating network (WNE-Net). Extensive experiments conducted on eight publicly available datasets demonstrate the effectiveness of our proposed approach in both task-specific and all-in-one applications.

Yazhe Li, Jorg Bornschein, Ting Chen

In this paper, we explore a new generative approach for learning visual representations. Our method, DARL, employs a decoder-only Transformer to predict image patches autoregressively. We find that training with Mean Squared Error (MSE) alone leads to strong representations. To enhance the image generation ability, we replace the MSE loss with the diffusion objective by using a denoising patch decoder. We show that the learned representation can be improved by using tailored noise schedules and longer training in larger models. Notably, the optimal schedule differs significantly from the typical ones used in standard image diffusion models. Overall, despite its simple architecture, DARL delivers performance remarkably close to state-of-the-art masked prediction models under the fine-tuning protocol. This marks an important step towards a unified model capable of both visual perception and generation, effectively combining the strengths of autoregressive and denoising diffusion models.

Xuanzhong Chen, Ye Jin, Xiaohao Mao et al.

Rare diseases, despite their low individual incidence, collectively impact around 300 million people worldwide due to the vast number of diseases. The involvement of multiple organs and systems, and the shortage of specialized doctors with relevant experience, make diagnosing and treating rare diseases more challenging than common diseases. Recently, agents powered by large language models (LLMs) have demonstrated notable applications across various domains. In the medical field, some agent methods have outperformed direct prompts in question-answering tasks from medical examinations. However, current agent frameworks are not well-adapted to real-world clinical scenarios, especially those involving the complex demands of rare diseases. To bridge this gap, we introduce RareAgents, the first LLM-driven multi-disciplinary team decision-support tool designed specifically for the complex clinical context of rare diseases. RareAgents integrates advanced Multidisciplinary Team (MDT) coordination, memory mechanisms, and medical tools utilization, leveraging Llama-3.1-8B/70B as the base model. Experimental results show that RareAgents outperforms state-of-the-art domain-specific models, GPT-4o, and current agent frameworks in diagnosis and treatment for rare diseases. Furthermore, we contribute a novel rare disease dataset, MIMIC-IV-Ext-Rare, to facilitate further research in this field.

Rong Han, Wenbing Huang, Lingxiao Luo et al.

Understanding and leveraging the 3D structures of proteins is central to a variety of biological and drug discovery tasks. While deep learning has been applied successfully for structure-based protein function prediction tasks, current methods usually employ distinct training for each task. However, each of the tasks is of small size, and such a single-task strategy hinders the models' performance and generalization ability. As some labeled 3D protein datasets are biologically related, combining multi-source datasets for larger-scale multi-task learning is one way to overcome this problem. In this paper, we propose a neural network model to address multiple tasks jointly upon the input of 3D protein structures. In particular, we first construct a standard structure-based multi-task benchmark called Protein-MT, consisting of 6 biologically relevant tasks, including affinity prediction and property prediction, integrated from 4 public datasets. Then, we develop a novel graph neural network for multi-task learning, dubbed Heterogeneous Multichannel Equivariant Network (HeMeNet), which is E(3) equivariant and able to capture heterogeneous relationships between different atoms. Besides, HeMeNet can achieve task-specific learning via the task-aware readout mechanism. Extensive evaluations on our benchmark verify the effectiveness of multi-task learning, and our model generally surpasses state-of-the-art models.

Xiaocheng Fang, Zhengyao Ding, Jieyi Cai et al.

Cardiac Magnetic Resonance (CMR) imaging provides a comprehensive assessment of cardiac structure and function but remains constrained by high acquisition costs and reliance on expert annotations, limiting the availability of large-scale labeled datasets. In contrast, electrocardiograms (ECGs) are inexpensive, widely accessible, and offer a promising modality for conditioning the generative synthesis of cine CMR. To this end, we propose ECGFlowCMR, a novel ECG-to-CMR generative framework that integrates a Phase-Aware Masked Autoencoder (PA-MAE) and an Anatomy-Motion Disentangled Flow (AMDF) to address two fundamental challenges: (1) the cross-modal temporal mismatch between multi-beat ECG recordings and single-cycle CMR sequences, and (2) the anatomical observability gap due to the limited structural information inherent in ECGs. Extensive experiments on the UK Biobank and a proprietary clinical dataset demonstrate that ECGFlowCMR can generate realistic cine CMR sequences from ECG inputs, enabling scalable pretraining and improving performance on downstream cardiac disease classification and phenotype prediction tasks.

Chong Chen, Ze Liu, Lingfeng Bao et al.

The cryptocurrency market offers significant investment opportunities but faces challenges including high volatility and fragmented information. Data integration and analysis are essential for informed investment decisions. Currently, investors use three main approaches: (1) Manual analysis across various sources, which depends heavily on individual experience and is time-consuming and prone to bias; (2) Data aggregation platforms-limited in functionality and depth of analysis; (3) Large language model agents-based on static pretrained models, lacking real-time data integration and multi-step reasoning capabilities. To address these limitations, we present Coinvisor, a reinforcement learning-based chatbot that provides comprehensive analytical support for cryptocurrency investment through a multi-agent framework. Coinvisor integrates diverse analytical capabilities through specialized tools. Its key innovation is a reinforcement learning-based tool selection mechanism that enables multi-step planning and flexible integration of diverse data sources. This design supports real-time interaction and adaptive analysis of dynamic content, delivering accurate and actionable investment insights. We evaluated Coinvisor through automated benchmarks on tool calling accuracy and user studies with 20 cryptocurrency investors using our interface. Results show that Coinvisor improves recall by 40.7% and F1 score by 26.6% over the base model in tool orchestration. User studies show high satisfaction (4.64/5), with participants preferring Coinvisor to both general LLMs and existing crypto platforms (4.62/5).

Yiming Shen, Jiashuo Zhang, Zhenzhe Shao et al.

The convergence of Web3 technologies and AI agents represents a rapidly evolving frontier poised to reshape decentralized ecosystems. This paper presents the first and most comprehensive analysis of the intersection between Web3 and AI agents, examining five critical dimensions: landscape, economics, governance, security, and trust mechanisms. Through an analysis of 133 existing projects, we first develop a taxonomy and systematically map the current market landscape (RQ1), identifying distinct patterns in project distribution and capitalization. Building upon these findings, we further investigate four key integrations: (1) the role of AI agents in participating in and optimizing decentralized finance (RQ2); (2) their contribution to enhancing Web3 governance mechanisms (RQ3); (3) their capacity to strengthen Web3 security via intelligent vulnerability detection and automated smart contract auditing (RQ4); and (4) the establishment of robust reliability frameworks for AI agent operations leveraging Web3's inherent trust infrastructure (RQ5). By synthesizing these dimensions, we identify key integration patterns, highlight foundational challenges related to scalability, security, and ethics, and outline critical considerations for future research toward building robust, intelligent, and trustworthy decentralized systems with effective AI agent interactions.

Hongming Tan, Ting Chen, Ruochong Jin et al.

Currently, iTransformer is one of the most popular and effective models for multivariate time series (MTS) forecasting. Thanks to its inverted framework, iTransformer effectively captures multivariate correlation. However, the inverted framework still has some limitations. It diminishes temporal interdependency information, and introduces noise in cases of nonsignificant variable correlation. To address these limitations, we introduce a novel data augmentation method on inverted framework, called DAIF. Unlike previous data augmentation methods, DAIF stands out as the first real-time augmentation specifically designed for the inverted framework in MTS forecasting. We first define the structure of the inverted sequence-to-sequence framework, then propose two different DAIF strategies, Frequency Filtering and Cross-variation Patching to address the existing challenges of the inverted framework. Experiments across multiple datasets and inverted models have demonstrated the effectiveness of our DAIF.

Yicong Wu, Ting Chen, Irit Hochberg et al.

Therapy recommendation for chronic patients with multimorbidity is challenging due to risks of treatment conflicts. Existing decision support systems face scalability limitations. Inspired by the way in which general practitioners (GP) manage multimorbidity patients, occasionally convening multidisciplinary team (MDT) collaboration, this study investigated the feasibility and value of using a Large Language Model (LLM)-based multi-agent system (MAS) for safer therapy recommendations. We designed a single agent and a MAS framework simulating MDT decision-making by enabling discussion among LLM agents to resolve medical conflicts. The systems were evaluated on therapy planning tasks for multimorbidity patients using benchmark cases. We compared MAS performance with single-agent approaches and real-world benchmarks. An important contribution of our study is the definition of evaluation metrics that go beyond the technical precision and recall and allow the inspection of clinical goals met and medication burden of the proposed advices to a gold standard benchmark. Our results show that with current LLMs, a single agent GP performs as well as MDTs. The best-scoring models provide correct recommendations that address all clinical goals, yet the advices are incomplete. Some models also present unnecessary medications, resulting in unnecessary conflicts between medication and conditions or drug-drug interactions.

Zhengyao Ding, Ziyu Li, Yujian Hu et al.

Cardiovascular diseases (CVDs) are the leading cause of global mortality, necessitating accessible and accurate diagnostic tools. While cardiac magnetic resonance imaging (CMR) provides gold-standard insights into cardiac structure and function, its clinical utility is limited by high cost and complexity. In contrast, electrocardiography (ECG) is inexpensive and widely available but lacks the granularity of CMR. We propose CardioNets, a deep learning framework that translates 12-lead ECG signals into CMR-level functional parameters and synthetic images, enabling scalable cardiac assessment. CardioNets integrates cross-modal contrastive learning and generative pretraining, aligning ECG with CMR-derived cardiac phenotypes and synthesizing high-resolution CMR images via a masked autoregressive model. Trained on 159,819 samples from five cohorts, including the UK Biobank (n=42,483) and MIMIC-IV-ECG (n=164,550), and externally validated on independent clinical datasets (n=3,767), CardioNets achieved strong performance across disease screening and phenotype estimation tasks. In the UK Biobank, it improved cardiac phenotype regression R2 by 24.8% and cardiomyopathy AUC by up to 39.3% over baseline models. In MIMIC, it increased AUC for pulmonary hypertension detection by 5.6%. Generated CMR images showed 36.6% higher SSIM and 8.7% higher PSNR than prior approaches. In a reader study, ECG-only CardioNets achieved 13.9% higher accuracy than human physicians using both ECG and real CMR. These results suggest that CardioNets offers a promising, low-cost alternative to CMR for large-scale CVD screening, particularly in resource-limited settings. Future efforts will focus on clinical deployment and regulatory validation of ECG-based synthetic imaging.

Kaize Ding, Albert Jiongqian Liang, Bryan Perrozi et al.

Learning expressive representations for high-dimensional yet sparse features has been a longstanding problem in information retrieval. Though recent deep learning methods can partially solve the problem, they often fail to handle the numerous sparse features, particularly those tail feature values with infrequent occurrences in the training data. Worse still, existing methods cannot explicitly leverage the correlations among different instances to help further improve the representation learning on sparse features since such relational prior knowledge is not provided. To address these challenges, in this paper, we tackle the problem of representation learning on feature-sparse data from a graph learning perspective. Specifically, we propose to model the sparse features of different instances using hypergraphs where each node represents a data instance and each hyperedge denotes a distinct feature value. By passing messages on the constructed hypergraphs based on our Hypergraph Transformer (HyperFormer), the learned feature representations capture not only the correlations among different instances but also the correlations among features. Our experiments demonstrate that the proposed approach can effectively improve feature representation learning on sparse features.