Yifan Wang

Ruochi Zhang, Haoran Wu, Chang Liu et al.

Recent advances in protein language models have catalyzed significant progress in peptide sequence representation. Despite extensive exploration in this field, pre-trained models tailored for peptide-specific needs remain largely unaddressed due to the difficulty in capturing the complex and sometimes unstable structures of peptides. This study introduces a novel multi-view contrastive learning framework PepHarmony for the sequence-based peptide encoding task. PepHarmony innovatively combines both sequence- and structure-level information into a sequence-level encoding module through contrastive learning. We carefully select datasets from the Protein Data Bank (PDB) and AlphaFold database to encompass a broad spectrum of peptide sequences and structures. The experimental data highlights PepHarmony's exceptional capability in capturing the intricate relationship between peptide sequences and structures compared with the baseline and fine-tuned models. The robustness of our model is confirmed through extensive ablation studies, which emphasize the crucial roles of contrastive loss and strategic data sorting in enhancing predictive performance. The proposed PepHarmony framework serves as a notable contribution to peptide representations, and offers valuable insights for future applications in peptide drug discovery and peptide engineering. We have made all the source code utilized in this study publicly accessible via GitHub at https://github.com/zhangruochi/PepHarmony or http://www.healthinformaticslab.org/supp/.

Xuecheng Wu, Jiaxing Liu, Danlei Huang et al.

Visual-Interleaved Chain-of-Thought (VI-CoT) enables MLLMs to continually update their understanding and decisions based on step-wise intermediate visual states (IVS), much like a human would, which demonstrates impressive success in various tasks, thereby leading to emerged advancements in related benchmarks. Despite promising progress, current benchmarks provide models with relatively fixed IVS, rather than free-style IVS, whch might forcibly distort the original thinking trajectories, failing to evaluate their intrinsic reasoning capabilities. More importantly, existing benchmarks neglect to systematically explore the impact factors that IVS would impart to untamed reasoning performance. To tackle above gaps, we introduce a specialized benchmark termed ViC-Bench, consisting of four representive tasks: maze navigation, jigsaw puzzle, embodied long-horizon planning, and complex counting, where each task has dedicated free-style IVS generation pipeline supporting function calls. To systematically examine VI-CoT capability, we propose a thorough evaluation suite incorporating a progressive three-stage strategy with targeted new metrics. Besides, we establish Incremental Prompting Information Injection (IPII) strategy to ablatively explore the prompting factors for VI-CoT. We extensively conduct evaluations for 18 advanced MLLMs, revealing key insights into their VI-CoT capability. Our proposed benchmark is publicly open at Huggingface.

Yifan Wang, Hongfeng Ai, Ruiqi Li et al.

In medical time series disease diagnosis, two key challenges are identified.First, the high annotation cost of medical data leads to overfitting in models trained on label-limited, single-center datasets. To address this, we propose incorporating external data from related tasks and leveraging AE-GAN to extract prior knowledge,providing valuable references for downstream tasks. Second, many existing studies employ contrastive learning to derive more generalized medical sequence representations for diagnostic tasks, usually relying on manually designed diverse positive and negative sample pairs.However, these approaches are complex, lack generalizability, and fail to adaptively capture disease-specific features across different conditions.To overcome this, we introduce LMCF (Learnable Multi-views Contrastive Framework), a framework that integrates a multi-head attention mechanism and adaptively learns representations from different views through inter-view and intra-view contrastive learning strategies.Additionally, the pre-trained AE-GAN is used to reconstruct discrepancies in the target data as disease probabilities, which are then integrated into the contrastive learning process.Experiments on three target datasets demonstrate that our method consistently outperforms seven other baselines, highlighting its significant impact on healthcare applications such as the diagnosis of myocardial infarction, Alzheimer's disease, and Parkinson's disease.

Yang Zheng, Hao Tan, Kai Zhang et al.

The rise of 3D Gaussian Splatting has revolutionized photorealistic 3D asset creation, yet a critical gap remains for their interactive refinement and editing. Existing approaches based on diffusion or optimization are ill-suited for this task, as they are often prohibitively slow, destructive to the original asset's identity, or lack the precision for fine-grained control. To address this, we introduce \ourmethod, a state-aware feedforward model that enables continuous editing of 3D Gaussian assets from user-provided 2D view(s). Our method directly predicts updates to the attributes of a compact, feature-rich Gaussian representation and leverages Test-Time Training to create a state-aware, iterative workflow. The versatility of our approach allows a single architecture to perform diverse tasks, including high-fidelity local detail refinement, local paint-over, and consistent global recoloring, all at interactive speeds, paving the way for fluid and intuitive 3D content authoring.

Ruikun Luo, Yifan Weng, Yifan Wang et al.

Haptic shared control is used to manage the control authority allocation between a human and an autonomous agent in semi-autonomous driving. Existing haptic shared control schemes, however, do not take full consideration of the human agent. To fill this research gap, this study presents a haptic shared control scheme that adapts to a human operator's workload, eyes on road and input torque in real-time. We conducted human-in-the-loop experiments with 24 participants. In the experiment, a human operator and an autonomy module for navigation shared the control of a simulated notional High Mobility Multipurpose Wheeled Vehicle (HMMWV) at a fixed speed. At the same time, the human operator performed a target detection task for surveillance. The autonomy could be either adaptive or non-adaptive to the above-mentioned human factors. Results indicate that the adaptive haptic control scheme resulted in significantly lower workload, higher trust in autonomy, better driving task performance and smaller control effort.