Qian Zhang

Haomiao Ni, Yuan Xue, Liya Ma et al.

General movement assessment (GMA) of infant movement videos (IMVs) is an effective method for early detection of cerebral palsy (CP) in infants. We demonstrate in this paper that end-to-end trainable neural networks for image sequence recognition can be applied to achieve good results in GMA, and more importantly, augmenting raw video with infant body parsing and pose estimation information can significantly improve performance. To solve the problem of efficiently utilizing partially labeled IMVs for body parsing, we propose a semi-supervised model, termed SiamParseNet (SPN), which consists of two branches, one for intra-frame body parts segmentation and another for inter-frame label propagation. During training, the two branches are jointly trained by alternating between using input pairs of only labeled frames and input of both labeled and unlabeled frames. We also investigate training data augmentation by proposing a factorized video generative adversarial network (FVGAN) to synthesize novel labeled frames for training. When testing, we employ a multi-source inference mechanism, where the final result for a test frame is either obtained via the segmentation branch or via propagation from a nearby key frame. We conduct extensive experiments for body parsing using SPN on two infant movement video datasets, where SPN coupled with FVGAN achieves state-of-the-art performance. We further demonstrate that SPN can be easily adapted to the infant pose estimation task with superior performance. Last but not least, we explore the clinical application of our method for GMA. We collected a new clinical IMV dataset with GMA annotations, and our experiments show that SPN models for body parsing and pose estimation trained on the first two datasets generalize well to the new clinical dataset and their results can significantly boost the CRNN-based GMA prediction performance.

Haomiao Ni, Yuan Xue, Qian Zhang et al.

General movement assessment (GMA) of infant movement videos (IMVs) is an effective method for the early detection of cerebral palsy (CP) in infants. Automated body parsing is a crucial step towards computer-aided GMA, in which infant body parts are segmented and tracked over time for movement analysis. However, acquiring fully annotated data for video-based body parsing is particularly expensive due to the large number of frames in IMVs. In this paper, we propose a semi-supervised body parsing model, termed SiamParseNet (SPN), to jointly learn single frame body parsing and label propagation between frames in a semi-supervised fashion. The Siamese-structured SPN consists of a shared feature encoder, followed by two separate branches: one for intra-frame body parts segmentation, and one for inter-frame label propagation. The two branches are trained jointly, taking pairs of frames from the same videos as their input. An adaptive training process is proposed that alternates training modes between using input pairs of only labeled frames and using inputs of both labeled and unlabeled frames. During testing, we employ a multi-source inference mechanism, where the final result for a test frame is either obtained via the segmentation branch or via propagation from a nearby key frame. We conduct extensive experiments on a partially-labeled IMV dataset where SPN outperforms all prior arts, demonstrating the effectiveness of our proposed method.

Qian Zhang, Li Wang, Xiaopeng Zong et al.

Skull stripping for brain MR images is a basic segmentation task. Although many methods have been proposed, most of them focused mainly on the adult MR images. Skull stripping for infant MR images is more challenging due to the small size and dynamic intensity changes of brain tissues during the early ages. In this paper, we propose a novel CNN based framework to robustly extract brain region from infant MR image without any human assistance. Specifically, we propose a simplified but more robust flattened residual network architecture (FRnet). We also introduce a new boundary loss function to highlight ambiguous and low contrast regions between brain and non-brain regions. To make the whole framework more robust to MR images with different imaging quality, we further introduce an artifact simulator for data augmentation. We have trained and tested our proposed framework on a large dataset (N=343), covering newborns to 48-month-olds, and obtained performance better than the state-of-the-art methods in all age groups.