Jian Li

Fangxin Liu, Zongwu Wang, JinHong Xia et al.

The rapid advancement of large language models (LLMs) has exacerbated the memory bottleneck due to the widening gap between model parameter scaling and hardware capabilities. While post-training quantization techniques effectively reduce memory overhead, existing methods predominantly rely on static quantization strategies, which struggle to adapt to dynamic workloads. To address this, we propose FlexQuant, a dynamic precision-switching framework that optimizes the trade-off between inference speed and accuracy. Leveraging model perplexity entropy and Kullback-Leibler divergence, FlexQuant enables fine-grained, layer-wise mixed-precision quantization and dynamically adjusts bit-widths during each token generation. FlexQuant provides a comprehensive analysis of quantization strategies, introduces a precision requirement model for optimal switching, and implements efficient fine-grained precision management. Evaluations demonstrate that FlexQuant achieves a 1.3x end-to-end speedup across diverse language tasks with negligible accuracy loss introduced. This framework offers a flexible and adaptive solution for efficient LLM deployment. Code is released at https://github.com/ZongwuWang/FlexQuant.git.

Jingfeng Guo, Jian Liu, Jinnan Chen et al.

We introduce Auto-Connect, a novel approach for automatic rigging that explicitly preserves skeletal connectivity through a connectivity-preserving tokenization scheme. Unlike previous methods that predict bone positions represented as two joints or first predict points before determining connectivity, our method employs special tokens to define endpoints for each joint's children and for each hierarchical layer, effectively automating connectivity relationships. This approach significantly enhances topological accuracy by integrating connectivity information directly into the prediction framework. To further guarantee high-quality topology, we implement a topology-aware reward function that quantifies topological correctness, which is then utilized in a post-training phase through reward-guided Direct Preference Optimization. Additionally, we incorporate implicit geodesic features for latent top-k bone selection, which substantially improves skinning quality. By leveraging geodesic distance information within the model's latent space, our approach intelligently determines the most influential bones for each vertex, effectively mitigating common skinning artifacts. This combination of connectivity-preserving tokenization, reward-guided fine-tuning, and geodesic-aware bone selection enables our model to consistently generate more anatomically plausible skeletal structures with superior deformation properties.

Liang Zeng, Lanqing Li, Jian Li

How to effectively represent molecules is a long-standing challenge for molecular property prediction and drug discovery. This paper studies this problem and proposes to incorporate chemical domain knowledge, specifically related to chemical reactions, for learning effective molecular representations. However, the inherent cross-modality property between chemical reactions and molecules presents a significant challenge to address. To this end, we introduce a novel method, namely MolKD, which Distills cross-modal Knowledge in chemical reactions to assist Molecular property prediction. Specifically, the reaction-to-molecule distillation model within MolKD transfers cross-modal knowledge from a pre-trained teacher network learning with one modality (i.e., reactions) into a student network learning with another modality (i.e., molecules). Moreover, MolKD learns effective molecular representations by incorporating reaction yields to measure transformation efficiency of the reactant-product pair when pre-training on reactions. Extensive experiments demonstrate that MolKD significantly outperforms various competitive baseline models, e.g., 2.1% absolute AUC-ROC gain on Tox21. Further investigations demonstrate that pre-trained molecular representations in MolKD can distinguish chemically reasonable molecular similarities, which enables molecular property prediction with high robustness and interpretability.