Zhe Wang

Hai Yang, Yuhang Sheng, Yi Jiang et al.

Motivation: Cancer is heterogeneous, affecting the precise approach to personalized treatment. Accurate subtyping can lead to better survival rates for cancer patients. High-throughput technologies provide multiple omics data for cancer subtyping. However, precise cancer subtyping remains challenging due to the large amount and high dimensionality of omics data. Results: This study proposed Subtype-Former, a deep learning method based on MLP and Transformer Block, to extract the low-dimensional representation of the multi-omics data. K-means and Consensus Clustering are also used to achieve accurate subtyping results. We compared Subtype-Former with the other state-of-the-art subtyping methods across the TCGA 10 cancer types. We found that Subtype-Former can perform better on the benchmark datasets of more than 5000 tumors based on the survival analysis. In addition, Subtype-Former also achieved outstanding results in pan-cancer subtyping, which can help analyze the commonalities and differences across various cancer types at the molecular level. Finally, we applied Subtype-Former to the TCGA 10 types of cancers. We identified 50 essential biomarkers, which can be used to study targeted cancer drugs and promote the development of cancer treatments in the era of precision medicine.

Ting Xiao, Lei Shi, Peng Liu et al.

Automatic Radiology Report Generation (RRG) is an important topic for alleviating the substantial workload of radiologists. Existing RRG approaches rely on supervised regression based on different architectures or additional knowledge injection,while the generated report may not align optimally with radiologists' preferences. Especially, since the preferences of radiologists are inherently heterogeneous and multidimensional, e.g., some may prioritize report fluency, while others emphasize clinical accuracy. To address this problem,we propose a new RRG method via Multi-objective Preference Optimization (MPO) to align the pre-trained RRG model with multiple human preferences, which can be formulated by multi-dimensional reward functions and optimized by multi-objective reinforcement learning (RL). Specifically, we use a preference vector to represent the weight of preferences and use it as a condition for the RRG model. Then, a linearly weighed reward is obtained via a dot product between the preference vector and multi-dimensional reward. Next,the RRG model is optimized to align with the preference vector by optimizing such a reward via RL. In the training stage,we randomly sample diverse preference vectors from the preference space and align the model by optimizing the weighted multi-objective rewards, which leads to an optimal policy on the entire preference space. When inference,our model can generate reports aligned with specific preferences without further fine-tuning. Extensive experiments on two public datasets show the proposed method can generate reports that cater to different preferences in a single model and achieve state-of-the-art performance.

Chengyao Qian, Ting Liu, Hao Jiang et al.

This report summarises our method and validation results for the ISIC Challenge 2018 - Skin Lesion Analysis Towards Melanoma Detection - Task 1: Lesion Segmentation. We present a two-stage method for lesion segmentation with optimised training method and ensemble post-process. Our method achieves state-of-the-art performance on lesion segmentation and we win the first place in ISIC 2018 task1.