Bo Wang

Adibvafa Fallahpour, Andrew Magnuson, Purav Gupta et al. · deepmind, utoronto

Unlocking deep and interpretable biological reasoning from complex genomic data remains a major AI challenge limiting scientific progress. While current DNA foundation models excel at representing sequences, they struggle with multi-step reasoning and lack transparent, biologically meaningful explanations. BioReason addresses this by tightly integrating a DNA foundation model with a large language model (LLM), enabling the LLM to directly interpret and reason over genomic information. Through supervised fine-tuning and reinforcement learning, BioReason learns to produce logical, biologically coherent deductions. It achieves major performance gains, boosting KEGG-based disease pathway prediction accuracy from 86% to 98% and improving variant effect prediction by an average of 15% over strong baselines. BioReason can reason over unseen biological entities and explain its decisions step by step, offering a transformative framework for interpretable, mechanistic AI in biology. All data, code, and checkpoints are available at https://github.com/bowang-lab/BioReason

Yachao Zhao, Bo Wang, Yan Wang et al.

Large Language Models (LLMs) have been shown to exhibit various biases and stereotypes in their generated content. While extensive research has investigated biases in LLMs, prior work has predominantly focused on explicit bias, with minimal attention to implicit bias and the relation between these two forms of bias. This paper presents a systematic framework grounded in social psychology theories to investigate and compare explicit and implicit biases in LLMs. We propose a novel self-reflection-based evaluation framework that operates in two phases: first measuring implicit bias through simulated psychological assessment methods, then evaluating explicit bias by prompting LLMs to analyze their own generated content. Through extensive experiments on advanced LLMs across multiple social dimensions, we demonstrate that LLMs exhibit a substantial inconsistency between explicit and implicit biases: while explicit bias manifests as mild stereotypes, implicit bias exhibits strong stereotypes. We further investigate the underlying factors contributing to this explicit-implicit bias inconsistency, examining the effects of training data scale, model size, and alignment techniques. Experimental results indicate that while explicit bias declines with increased training data and model size, implicit bias exhibits a contrasting upward trend. Moreover, contemporary alignment methods effectively suppress explicit bias but show limited efficacy in mitigating implicit bias.