Chao Chen

Moinak Bhattacharya, Judy Huang, Amna F. Sher et al.

Accurately predicting immunotherapy response in Non-Small Cell Lung Cancer (NSCLC) remains a critical unmet need. Existing radiomics and deep learning-based predictive models rely primarily on pre-treatment imaging to predict categorical response outcomes, limiting their ability to capture the complex morphological and textural transformations induced by immunotherapy. This study introduces ImmunoDiff, an anatomy-aware diffusion model designed to synthesize post-treatment CT scans from baseline imaging while incorporating clinically relevant constraints. The proposed framework integrates anatomical priors, specifically lobar and vascular structures, to enhance fidelity in CT synthesis. Additionally, we introduce a novel cbi-Adapter, a conditioning module that ensures pairwise-consistent multimodal integration of imaging and clinical data embeddings, to refine the generative process. Additionally, a clinical variable conditioning mechanism is introduced, leveraging demographic data, blood-based biomarkers, and PD-L1 expression to refine the generative process. Evaluations on an in-house NSCLC cohort treated with immune checkpoint inhibitors demonstrate a 21.24% improvement in balanced accuracy for response prediction and a 0.03 increase in c-index for survival prediction. Code will be released soon.

Chao Chen, Chenghua Guo, Rui Xu et al.

Graphical models have demonstrated their exceptional capabilities across numerous applications, such as social networks, citation networks, and online recommendation systems. However, their performance, confidence, and trustworthiness are often limited by the inherent randomness in data and the challenges of accurately modeling real-world complexities. There has been increased interest in developing uncertainty quantification (UQ) techniques tailored to graphical models. In this survey, we comprehensively examine existing works on UQ for graphical models, focusing on key aspects such as the sources, representation, handling, and evaluation of uncertainty. This survey distinguishes itself from most existing UQ surveys by specifically concentrating on UQ in graphical models, including probabilistic graphical models (PGMs) and graph neural networks (GNNs). After reviewing sources of uncertainty, we organize the work using two high-level dimensions: uncertainty representation and uncertainty handling. By offering a comprehensive overview of the current landscape, including both established methodologies and emerging trends, we aim to bridge gaps in understanding key challenges and opportunities in UQ for graphical models, hoping to inspire researchers working on graphical models or uncertainty quantification to make further advancements at the cross of the two fields.