Hong Liu

Hong Liu, Haosen Yang, Federica Eduati et al.

Leveraging multimodal data, particularly the integration of whole-slide histology images (WSIs) and transcriptomic profiles, holds great promise for improving cancer survival prediction. However, excessive redundancy in multimodal data can degrade model performance. In this paper, we propose Adaptive Prototype Learning (APL), a novel and effective approach for multimodal cancer survival analysis. APL adaptively learns representative prototypes in a data-driven manner, reducing redundancy while preserving critical information. Our method employs two sets of learnable query vectors that serve as a bridge between high-dimensional representations and survival prediction, capturing task-relevant features. Additionally, we introduce a multimodal mixed self-attention mechanism to enable cross-modal interactions, further enhancing information fusion. Extensive experiments on five benchmark cancer datasets demonstrate the superiority of our approach over existing methods. The code is available at https://github.com/HongLiuuuuu/APL.

Zheng Wang, Hong Liu, Zheng Wang et al.

Survival analysis based on Whole Slide Images (WSIs) is crucial for evaluating cancer prognosis, as they offer detailed microscopic information essential for predicting patient outcomes. However, traditional WSI-based survival analysis usually faces noisy features and limited data accessibility, hindering their ability to capture critical prognostic features effectively. Although pathology reports provide rich patient-specific information that could assist analysis, their potential to enhance WSI-based survival analysis remains largely unexplored. To this end, this paper proposes a novel Report-auxiliary self-distillation (Rasa) framework for WSI-based survival analysis. First, advanced large language models (LLMs) are utilized to extract fine-grained, WSI-relevant textual descriptions from original noisy pathology reports via a carefully designed task prompt. Next, a self-distillation-based pipeline is designed to filter out irrelevant or redundant WSI features for the student model under the guidance of the teacher model's textual knowledge. Finally, a risk-aware mix-up strategy is incorporated during the training of the student model to enhance both the quantity and diversity of the training data. Extensive experiments carried out on our collected data (CRC) and public data (TCGA-BRCA) demonstrate the superior effectiveness of Rasa against state-of-the-art methods. Our code is available at https://github.com/zhengwang9/Rasa.

Liwei Lin, Xiangdong Wang, Hong Liu et al.

In this paper, a special decision surface for the weakly-supervised sound event detection (SED) and a disentangled feature (DF) for the multi-label problem in polyphonic SED are proposed. We approach SED as a multiple instance learning (MIL) problem and utilize a neural network framework with a pooling module to solve it. General MIL approaches include two kinds: the instance-level approaches and embedding-level approaches. We present a method of generating instance-level probabilities for the embedding level approaches which tend to perform better than the instance-level approaches in terms of bag-level classification but can not provide instance-level probabilities in current approaches. Moreover, we further propose a specialized decision surface (SDS) for the embedding-level attention pooling. We analyze and explained why an embedding-level attention module with SDS is better than other typical pooling modules from the perspective of the high-level feature space. As for the problem of the unbalanced dataset and the co-occurrence of multiple categories in the polyphonic event detection task, we propose a DF to reduce interference among categories, which optimizes the high-level feature space by disentangling it based on class-wise identifiable information and obtaining multiple different subspaces. Experiments on the dataset of DCASE 2018 Task 4 show that the proposed SDS and DF significantly improve the detection performance of the embedding-level MIL approach with an attention pooling module and outperform the first place system in the challenge by 6.6 percentage points.