Lin Li

Jianing Qiu, Lin Li, Jiankai Sun et al.

Large AI models, or foundation models, are models recently emerging with massive scales both parameter-wise and data-wise, the magnitudes of which can reach beyond billions. Once pretrained, large AI models demonstrate impressive performance in various downstream tasks. A prime example is ChatGPT, whose capability has compelled people's imagination about the far-reaching influence that large AI models can have and their potential to transform different domains of our lives. In health informatics, the advent of large AI models has brought new paradigms for the design of methodologies. The scale of multi-modal data in the biomedical and health domain has been ever-expanding especially since the community embraced the era of deep learning, which provides the ground to develop, validate, and advance large AI models for breakthroughs in health-related areas. This article presents a comprehensive review of large AI models, from background to their applications. We identify seven key sectors in which large AI models are applicable and might have substantial influence, including 1) bioinformatics; 2) medical diagnosis; 3) medical imaging; 4) medical informatics; 5) medical education; 6) public health; and 7) medical robotics. We examine their challenges, followed by a critical discussion about potential future directions and pitfalls of large AI models in transforming the field of health informatics.

Fenia Christopoulou, Gerasimos Lampouras, Milan Gritta et al.

We present PanGu-Coder, a pretrained decoder-only language model adopting the PanGu-Alpha architecture for text-to-code generation, i.e. the synthesis of programming language solutions given a natural language problem description. We train PanGu-Coder using a two-stage strategy: the first stage employs Causal Language Modelling (CLM) to pre-train on raw programming language data, while the second stage uses a combination of Causal Language Modelling and Masked Language Modelling (MLM) training objectives that focus on the downstream task of text-to-code generation and train on loosely curated pairs of natural language program definitions and code functions. Finally, we discuss PanGu-Coder-FT, which is fine-tuned on a combination of competitive programming problems and code with continuous integration tests. We evaluate PanGu-Coder with a focus on whether it generates functionally correct programs and demonstrate that it achieves equivalent or better performance than similarly sized models, such as CodeX, while attending a smaller context window and training on less data.

Chong Lyu, Lin Li, Shiqing Wu et al.

The increasing utilization of large language models raises significant concerns about the propagation of social biases, which may result in harmful and unfair outcomes. However, existing debiasing methods treat the biased and unbiased samples independently, thus ignoring their mutual relationship. This oversight enables a hidden negative-positive coupling, where improvements for one group inadvertently compromise the other, allowing residual social bias to persist. In this paper, we introduce TriCon-Fair, a contrastive learning framework that employs a decoupled loss that combines triplet and language modeling terms to eliminate positive-negative coupling. Our TriCon-Fair assigns each anchor an explicitly biased negative and an unbiased positive, decoupling the push-pull dynamics and avoiding positive-negative coupling, and jointly optimizes a language modeling (LM) objective to preserve general capability. Experimental results demonstrate that TriCon-Fair reduces discriminatory output beyond existing debiasing baselines while maintaining strong downstream performance. This suggests that our proposed TriCon-Fair offers a practical and ethical solution for sensitive NLP applications.

Jisoo Lee, Michael R. Harowicz, Yuwen Chen et al.

This study evaluates publicly available deep-learning based lung segmentation models in transplant-eligible patients to determine their performance across disease severity levels, pathology categories, and lung sides, and to identify limitations impacting their use in preoperative planning in lung transplantation. This retrospective study included 32 patients who underwent chest CT scans at Duke University Health System between 2017 and 2019 (total of 3,645 2D axial slices). Patients with standard axial CT scans were selected based on the presence of two or more lung pathologies of varying severity. Lung segmentation was performed using three previously developed deep learning models: Unet-R231, TotalSegmentator, MedSAM. Performance was assessed using quantitative metrics (volumetric similarity, Dice similarity coefficient, Hausdorff distance) and a qualitative measure (four-point clinical acceptability scale). Unet-R231 consistently outperformed TotalSegmentator and MedSAM in general, for different severity levels, and pathology categories (p<0.05). All models showed significant performance declines from mild to moderate-to-severe cases, particularly in volumetric similarity (p<0.05), without significant differences among lung sides or pathology types. Unet-R231 provided the most accurate automated lung segmentation among evaluated models with TotalSegmentator being a close second, though their performance declined significantly in moderate-to-severe cases, emphasizing the need for specialized model fine-tuning in severe pathology contexts.

Benign John Ihugba, Afsana Nasrin, Ling Wu et al.

Mass-shooting events pose a significant challenge to public safety, generating large volumes of unstructured textual data that hinder effective investigations and the formulation of public policy. Despite the urgency, few prior studies have effectively automated the extraction of key information from these events to support legal and investigative efforts. This paper presented the first dataset designed for knowledge acquisition on mass-shooting events through the application of named entity recognition (NER) techniques. It focuses on identifying key entities such as offenders, victims, locations, and criminal instruments, that are vital for legal and investigative purposes. The NER process is powered by Large Language Models (LLMs) using few-shot prompting, facilitating the efficient extraction and organization of critical information from diverse sources, including news articles, police reports, and social media. Experimental results on real-world mass-shooting corpora demonstrate that GPT-4o is the most effective model for mass-shooting NER, achieving the highest Micro Precision, Micro Recall, and Micro F1-scores. Meanwhile, o1-mini delivers competitive performance, making it a resource-efficient alternative for less complex NER tasks. It is also observed that increasing the shot count enhances the performance of all models, but the gains are more substantial for GPT-4o and o1-mini, highlighting their superior adaptability to few-shot learning scenarios.

Lin Li, Chao Chen, Lei Pan et al.

Biometric authentication prospered because of its convenient use and security. Early generations of biometric mechanisms suffer from spoofing attacks. Recently, unobservable physiological signals (e.g., Electroencephalogram, Photoplethysmogram, Electrocardiogram) as biometrics offer a potential remedy to this problem. In particular, Photoplethysmogram (PPG) measures the change in blood flow of the human body by an optical method. Clinically, researchers commonly use PPG signals to obtain patients' blood oxygen saturation, heart rate, and other information to assist in diagnosing heart-related diseases. Since PPG signals contain a wealth of individual cardiac information, researchers have begun to explore their potential in cyber security applications. The unique advantages (simple acquisition, difficult to steal, and live detection) of the PPG signal allow it to improve the security and usability of the authentication in various aspects. However, the research on PPG-based authentication is still in its infancy. The lack of systematization hinders new research in this field. We conduct a comprehensive study of PPG-based authentication and discuss these applications' limitations before pointing out future research directions.

Yicong Li, Hongxu Chen, Yile Li et al.

Recent advances in path-based explainable recommendation systems have attracted increasing attention thanks to the rich information provided by knowledge graphs. Most existing explainable recommendations only utilize static knowledge graphs and ignore the dynamic user-item evolutions, leading to less convincing and inaccurate explanations. Although there are some works that realize that modelling user's temporal sequential behaviour could boost the performance and explainability of the recommender systems, most of them either only focus on modelling user's sequential interactions within a path or independently and separately of the recommendation mechanism. In this paper, we propose a novel Temporal Meta-path Guided Explainable Recommendation leveraging Reinforcement Learning (TMER-RL), which utilizes reinforcement item-item path modelling between consecutive items with attention mechanisms to sequentially model dynamic user-item evolutions on dynamic knowledge graph for explainable recommendation. Compared with existing works that use heavy recurrent neural networks to model temporal information, we propose simple but effective neural networks to capture users' historical item features and path-based context to characterize the next purchased item. Extensive evaluations of TMER on two real-world datasets show state-of-the-art performance compared against recent strong baselines.

Haoran Yang, Hongxu Chen, Lin Li et al.

User purchasing prediction with multi-behavior information remains a challenging problem for current recommendation systems. Various methods have been proposed to address it via leveraging the advantages of graph neural networks (GNNs) or multi-task learning. However, most existing works do not take the complex dependencies among different behaviors of users into consideration. They utilize simple and fixed schemes, like neighborhood information aggregation or mathematical calculation of vectors, to fuse the embeddings of different user behaviors to obtain a unified embedding to represent a user's behavioral patterns which will be used in downstream recommendation tasks. To tackle the challenge, in this paper, we first propose the concept of hyper meta-path to construct hyper meta-paths or hyper meta-graphs to explicitly illustrate the dependencies among different behaviors of a user. How to obtain a unified embedding for a user from hyper meta-paths and avoid the previously mentioned limitations simultaneously is critical. Thanks to the recent success of graph contrastive learning, we leverage it to learn embeddings of user behavior patterns adaptively instead of assigning a fixed scheme to understand the dependencies among different behaviors. A new graph contrastive learning based framework is proposed by coupling with hyper meta-paths, namely HMG-CR, which consistently and significantly outperforms all baselines in extensive comparison experiments.

Peipei Wang, Lin Li, Yi Yu et al.

Frequent group activities of human beings have become an indispensable part in their daily life. Group recommendation can recommend satisfactory activities to group members in the recommender systems, and the key issue is how to aggregate preferences in different group members. Most existing group recommendation employed the predefined static aggregation strategies to aggregate the preferences of different group members, but these static strategies cannot simulate the dynamic group decision-making. Meanwhile, most of these methods depend on intuitions or assumptions to analyze the influence of group members and lack of convincing theoretical support. We argue that the influence of group members plays a particularly important role in group decision-making and it can better assist group profile modeling and perform more accurate group recommendation. To tackle the issue of preference aggregation for group recommendation, we propose a novel attentive aggregation representation learning method based on sociological theory for group recommendation, namely SIAGR (short for "Social Influence-based Attentive Group Recommendation"), which takes attention mechanisms and the popular method (BERT) as the aggregation representation for group profile modeling. Specifically, we analyze the influence of group members based on social identity theory and two-step flow theory and exploit an attentive mavens mining method. In addition, we develop a BERT-based representation method to learn the interaction of group members. Lastly, we complete the group recommendation under the neural collaborative filtering framework and verify the effectiveness of the proposed method by experimenting.