Xiaoyu Zhang

Junjie Zheng, Chunbo Hao, Guobin Ma et al.

Singing Voice Synthesis (SVS) remains constrained in practical deployment due to its strong dependence on accurate phoneme-level alignment and manually annotated melody contours, requirements that are resource-intensive and hinder scalability. To overcome these limitations, we propose a melody-driven SVS framework capable of synthesizing arbitrary lyrics following any reference melody, without relying on phoneme-level alignment. Our method builds on a Diffusion Transformer (DiT) architecture, enhanced with a dedicated melody extraction module that derives melody representations directly from reference audio. To ensure robust melody encoding, we employ a teacher model to guide the optimization of the melody extractor, alongside an implicit alignment mechanism that enforces similarity distribution constraints for improved melodic stability and coherence. Additionally, we refine duration modeling using weakly annotated song data and introduce a Flow-GRPO reinforcement learning strategy with a multi-objective reward function to jointly enhance pronunciation clarity and melodic fidelity. Experiments show that our model achieves superior performance over existing approaches in both objective measures and subjective listening tests, especially in zero-shot and lyric adaptation settings, while maintaining high audio quality without manual annotation. This work offers a practical and scalable solution for advancing data-efficient singing voice synthesis. To support reproducibility, we release our inference code and model checkpoints.

Jingqing Zhang, Xiaoyu Zhang, Kai Sun et al.

The extraction of phenotype information which is naturally contained in electronic health records (EHRs) has been found to be useful in various clinical informatics applications such as disease diagnosis. However, due to imprecise descriptions, lack of gold standards and the demand for efficiency, annotating phenotypic abnormalities on millions of EHR narratives is still challenging. In this work, we propose a novel unsupervised deep learning framework to annotate the phenotypic abnormalities from EHRs via semantic latent representations. The proposed framework takes the advantage of Human Phenotype Ontology (HPO), which is a knowledge base of phenotypic abnormalities, to standardize the annotation results. Experiments have been conducted on 52,722 EHRs from MIMIC-III dataset. Quantitative and qualitative analysis have shown the proposed framework achieves state-of-the-art annotation performance and computational efficiency compared with other methods.

Xiaoyu Zhang, Jingqing Zhang, Kai Sun et al.

Different aspects of a clinical sample can be revealed by multiple types of omics data. Integrated analysis of multi-omics data provides a comprehensive view of patients, which has the potential to facilitate more accurate clinical decision making. However, omics data are normally high dimensional with large number of molecular features and relatively small number of available samples with clinical labels. The "dimensionality curse" makes it challenging to train a machine learning model using high dimensional omics data like DNA methylation and gene expression profiles. Here we propose an end-to-end deep learning model called OmiVAE to extract low dimensional features and classify samples from multi-omics data. OmiVAE combines the basic structure of variational autoencoders with a classification network to achieve task-oriented feature extraction and multi-class classification. The training procedure of OmiVAE is comprised of an unsupervised phase without the classifier and a supervised phase with the classifier. During the unsupervised phase, a hierarchical cluster structure of samples can be automatically formed without the need for labels. And in the supervised phase, OmiVAE achieved an average classification accuracy of 97.49% after 10-fold cross-validation among 33 tumour types and normal samples, which shows better performance than other existing methods. The OmiVAE model learned from multi-omics data outperformed that using only one type of omics data, which indicates that the complementary information from different omics datatypes provides useful insights for biomedical tasks like cancer classification.