Siqi Wang

Zitong Chen, Chau Pham, Siqi Wang et al.

Most neural networks assume that input images have a fixed number of channels (three for RGB images). However, there are many settings where the number of channels may vary, such as microscopy images where the number of channels changes depending on instruments and experimental goals. Yet, there has not been a systemic attempt to create and evaluate neural networks that are invariant to the number and type of channels. As a result, trained models remain specific to individual studies and are hardly reusable for other microscopy settings. In this paper, we present a benchmark for investigating channel-adaptive models in microscopy imaging, which consists of 1) a dataset of varied-channel single-cell images, and 2) a biologically relevant evaluation framework. In addition, we adapted several existing techniques to create channel-adaptive models and compared their performance on this benchmark to fixed-channel, baseline models. We find that channel-adaptive models can generalize better to out-of-domain tasks and can be computationally efficient. We contribute a curated dataset (https://doi.org/10.5281/zenodo.7988357) and an evaluation API (https://github.com/broadinstitute/MorphEm.git) to facilitate objective comparisons in future research and applications.

Li Xu, Siqi Wang, Kepeng Xu et al.

High-Dynamic-Range Wide-Color-Gamut (HDR-WCG) technology is becoming increasingly widespread, driving a growing need for converting Standard Dynamic Range (SDR) content to HDR. Existing methods primarily rely on fixed tone mapping operators, which struggle to handle the diverse appearances and degradations commonly present in real-world SDR content. To address this limitation, we propose a generalized SDR-to-HDR framework that enhances robustness by learning attribute-disentangled representations. Central to our approach is Realistic Attribute-Disentangled Representation Learning (RealRep), which explicitly disentangles luminance and chrominance components to capture intrinsic content variations across different SDR distributions. Furthermore, we design a Luma-/Chroma-aware negative exemplar generation strategy that constructs degradation-sensitive contrastive pairs, effectively modeling tone discrepancies across SDR styles. Building on these attribute-level priors, we introduce the Degradation-Domain Aware Controlled Mapping Network (DDACMNet), a lightweight, two-stage framework that performs adaptive hierarchical mapping guided by a control-aware normalization mechanism. DDACMNet dynamically modulates the mapping process via degradation-conditioned features, enabling robust adaptation across diverse degradation domains. Extensive experiments demonstrate that RealRep consistently outperforms state-of-the-art methods in both generalization and perceptually faithful HDR color gamut reconstruction.