Min Yao

Huiyuan Tian, Li Zhang, Shijian Li et al.

A longstanding challenge in Super-Resolution (SR) is how to efficiently enhance high-frequency details in Low-Resolution (LR) images while maintaining semantic coherence. This is particularly crucial in practical applications where SR models are often deployed on low-power devices. To address this issue, we propose an innovative asymmetric SR architecture featuring Multi-Depth Branch Module (MDBM). These MDBMs contain branches of different depths, designed to capture high- and low-frequency information simultaneously and efficiently. The hierarchical structure of MDBM allows the deeper branch to gradually accumulate fine-grained local details under the contextual guidance of the shallower branch. We visualize this process using feature maps, and further demonstrate the rationality and effectiveness of this design using proposed novel Fourier spectral analysis methods. Moreover, our model exhibits more significant spectral differentiation between branches than existing branch networks. This suggests that MDBM reduces feature redundancy and offers a more effective method for integrating high- and low-frequency information. Extensive qualitative and quantitative evaluations on various datasets show that our model can generate structurally consistent and visually realistic HR images. It achieves state-of-the-art (SOTA) results at a very fast inference speed. Our code is available at https://github.com/thy960112/MDBN.

Qian Shen, Fanghua Cao, Min Yao et al.

Large Language Models (LLMs) are widely applied in educational practices, such as for generating children's stories. However, the generated stories are often too difficult for children to read, and the operational cost of LLMs hinders their widespread adoption in educational settings. We used an existing expert-designed children's reading curriculum and its corresponding generated stories from GPT-4o and Llama 3.3 70B to design different experiments for fine-tuning three 8B-parameter LLMs, which then generated new English reading stories that were subjected to quantitative and qualitative evaluation. Our method prioritizes controllability over scale, enabling educators to target reading levels and error patterns with a compact, affordable model. Our evaluation results show that with appropriate fine-tuning designs, children's English reading stories generated by 8B LLMs perform better on difficulty-related metrics than those from zero-shot GPT-4o and Llama 3.3 70B, with almost no discernible safety issues. Such fine-tuned LLMs could be more broadly used by teachers, parents, and children in classrooms and at home to generate engaging English reading stories with children's interests, controllable difficulty and safety.

Jinsong Shao, Qineng Gong, Zeyu Yin et al.

The imperfect modeling of ternary complexes has limited the application of computer-aided drug discovery tools in PROTAC research and development. In this study, an AI-assisted approach for PROTAC molecule design pipeline named LM-PROTAC was developed, which stands for language model driven Proteolysis Targeting Chimera, by embedding a transformer-based generative model with dual constraints on structure and properties, referred to as the DCT. This study utilized the fragmentation representation of molecules and developed a language model driven pipeline. Firstly, a language model driven affinity model for protein compounds to screen molecular fragments with high affinity for the target protein. Secondly, structural and physicochemical properties of these fragments were constrained during the generation process to meet specific scenario requirements. Finally, a two-round screening of the preliminary generated molecules using a multidimensional property prediction model to generate a batch of PROTAC molecules capable of degrading disease-relevant target proteins for validation in vitro experiments, thus achieving a complete solution for AI-assisted PROTAC drug generation. Taking the tumor key target Wnt3a as an example, the LM-PROTAC pipeline successfully generated PROTAC molecules capable of inhibiting Wnt3a. The results show that DCT can efficiently generate PROTAC that targets and hydrolyses Wnt3a.