Siqi Zhang

Siqi Zhang, Yifan Hu, Liang Zhang et al. · eth-zurich

This paper takes an initial step to systematically investigate the generalization bounds of algorithms for solving nonconvex-(strongly)-concave (NC-SC/NC-C) stochastic minimax optimization measured by the stationarity of primal functions. We first establish algorithm-agnostic generalization bounds via uniform convergence between the empirical minimax problem and the population minimax problem. The sample complexities for achieving $ε$-generalization are $\tilde{\mathcal{O}}(dκ^2ε^{-2})$ and $\tilde{\mathcal{O}}(dε^{-4})$ for NC-SC and NC-C settings, respectively, where $d$ is the dimension and $κ$ is the condition number. We further study the algorithm-dependent generalization bounds via stability arguments of algorithms. In particular, we introduce a novel stability notion for minimax problems and build a connection between generalization bounds and the stability notion. As a result, we establish algorithm-dependent generalization bounds for stochastic gradient descent ascent (SGDA) algorithm and the more general sampling-determined algorithms.

Guangyu Wang, Jingkun Yue, Siqi Zhang et al.

A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation. We outline the data infrastructure, evaluation benchmarks, safety constraints and governance frameworks required. Biomedical world models may provide a foundation for simulation-guided, closed-loop and experimentally actionable biomedical discovery.

Lu Zhang, Siqi Zhang, Xu Yang et al.

Segmenting unseen objects is a crucial ability for the robot since it may encounter new environments during the operation. Recently, a popular solution is leveraging RGB-D features of large-scale synthetic data and directly applying the model to unseen real-world scenarios. However, the domain shift caused by the sim2real gap is inevitable, posing a crucial challenge to the segmentation model. In this paper, we emphasize the adaptation process across sim2real domains and model it as a learning problem on the BatchNorm parameters of a simulation-trained model. Specifically, we propose a novel non-parametric entropy objective, which formulates the learning objective for the test-time adaptation in an open-world manner. Then, a cross-modality knowledge distillation objective is further designed to encourage the test-time knowledge transfer for feature enhancement. Our approach can be efficiently implemented with only test images, without requiring annotations or revisiting the large-scale synthetic training data. Besides significant time savings, the proposed method consistently improves segmentation results on the overlap and boundary metrics, achieving state-of-the-art performance on unseen object instance segmentation.

Siqi Zhang, Lu Zhang, Zhiyong Liu et al.

Domain adaptive object detection (DAOD) aims to adapt the detector from a labelled source domain to an unlabelled target domain. In recent years, DAOD has attracted massive attention since it can alleviate performance degradation due to the large shift of data distributions in the wild. To align distributions between domains, adversarial learning is widely used in existing DAOD methods. However, the decision boundary for the adversarial domain discriminator may be inaccurate, causing the model biased towards the source domain. To alleviate this bias, we propose a novel Frequency-based Image Translation (FIT) framework for DAOD. First, by keeping domain-invariant frequency components and swapping domain-specific ones, we conduct image translation to reduce domain shift at the input level. Second, hierarchical adversarial feature learning is utilized to further mitigate the domain gap at the feature level. Finally, we design a joint loss to train the entire network in an end-to-end manner without extra training to obtain translated images. Extensive experiments on three challenging DAOD benchmarks demonstrate the effectiveness of our method.