Yu Zhang

Yu Zhang, Changhao Pan, Wenxiang Guo et al.

The scarcity of high-quality and multi-task singing datasets significantly hinders the development of diverse controllable and personalized singing tasks, as existing singing datasets suffer from low quality, limited diversity of languages and singers, absence of multi-technique information and realistic music scores, and poor task suitability. To tackle these problems, we present GTSinger, a large global, multi-technique, free-to-use, high-quality singing corpus with realistic music scores, designed for all singing tasks, along with its benchmarks. Particularly, (1) we collect 80.59 hours of high-quality singing voices, forming the largest recorded singing dataset; (2) 20 professional singers across nine widely spoken languages offer diverse timbres and styles; (3) we provide controlled comparison and phoneme-level annotations of six commonly used singing techniques, helping technique modeling and control; (4) GTSinger offers realistic music scores, assisting real-world musical composition; (5) singing voices are accompanied by manual phoneme-to-audio alignments, global style labels, and 16.16 hours of paired speech for various singing tasks. Moreover, to facilitate the use of GTSinger, we conduct four benchmark experiments: technique-controllable singing voice synthesis, technique recognition, style transfer, and speech-to-singing conversion. The demos can be found at http://aaronz345.github.io/GTSingerDemo/. We provide the dataset and the code for processing data and conducting benchmarks at https://huggingface.co/datasets/AaronZ345/GTSinger and https://github.com/AaronZ345/GTSinger.

Yulong Zhang, Shuhao Chen, Weisen Jiang et al.

Limited transferability hinders the performance of deep learning models when applied to new application scenarios. Recently, Unsupervised Domain Adaptation (UDA) has achieved significant progress in addressing this issue via learning domain-invariant features. However, the performance of existing UDA methods is constrained by the large domain shift and limited target domain data. To alleviate these issues, we propose DomAin-guided Conditional Diffusion Model (DACDM) to generate high-fidelity and diversity samples for the target domain. In the proposed DACDM, by introducing class information, the labels of generated samples can be controlled, and a domain classifier is further introduced in DACDM to guide the generated samples for the target domain. The generated samples help existing UDA methods transfer from the source domain to the target domain more easily, thus improving the transfer performance. Extensive experiments on various benchmarks demonstrate that DACDM brings a large improvement to the performance of existing UDA methods.

Shuai Fu, Xiequn Wang, Qiushi Huang et al.

With the prevalence of large-scale pretrained vision-language models (VLMs), such as CLIP, soft-prompt tuning has become a popular method for adapting these models to various downstream tasks. However, few works delve into the inherent properties of learnable soft-prompt vectors, specifically the impact of their norms to the performance of VLMs. This motivates us to pose an unexplored research question: ``Do we need to normalize the soft prompts in VLMs?'' To fill this research gap, we first uncover a phenomenon, called the \textbf{Low-Norm Effect} by performing extensive corruption experiments, suggesting that reducing the norms of certain learned prompts occasionally enhances the performance of VLMs, while increasing them often degrades it. To harness this effect, we propose a novel method named \textbf{N}ormalizing th\textbf{e} soft-pro\textbf{m}pt v\textbf{e}ctors of vi\textbf{si}on-language model\textbf{s} (\textbf{Nemesis}) to normalize soft-prompt vectors in VLMs. To the best of our knowledge, our work is the first to systematically investigate the role of norms of soft-prompt vector in VLMs, offering valuable insights for future research in soft-prompt tuning. The code is available at \texttt{\href{https://github.com/ShyFoo/Nemesis}{https://github.com/ShyFoo/Nemesis}}.

Feng Xu, Chuang Zhu, Wenqi Tang et al.

Objectives: To develop and validate a deep learning (DL)-based primary tumor biopsy signature for predicting axillary lymph node (ALN) metastasis preoperatively in early breast cancer (EBC) patients with clinically negative ALN. Methods: A total of 1,058 EBC patients with pathologically confirmed ALN status were enrolled from May 2010 to August 2020. A DL core-needle biopsy (DL-CNB) model was built on the attention-based multiple instance-learning (AMIL) framework to predict ALN status utilizing the DL features, which were extracted from the cancer areas of digitized whole-slide images (WSIs) of breast CNB specimens annotated by two pathologists. Accuracy, sensitivity, specificity, receiver operating characteristic (ROC) curves, and areas under the ROC curve (AUCs) were analyzed to evaluate our model. Results: The best-performing DL-CNB model with VGG16_BN as the feature extractor achieved an AUC of 0.816 (95% confidence interval (CI): 0.758, 0.865) in predicting positive ALN metastasis in the independent test cohort. Furthermore, our model incorporating the clinical data, which was called DL-CNB+C, yielded the best accuracy of 0.831 (95%CI: 0.775, 0.878), especially for patients younger than 50 years (AUC: 0.918, 95%CI: 0.825, 0.971). The interpretation of DL-CNB model showed that the top signatures most predictive of ALN metastasis were characterized by the nucleus features including density ($p$ = 0.015), circumference ($p$ = 0.009), circularity ($p$ = 0.010), and orientation ($p$ = 0.012). Conclusion: Our study provides a novel DL-based biomarker on primary tumor CNB slides to predict the metastatic status of ALN preoperatively for patients with EBC. The codes and dataset are available at https://github.com/bupt-ai-cz/BALNMP

Yu Zhang, Jialei Zhou, Xinchen Li et al.

Current text-to-image diffusion generation typically employs complete-text conditioning. Due to the intricate syntax, diffusion transformers (DiTs) inherently suffer from a comprehension defect of complete-text captions. One-fly complete-text input either overlooks critical semantic details or causes semantic confusion by simultaneously modeling diverse semantic primitive types. To mitigate this defect of DiTs, we propose a novel split-text conditioning framework named DiT-ST. This framework converts a complete-text caption into a split-text caption, a collection of simplified sentences, to explicitly express various semantic primitives and their interconnections. The split-text caption is then injected into different denoising stages of DiT-ST in a hierarchical and incremental manner. Specifically, DiT-ST leverages Large Language Models to parse captions, extracting diverse primitives and hierarchically sorting out and constructing these primitives into a split-text input. Moreover, we partition the diffusion denoising process according to its differential sensitivities to diverse semantic primitive types and determine the appropriate timesteps to incrementally inject tokens of diverse semantic primitive types into input tokens via cross-attention. In this way, DiT-ST enhances the representation learning of specific semantic primitive types across different stages. Extensive experiments validate the effectiveness of our proposed DiT-ST in mitigating the complete-text comprehension defect.

Jinjing Zhu, Feiyang Ye, Qiao Xiao et al.

Despite the progress made in domain adaptation, solving Unsupervised Domain Adaptation (UDA) problems with a general method under complex conditions caused by label shifts between domains remains a formidable task. In this work, we comprehensively investigate four distinct UDA settings including closed set domain adaptation, partial domain adaptation, open set domain adaptation, and universal domain adaptation, where shared common classes between source and target domains coexist alongside domain-specific private classes. The prominent challenges inherent in diverse UDA settings center around the discrimination of common/private classes and the precise measurement of domain discrepancy. To surmount these challenges effectively, we propose a novel yet effective method called Learning Instance Weighting for Unsupervised Domain Adaptation (LIWUDA), which caters to various UDA settings. Specifically, the proposed LIWUDA method constructs a weight network to assign weights to each instance based on its probability of belonging to common classes, and designs Weighted Optimal Transport (WOT) for domain alignment by leveraging instance weights. Additionally, the proposed LIWUDA method devises a Separate and Align (SA) loss to separate instances with low similarities and align instances with high similarities. To guide the learning of the weight network, Intra-domain Optimal Transport (IOT) is proposed to enforce the weights of instances in common classes to follow a uniform distribution. Through the integration of those three components, the proposed LIWUDA method demonstrates its capability to address all four UDA settings in a unified manner. Experimental evaluations conducted on three benchmark datasets substantiate the effectiveness of the proposed LIWUDA method.

Yu Zhang, Qi Zhang, Zixuan Gong et al.

Contrastive Language-Image Pretraining (CLIP) has achieved remarkable success, leading to rapid advancements in multimodal studies. However, CLIP faces a notable challenge in terms of inefficient data utilization. It relies on a single contrastive supervision for each image-text pair during representation learning, disregarding a substantial amount of valuable information that could offer richer supervision. Additionally, the retention of non-informative tokens leads to increased computational demands and time costs, particularly in CLIP's ViT image encoder. To address these issues, we propose Multi-Perspective Language-Image Pretraining (MLIP). In MLIP, we leverage the frequency transform's sensitivity to both high and low-frequency variations, which complements the spatial domain's sensitivity limited to low-frequency variations only. By incorporating frequency transforms and token-level alignment, we expand CILP's single supervision into multi-domain and multi-level supervision, enabling a more thorough exploration of informative image features. Additionally, we introduce a token merging method guided by comprehensive semantics from the frequency and spatial domains. This allows us to merge tokens to multi-granularity tokens with a controllable compression rate to accelerate CLIP. Extensive experiments validate the effectiveness of our design.

Zhenyuan Ning, Ke Wang, Shengzhou Zhong et al.

Breast ultrasound (BUS) image segmentation plays a crucial role in a computer-aided diagnosis system, which is regarded as a useful tool to help increase the accuracy of breast cancer diagnosis. Recently, many deep learning methods have been developed for segmentation of BUS image and show some advantages compared with conventional region-, model-, and traditional learning-based methods. However, previous deep learning methods typically use skip-connection to concatenate the encoder and decoder, which might not make full fusion of coarse-to-fine features from encoder and decoder. Since the structure and edge of lesion in BUS image are common blurred, these would make it difficult to learn the discriminant information of structure and edge, and reduce the performance. To this end, we propose and evaluate a coarse-to-fine fusion convolutional network (CF2-Net) based on a novel feature integration strategy (forming an 'E'-like type) for BUS image segmentation. To enhance contour and provide structural information, we concatenate a super-pixel image and the original image as the input of CF2-Net. Meanwhile, to highlight the differences in the lesion regions with variable sizes and relieve the imbalance issue, we further design a weighted-balanced loss function to train the CF2-Net effectively. The proposed CF2-Net was evaluated on an open dataset by using four-fold cross validation. The results of the experiment demonstrate that the CF2-Net obtains state-of-the-art performance when compared with other deep learning-based methods

Yu Zhang, Gongbo Liang, Nathan Jacobs et al.

Generalization is one of the key challenges in the clinical validation and application of deep learning models to medical images. Studies have shown that such models trained on publicly available datasets often do not work well on real-world clinical data due to the differences in patient population and image device configurations. Also, manually annotating clinical images is expensive. In this work, we propose an unsupervised domain adaptation (UDA) method using Cycle-GAN to improve the generalization ability of the model without using any additional manual annotations.

Gongbo Liang, Xiaoqin Wang, Yu Zhang et al.

Breast cancer is the malignant tumor that causes the highest number of cancer deaths in females. Digital mammograms (DM or 2D mammogram) and digital breast tomosynthesis (DBT or 3D mammogram) are the two types of mammography imagery that are used in clinical practice for breast cancer detection and diagnosis. Radiologists usually read both imaging modalities in combination; however, existing computer-aided diagnosis tools are designed using only one imaging modality. Inspired by clinical practice, we propose an innovative convolutional neural network (CNN) architecture for breast cancer classification, which uses both 2D and 3D mammograms, simultaneously. Our experiment shows that the proposed method significantly improves the performance of breast cancer classification. By assembling three CNN classifiers, the proposed model achieves 0.97 AUC, which is 34.72% higher than the methods using only one imaging modality.

Yu Zhang, Xiaoqin Wang, Hunter Blanton et al.

Automated methods for breast cancer detection have focused on 2D mammography and have largely ignored 3D digital breast tomosynthesis (DBT), which is frequently used in clinical practice. The two key challenges in developing automated methods for DBT classification are handling the variable number of slices and retaining slice-to-slice changes. We propose a novel deep 2D convolutional neural network (CNN) architecture for DBT classification that simultaneously overcomes both challenges. Our approach operates on the full volume, regardless of the number of slices, and allows the use of pre-trained 2D CNNs for feature extraction, which is important given the limited amount of annotated training data. In an extensive evaluation on a real-world clinical dataset, our approach achieves 0.854 auROC, which is 28.80% higher than approaches based on 3D CNNs. We also find that these improvements are stable across a range of model configurations.

Andrew Rosenberg, Yu Zhang, Bhuvana Ramabhadran et al.

Recent success of the Tacotron speech synthesis architecture and its variants in producing natural sounding multi-speaker synthesized speech has raised the exciting possibility of replacing expensive, manually transcribed, domain-specific, human speech that is used to train speech recognizers. The multi-speaker speech synthesis architecture can learn latent embedding spaces of prosody, speaker and style variations derived from input acoustic representations thereby allowing for manipulation of the synthesized speech. In this paper, we evaluate the feasibility of enhancing speech recognition performance using speech synthesis using two corpora from different domains. We explore algorithms to provide the necessary acoustic and lexical diversity needed for robust speech recognition. Finally, we demonstrate the feasibility of this approach as a data augmentation strategy for domain-transfer. We find that improvements to speech recognition performance is achievable by augmenting training data with synthesized material. However, there remains a substantial gap in performance between recognizers trained on human speech those trained on synthesized speech.

Qi Zhu, Xiang Ren, Jingbo Shang et al.

Extracting entities and their relations from text is an important task for understanding massive text corpora. Open information extraction (IE) systems mine relation tuples (i.e., entity arguments and a predicate string to describe their relation) from sentences. These relation tuples are not confined to a predefined schema for the relations of interests. However, current Open IE systems focus on modeling local context information in a sentence to extract relation tuples, while ignoring the fact that global statistics in a large corpus can be collectively leveraged to identify high-quality sentence-level extractions. In this paper, we propose a novel Open IE system, called ReMine, which integrates local context signals and global structural signals in a unified, distant-supervision framework. Leveraging facts from external knowledge bases as supervision, the new system can be applied to many different domains to facilitate sentence-level tuple extractions using corpus-level statistics. Our system operates by solving a joint optimization problem to unify (1) segmenting entity/relation phrases in individual sentences based on local context; and (2) measuring the quality of tuples extracted from individual sentences with a translating-based objective. Learning the two subtasks jointly helps correct errors produced in each subtask so that they can mutually enhance each other. Experiments on two real-world corpora from different domains demonstrate the effectiveness, generality, and robustness of ReMine when compared to state-of-the-art open IE systems.