Xu Zhang

Wenliang Li, Rui Yan, Xu Zhang et al.

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt engineering and multi-agent approaches typically optimize isolated inferences, neglecting the accumulation of reusable clinical experience. To address this, this study proposes a novel Multi-Agent Clinical Diagnosis (MACD) framework, which allows LLMs to self-learn clinical knowledge via a multi-agent pipeline that summarizes, refines, and applies diagnostic insights. It mirrors how physicians develop expertise through experience, enabling more focused and accurate diagnosis on key disease-specific cues. We further extend it to a MACD-human collaborative workflow, where multiple LLM-based diagnostician agents engage in iterative consultations, supported by an evaluator agent and human oversight for cases where agreement is not reached. Evaluated on 4,390 real-world patient cases across seven diseases using diverse open-source LLMs (Llama-3.1 8B/70B, DeepSeek-R1-Distill-Llama 70B), MACD significantly improves primary diagnostic accuracy, outperforming established clinical guidelines with gains up to 22.3% (MACD). In direct comparison with physician-only diagnosis under the same evaluation protocol, MACD achieves comparable or superior performance, with improvements up to 16%. Furthermore, the MACD-human workflow yields an 18.6% improvement over physician-only diagnosis, demonstrating the synergistic potential of human-AI collaboration. Notably, the self-learned clinical knowledge exhibits strong cross-model stability, transferability across LLMs, and capacity for model-specific personalization.This work thus presents a scalable self-learning paradigm that bridges the gap between the intrinsic knowledge of LLMs.

Baizhi Wang, Rui Yan, Wenxin Ma et al.

Histomorphology is crucial in breast cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key and fine-grained pathological features. To address this limitation, we propose a novel framework that explicitly incorporates histomorphology (tumor cellularity, cellular morphology, and tissue architecture) into WSI classification. Specifically, our approach consists of three key components: (1) estimating the importance of tumor-related histomorphology information at the patch level based on medical prior knowledge; (2) generating representative cluster-level features through histomorphology-driven cluster pooling; and (3) enabling WSI-level classification through histomorphology-driven multi-instance aggregation. With the incorporation of histomorphological information, our framework strengthens the model's ability to capture key and fine-grained pathological patterns, thereby enhancing WSI classification performance. Experimental results demonstrate its effectiveness, achieving high diagnostic accuracy for molecular subtyping and cancer subtyping. The code will be made available at https://github.com/Badgewho/HMDMIL.

Mingke Xiao, Yue Su, Liang Yu et al.

The deployment of neural networks in vehicle platforms and wearable Artificial Intelligence-of-Things (AIOT) scenarios has become a research area that has attracted much attention. With the continuous evolution of deep learning technology, many image classification models are committed to improving recognition accuracy, but this is often accompanied by problems such as large model resource usage, complex structure, and high power consumption, which makes it challenging to deploy on resource-constrained platforms. Herein, we propose an ultra-lightweight binary neural network (BNN) model designed for hardware deployment, and conduct image classification research based on the German Traffic Sign Recognition Benchmark (GTSRB) dataset. In addition, we also verify it on the Chinese Traffic Sign (CTS) and Belgian Traffic Sign (BTS) datasets. The proposed model shows excellent recognition performance with an accuracy of up to 97.64%, making it one of the best performing BNN models in the GTSRB dataset. Compared with the full-precision model, the accuracy loss is controlled within 1%, and the parameter storage overhead of the model is only 10% of that of the full-precision model. More importantly, our network model only relies on logical operations and low-bit width fixed-point addition and subtraction operations during the inference phase, which greatly simplifies the design complexity of the processing element (PE). Our research shows the great potential of BNN in the hardware deployment of computer vision models, especially in the field of computer vision tasks related to autonomous driving.