Yuan Luo

Shaocong Long, Qianyu Zhou, Chenhao Ying et al.

Domain generalization(DG) endeavors to develop robust models that possess strong generalizability while preserving excellent discriminability. Nonetheless, pivotal DG techniques tend to improve the feature generalizability by learning domain-invariant representations, inadvertently overlooking the feature discriminability. On the one hand, the simultaneous attainment of generalizability and discriminability of features presents a complex challenge, often entailing inherent contradictions. This challenge becomes particularly pronounced when domain-invariant features manifest reduced discriminability owing to the inclusion of unstable factors, i.e., spurious correlations. On the other hand, prevailing domain-invariant methods can be categorized as category-level alignment, susceptible to discarding indispensable features possessing substantial generalizability and narrowing intra-class variations. To surmount these obstacles, we rethink DG from a new perspective that concurrently imbues features with formidable discriminability and robust generalizability, and present a novel framework, namely, Discriminative Microscopic Distribution Alignment~(DMDA). DMDA incorporates two core components: Selective Channel Pruning~(SCP) and Micro-level Distribution Alignment~(MDA). Concretely, SCP attempts to curtail redundancy within neural networks, prioritizing stable attributes conducive to accurate classification. This approach alleviates the adverse effect of spurious domain invariance and amplifies the feature discriminability. Besides, MDA accentuates micro-level alignment within each class, going beyond mere category-level alignment. Extensive experiments on four benchmark datasets corroborate that DMDA achieves comparable results to state-of-the-art methods in DG, underscoring the efficacy of our method.

Betina Idnay, Zihan Xu, William G. Adams et al.

This study reports a comprehensive environmental scan of the generative AI (GenAI) infrastructure in the national network for clinical and translational science across 36 institutions supported by the Clinical and Translational Science Award (CTSA) Program led by the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) at the United States. With the rapid advancement of GenAI technologies, including large language models (LLMs), healthcare institutions face unprecedented opportunities and challenges. This research explores the current status of GenAI integration, focusing on stakeholder roles, governance structures, and ethical considerations by administering a survey among leaders of health institutions (i.e., representing academic medical centers and health systems) to assess the institutional readiness and approach towards GenAI adoption. Key findings indicate a diverse range of institutional strategies, with most organizations in the experimental phase of GenAI deployment. The study highlights significant variations in governance models, with a strong preference for centralized decision-making but notable gaps in workforce training and ethical oversight. Moreover, the results underscore the need for a more coordinated approach to GenAI governance, emphasizing collaboration among senior leaders, clinicians, information technology staff, and researchers. Our analysis also reveals concerns regarding GenAI bias, data security, and stakeholder trust, which must be addressed to ensure the ethical and effective implementation of GenAI technologies. This study offers valuable insights into the challenges and opportunities of GenAI integration in healthcare, providing a roadmap for institutions aiming to leverage GenAI for improved quality of care and operational efficiency.

Shaocong Long, Qianyu Zhou, Xikun Jiang et al.

Domain generalization (DG) strives to address distribution shifts across diverse environments to enhance model's generalizability. Current DG approaches are confined to acquiring robust representations with continuous features, specifically training at the pixel level. However, this DG paradigm may struggle to mitigate distribution gaps in dealing with a large space of continuous features, rendering it susceptible to pixel details that exhibit spurious correlations or noise. In this paper, we first theoretically demonstrate that the domain gaps in continuous representation learning can be reduced by the discretization process. Based on this inspiring finding, we introduce a novel learning paradigm for DG, termed Discrete Domain Generalization (DDG). DDG proposes to use a codebook to quantize the feature map into discrete codewords, aligning semantic-equivalent information in a shared discrete representation space that prioritizes semantic-level information over pixel-level intricacies. By learning at the semantic level, DDG diminishes the number of latent features, optimizing the utilization of the representation space and alleviating the risks associated with the wide-ranging space of continuous features. Extensive experiments across widely employed benchmarks in DG demonstrate DDG's superior performance compared to state-of-the-art approaches, underscoring its potential to reduce the distribution gaps and enhance the model's generalizability.

Lu Chen, Han Yang, Hu Wang et al.

Adversarial examples have attracted significant attention over the years, yet understanding their frequency-based characteristics remains insufficient. In this paper, we investigate the intriguing properties of adversarial examples in the frequency domain for the image classification task, with the following key findings. (1) As the high-frequency components increase, the performance gap between adversarial and natural examples becomes increasingly pronounced. (2) The model performance against filtered adversarial examples initially increases to a peak and declines to its inherent robustness. (3) In Convolutional Neural Networks, mid- and high-frequency components of adversarial examples exhibit their attack capabilities, while in Transformers, low- and mid-frequency components of adversarial examples are particularly effective. These results suggest that different network architectures have different frequency preferences and that differences in frequency components between adversarial and natural examples may directly influence model robustness. Based on our findings, we further conclude with three useful proposals that serve as a valuable reference to the AI model security community.

Bradley J. Nelson, Yuan Luo

Dimensionality reduction techniques are powerful tools for data preprocessing and visualization which typically come with few guarantees concerning the topological correctness of an embedding. The interleaving distance between the persistent homology of Vietoris-Rips filtrations can be used to identify a scale at which topological features such as clusters or holes in an embedding and original data set are in correspondence. We show how optimization seeking to minimize the interleaving distance can be incorporated into dimensionality reduction algorithms, and explicitly demonstrate its use in finding an optimal linear projection. We demonstrate the utility of this framework to data visualization.